Published on in Vol 9 (2023)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/49968, first published .
Nasopharyngeal Cancer Incidence and Mortality in 185 Countries in 2020 and the Projected Burden in 2040: Population-Based Global Epidemiological Profiling

Nasopharyngeal Cancer Incidence and Mortality in 185 Countries in 2020 and the Projected Burden in 2040: Population-Based Global Epidemiological Profiling

Nasopharyngeal Cancer Incidence and Mortality in 185 Countries in 2020 and the Projected Burden in 2040: Population-Based Global Epidemiological Profiling

Journals

  1. Li H, Liang B, Gao X, Peng Y, Liu Q, Qiu L, Lin J. Cathepsin B-Activated PET Tracer for In Vivo Tumor Imaging. Molecular Pharmaceutics 2024;21(3):1382 View
  2. Wang R, Ke R, Yu Y, Lu G, Wu S. Addition of nimotuzumab to concurrent chemoradiotherapy after induction chemotherapy improves outcomes of patients with locally advanced nasopharyngeal carcinoma. Frontiers in Pharmacology 2024;15 View
  3. Makowska A, Weiskirchen R. Nasopharyngeal Carcinoma Cell Lines: Reliable Alternatives to Primary Nasopharyngeal Cells?. Cells 2024;13(7):559 View
  4. Chen Z, Ling J, Zhang S, Feng Y, Xie Y, Liu X, Hou T. Predicting the overall survival and progression‐free survival of nasopharyngeal carcinoma patients based on hemoglobin, albumin, and globulin ratio and classical clinicopathological parameters. Head & Neck 2024;46(10):2600 View
  5. Shen H, Zhang C, Li S, Liang Y, Lee L, Aggarwal N, Wun K, Liu J, Nadarajan S, Weng C, Ling H, Tay J, Wang D, Yao S, Hwang I, Lee Y, Chang M. Prodrug-conjugated tumor-seeking commensals for targeted cancer therapy. Nature Communications 2024;15(1) View
  6. Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O’Leary B, Braña I, Harrington K. A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies. Cancer Treatment Reviews 2024;128:102772 View
  7. Xiao M, Tu L, Zhou T, He Y, Li X, Zuo Q. Predictive model based on multiple immunofluorescence quantitative analysis for pathological complete response to neoadjuvant immunochemotherapy in lung squamous cell carcinoma. Frontiers in Oncology 2024;14 View
  8. Fatima K, Andleeb A, Nasreen S, Sofi M, Wani U, Rasool M, Najmi A, Qamar S, Ahmad N, Ryhan R. Induction versus Adjuvant Chemotherapy Combined with Concurrent Chemoradiation: What Is Beneficial in Locally Advanced Nasopharyngeal Carcinoma—A 5-Year Comparative Study at a Tertiary Care Center in North India. South Asian Journal of Cancer 2024 View
  9. Yu Y, Lu G, Wang R, Song Y, Wu S. Additional PD-1 inhibitor improves complete response to induction chemotherapy in locally advanced nasopharyngeal carcinoma. Frontiers in Immunology 2024;15 View
  10. Lei S, Chen L, Ji P, Li K, Li Q, Huang C, Wang G, Ma J, Guo R, Tang L. Global burdens of nasopharyngeal carcinoma in children and young adults and predictions to 2040. Oral Oncology 2024;155:106891 View
  11. Sun B, Yuan Z, Wang M, Xu L, Feng J, Chen J. The chemokine CCL14 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma. Discover Oncology 2024;15(1) View
  12. Guo L, Rao M, Yu Y, Lin Q, Wu S. The addition of nimotuzumab during concurrent chemoradiotherapy improved survival outcomes in locally advanced nasopharyngeal carcinoma patients with optimal response to induction chemotherapy. BMC Cancer 2024;24(1) View
  13. Lim E, Ong Y, Chou Y, Then C. Interconnected influences of tumour and host microbiota on treatment response and side effects in nasopharyngeal cancer. Critical Reviews in Oncology/Hematology 2024;202:104468 View
  14. Zeng F, Zhang D, Chen S, Chen R, Chen C, Huang S, Li D, Zhang X, Chen J, Mo C, Gao L, Zeng J, Xiong J, Chen Z, Bai F. Application of fecal immunochemical test in colorectal cancer screening: A community-based, cross-sectional study in average-risk individuals in Hainan. World Journal of Gastrointestinal Oncology 2024;16(8):3445 View
  15. Ashique S, Houshyari M, Islam A, Pal R, Ghazanfar S, Taghizadeh-Hesary F. The role of microbiota in nasopharyngeal cancer: Where do we stand?. Oral Oncology 2024;158:106982 View
  16. Hu L, Huang Y, Zhang J. Maintenance treatment with oral anticancer agents after first-line chemotherapy in patients with recurrent or metastatic nasopharyngeal carcinoma: a systematic review and meta-analysis. European Archives of Oto-Rhino-Laryngology 2025;282(2):589 View
  17. Ho-Fun Lee V. Approaching a cure for nasopharyngeal carcinoma: how close are we from there?. The Lancet Regional Health - Western Pacific 2024;50:101186 View
  18. Zhu Y, Xue F. Comparing long-term efficacy and safety of GP versus TPF sequential chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: a propensity score-matched analysis. BMC Cancer 2024;24(1) View
  19. Ko M, Yang K, Ahn Y, Ju S, Oh D, Kim Y, Kwon D, Park S, Lee K. Dosimetric Comparison and Selection Criteria of Intensity-Modulated Proton Therapy and Intensity-Modulated Radiation Therapy for Adaptive Re-Plan in T3-4 Nasopharynx Cancer Patients. Cancers 2024;16(19):3402 View
  20. Yi Y, Zhou B, Man T, Xu Z, Tang H, Li J, Sun Z. Resveratrol Inhibits Nasopharyngeal Carcinoma (NPC) by Targeting the MAPK Signaling Pathway. Anti-Cancer Agents in Medicinal Chemistry 2024;24(16):1207 View
  21. Chen X, Li S, Sun B. Downregulation of short‐stature homeobox protein 2 suppresses gastric cancer cell growth and stemness in vitro and in vivo via inactivating wnt/β‐catenin signaling. Drug Development Research 2024;85(7) View
  22. Krishnan M, Basappa S, Vinaya Kumar M, Sekar G. Immune checkpoint inhibition in NPC: A comprehensive review of PD-L1 overexpression and treatment responses. Oral Oncology Reports 2024;12:100680 View
  23. Guo L, Dai Y, Yu Y, Wu S. Gender-Specific Survival of Nasopharyngeal Carcinoma in Endemic and Non-Endemic Areas Based on the US SEER Database and a Chinese Single-Institutional Registry. Clinical Epidemiology 2024;Volume 16:769 View
  24. Qiu S, Chen A, Li Q, Guo L, Cai J, Xue X. Clinical Study of Tuhuanglian Liquid Wet Compress on Acute Radiation Dermatitis of Nasopharyngeal Carcinoma. Critical Reviews in Biomedical Engineering 2025;53(1):23 View
  25. Guo L, Hong J, Wang R, Chen G, Wu S. Nasopharyngeal carcinoma survival by histology in endemic and non-endemic areas. Annals of Medicine 2024;56(1) View
  26. Jiménez-Labaig P, Aymerich C, Rullan A, Cacicedo J, Braña I, Nutting C, Newbold K, Harrington K, Catalan A. Prevalence of depressive and anxiety symptoms in patients with head and neck cancer undergoing radiotherapy: A systematic review and meta-analysis of longitudinal studies. Radiotherapy and Oncology 2025;202:110649 View
  27. Aydin A, Yuceer R, Yildirim S, Unlu A, Kayikcioglu E, Kocer M. The Prognostic Significance of CD47, CD68, and CD163 Expression Levels and Their Relationship with MLR and MAR in Locally Advanced and Oligometastatic Nasopharyngeal Carcinoma. Diagnostics 2024;14(23):2648 View
  28. Wu T, Miao W, Qukuerhan A, Alimu N, Feng J, Wang C, Zhang H, Du H, Chen L. Global, Regional, and National Burden of Nasopharyngeal Carcinoma from 1990 to 2021. The Laryngoscope 2025;135(4):1409 View
  29. Lu Z, Ye Z, Li P, Jiang Y, Han S, Ma L. An MSRE-Assisted Glycerol-Enhanced RPA-CRISPR/Cas12a Method for Methylation Detection. Biosensors 2024;14(12):608 View
  30. Tseng H, Shen C, Kao P, Chuang C, Yan D, Liao Y, Lu X, Sheu T, Shen W. Prediction of Persistent Tumor Status in Nasopharyngeal Carcinoma Post-Radiotherapy-Related Treatment: A Machine Learning Approach. Cancers 2024;17(1):96 View
  31. Spreafico A, Winquist E, Ho C, O’Sullivan B, Bouganim N, Chua N, Doucette S, Siu L, Hao D. A Canadian Perspective on Systemic Therapy for Recurrent or Metastatic Nasopharyngeal Carcinoma. Current Oncology 2025;32(1):48 View
  32. Cui M, Cheng H, Yuan L, Zhang M, Chen J, Jia J, Li P, Luo L. Burden of nasopharyngeal carcinoma in Asia from 1990 to 2021. Journal of Dentistry 2025;154:105583 View
  33. Zahu R, Urian D, Manolescu V, Ungureanu A, Bodale C, Iacob A, Vesa S, Tiple C, Kacso G. Clinical Outcomes for Nasopharyngeal Cancer in Non-Asian Patients: A Single-Center Experience. Journal of Clinical Medicine 2025;14(4):1177 View
  34. Filippini D, Broseghini E, Liberale C, Gallerani G, Siepe G, Nobili E, Ferracin M, Molteni G. Vaccine-Based Immunotherapy for Oropharyngeal and Nasopharyngeal Cancers. Journal of Clinical Medicine 2025;14(4):1170 View
  35. Li H, Liu Y, Yuan H, Cai P, Wu T, Yang Z, Nie J, Zhang W, Huang Z, Liu N, Chen Y, Zhou Z. Development and Evaluation of Novel 68Ga/177Lu-Labeled PSMA Inhibitors with Enhanced Pharmacokinetics and Tumor Imaging for Prostate Cancer. Molecular Pharmaceutics 2025;22(3):1584 View
  36. Colevas A, Talebi Z, Winters E, Even C, Lee V, Gillison M, Khan S, Lu R, Pinsky B, Soldan S, Vladmirova O, Lieberman P, Messick T. First-in-Human Clinical Trial of a Small-Molecule EBNA1 Inhibitor, VK-2019, in Patients with Epstein-Barr–Positive Nasopharyngeal Cancer, with Pharmacokinetic and Pharmacodynamic Studies. Clinical Cancer Research 2025;31(5):815 View
  37. Yu Y, Dai Y, Zhang Z, Lu G, Lin Q, Wu S. Induction Camrelizumab and Modified TPF (Nab‐Paclitaxel, Cisplatin, and S‐1) in Locoregionally Advanced Nasopharyngeal Carcinoma. Cancer Science 2025;116(6):1616 View
  38. Cochin T, Saâda-Bouzid E. Toripalimab en association avec cisplatine et gemcitabine pour le traitement des carcinomes indifférenciés du nasopharynx récidivants ou métastatique (UCNT RM) en première ligne. Bulletin du Cancer 2025;112(6):557 View
  39. Sandra F, Rahayu W, Anthony I, Lokantari M, Annisa S, Chouw A, Celinna M, Lee K. Histone Potentiates Inositol Hexakisphosphate in Inducing Apoptosis of HONE-1 Nasopharyngeal Cancer Cells. Brazilian Archives of Biology and Technology 2025;68 View
  40. Neo J, Ong E, Zhang X, Chow W, Wee J, Fong K, Soong Y, Tan T, Liu J, Loh K, Tay J, Ang M, Tan S, Lim D, Chua M. Plasma Epstein-Barr virus DNA for disease surveillance in endemic nasopharyngeal carcinoma: Analysis of a real-world database. European Journal of Cancer 2025;220:115396 View
  41. Feng M, Gong W, Zhu X, Zhu J, Hu J, Xu W, Ma Z, Fu S, Chen X. Covalent binding of 5-tetradecyloxy-2-furoic acid (TOFA) and c(RGDfK) and its co-delivery with Lipusu, a novel synergistic strategy to inhibit the proliferation of nasopharyngeal cancer. European Journal of Pharmaceutical Sciences 2025;209:107092 View
  42. Wang Q, Yin X, Liu H, Wang Q, Zhang L, Wang Y, Lu H. Mitochondrial function changes in T cell subsets during radiotherapy for patients with nasopharyngeal carcinoma. Oncology Letters 2025;29(6):1 View
  43. Li K, Kwok H, Pan N, Cheng L, Ma K. Pre-treatment and post-treatment nasopharyngeal carcinoma imaging: imaging updates, pearls and pitfalls. Neuroradiology 2025;67(4):1023 View
  44. Hsia B, Sure A, Dongre R, Jo N, Kuzniar J, Bitar G, Alshaka S, Kim J, Valencia-Sanchez B, Brandel M, Sato M, Crawford J, Levy M, Polster S, Patel V. Molecular Profiling of Nasopharyngeal Carcinoma Using the AACR Project GENIE Repository. Cancers 2025;17(9):1544 View
  45. Huang K, Lin X, Hu J, Xia T, Xu F, Huang J, Zhou N. Epstein-Barr virus mRNA vaccine synergizes with NK cells to enhance nasopharyngeal carcinoma eradication in humanized mice. Molecular Therapy Oncology 2025;33(2):200986 View
  46. Tao J, Shing J, Yu K, Kreimer A, Hsieh M, Pawlish K, Li J, Qiao B, Rees J, Taparra K, Vo J, Engels E. Spectrum of cancer risk in Asian American and Pacific Islander solid organ transplant recipients. JNCI: Journal of the National Cancer Institute 2025;117(7):1456 View
  47. Bu X, Liu Z, Liu J, Lei M. Global tobacco-related head and neck cancer burden from 1990 to 2019: estimates from the global burden of disease study 2019. Environmental Sciences Europe 2025;37(1) View
  48. Makowska A, Buhl E, Göschel M, Kuo C, Nothbaum C, Toktamis E, Shen L, Abdallah A, Weiskirchen R, Kontny U. Characterization and comparison of two NPC cell lines, C17 and C666-1, as models for studying the pathogenesis of nasopharyngeal carcinoma. Biochemical and Biophysical Research Communications 2025;772:152053 View
  49. Li W, Liang L, Liu S, Zeng F, Cao J, Lei Y, Yuan X, He Q, Zhou Y. CD38 inhibits ferroptosis to promote radiotherapy resistance in nasopharyngeal carcinoma by competitively binding to TRIM21 to stabilize SLC7A11 protein. International Journal of Biological Macromolecules 2025;317:144742 View
  50. Li J, Hou H, Song J, Yuan X, Ma M, Yang K, Wang P, Guan Y, Kuang D, Sun Z, Meng F, Peng J, Cheng L. Development of a Diagnostic Algorithm for Epstein‐Barr Virus‐Related Diseases: A Retrospective Observational Study. Journal of Medical Virology 2025;97(6) View
  51. Jang W, Kim S, Son Y, Kim S, Lee S, Kim H, Jo H, Park J, Lee K, Lee H, Rahmati M, Woo S, Hwang J, Kang J, Smith L, Yon D. Global, Regional, and National Burden of Pharyngeal Cancer and Projections to 2050 in 185 Countries: A Population-Based Systematic Analysis of GLOBOCAN 2022. Journal of Korean Medical Science 2025;40(30) View
  52. Wang X, Li Y, Luo Y, Song X. Global and regional burden of nasopharyngeal cancer in older adults attributable to smoking and high alcohol use from 1990 to 2021. Frontiers in Public Health 2025;13 View
  53. Li Y, Tian J, You Y, Ru C, Zheng R, Wang S, Bray F. Global variations and socioeconomic inequalities in lifetime risk of lip, oral cavity, and pharyngeal cancer: a population-based systematic analysis of GLOBOCAN 2022. International Journal of Surgery 2025;111(6):3698 View
  54. Huang W, Zhu H, Cao X, Zou G, Wang Z, Zong D. Lactic Acid Metabolism-Related Gene May Act as a Prognostic Predictor by FARS2 in Nasopharyngeal Carcinoma. American Journal of Rhinology & Allergy 2025;39(4):309 View
  55. Wang C, Huang B, Liang H, Chen W. Nasopharyngeal Carcinoma in Intensity‐Modulated Radiation Therapy Era: Competing‐Risk Analysis, Recurrence, and Postrecurrence Survival. Head & Neck 2025;47(11):3076 View
  56. Zhu Y, Xue F. Clinical outcomes and prognostic factors of stereotactic body radiation therapy in metastatic nasopharyngeal carcinoma. Therapeutic Advances in Medical Oncology 2025;17 View
  57. Zhang H, Xue R, Kong X, Zhao M, Jin Z. Global, regional, and national burden and projections to 2050 of occupational carcinogen-attributable nasopharyngeal and laryngeal cancer: a comprehensive analysis from the GBD 2021 study. Frontiers in Public Health 2025;13 View
  58. Chen X, Xia W, Xu Z, Suo Y, Xie L. Trends in incidence and mortality of nasopharyngeal cancer in China (2004–2018): an age-period-cohort analysis. Frontiers in Oncology 2025;15 View
  59. Hu R, Li T, Shi Z, Feng E, Yang X, Yang J, Lin F, Ren Y, Li X. Anti-ferroptosis: A Promising Therapeutic Approach in Nasopharyngeal Carcinoma. Frontiers in Bioscience-Landmark 2025;30(6) View
  60. Sun H, Duan J, Zhu J, Li Z, Liu Y, Liu C, Li J, Shi Z, Li N, Gong J, Li X, Wang Z, Li D, Shi M, Zhao L. A novel multimodal adaptive delineation model for primary tumors and lymph node metastases in multi-center nasopharyngeal carcinoma radiotherapy. Computer Methods and Programs in Biomedicine 2025;270:108965 View
  61. Qiang J, Qiu T, Yang Y, Xu B, Huang H, Li X, Ma R, Lu Y, Dong Z. ALDH2 inhibits angiogenesis in esophageal squamous cell carcinoma by suppressing the NOTCH1/PI3K/Akt signaling pathway. Cellular Signalling 2025;135:112025 View
  62. Meirhaeghe M, Balfour H. Epstein-Barr virus (EBV) infection and its sequelae in the immunocompetent host. Journal of Clinical Virology 2025;180:105854 View
  63. Lu Z, Yang S, Dai M, Wu G, Wang F, Zhang K. Global burden of nasopharyngeal carcinoma attributable to alcohol use: a 1990–2021 analysis with projections to 2040. Frontiers in Public Health 2025;13 View
  64. Hua Y, Zhou S, Xu W, Cao Y, Sun X, Chao M, Cheng M, Tang Y. The Impact of Whole-Course Immunonutrition Management on Patients With Stage III and IV Nasopharyngeal Carcinoma Undergoing Concurrent Chemoradiotherapy: A Randomized Controlled Trial. Nutrition and Cancer 2025;77(9):1035 View
  65. Li Y, Chen Q, Li M, Si L, Guo Y, Xiong Y, Wang Q, Qin Y, Xu L, Smagt P, Wang K, Tang J, Chen N. A dataset of primary nasopharyngeal carcinoma MRI with multi-modalities segmentation. Scientific Data 2025;12(1) View
  66. Kim J, Lee Y, Kim S, Park J. Novel Therapeutic Development for Nasopharyngeal Carcinoma. Current Oncology 2025;32(9):479 View
  67. Jean-Joseph J, Westerhausen C, Doescher J, Maerkl B, Roushan Z, Neu M, Janzen T, Kahl K, Stueben G, Balagiannis N. Development and Validation of the Augsburg Nasopharyngeal Applicator: Enhancing Efficacy in Nasal Route Brachytherapy. Advances in Radiation Oncology 2025;10(11):101896 View
  68. Kouhen F, Chahid M, Gouache H, Errafiy N, Maghous A. Advancements in nasopharyngeal carcinoma radiotherapy: Dosimetric evaluation of arc therapy with hippocampal sparing. Cancer Treatment and Research Communications 2025;45:100983 View
  69. Li X, Zhang Y, An Q, Su S, Wang Y, Bai L, Zeng J, Xu X, Wong W, Wang Y, Li C. A Biothiol‐Reactive and Mitochondria‐Targeting Photosensitizer for Dual‐Modal Antitumor Treatment Combining Photodynamic and Nitric Oxide Therapies. Advanced Functional Materials 2025 View
  70. Zhang W, Meng Y, Zhang P, Tian D, Zeng X, Dong M, He L. PD-1 inhibitor combined with TPF induction chemotherapy in locally advanced nasopharyngeal carcinoma: a retrospective study of efficacy and safety. Frontiers in Immunology 2025;16 View
  71. Li W, Song J, Wu G, Dong M, Liao Y, Huang Z, Chen F, Huang W. Dynamic contrast-enhanced magnetic resonance imaging-based radiomics for predicting programmed death ligand 1 expression in nasopharyngeal carcinoma. BMC Medical Imaging 2025;25(1) View
  72. Zhang Y, Zhang Q, Wang L, Hu Y. The value of second-generation gene sequencing in lung cancer immunotherapy with concurrent infections. BMC Cancer 2025;25(1) View
  73. Wong J, Ng A, Tan L, Wong J. Timing or criteria to trigger adaptive radiotherapy (ART) for nasopharyngeal carcinoma (NPC): A systematic review. Physica Medica 2025;139:105203 View
  74. Wang Y, Zhang X, Yang W, Liu X, Xie S, Zhang L, Xiao X, Xie F, Zhu J, Lin H, Liu X, Xiong L. Caveolin-1 drives ferroptosis in MDSCs via PKA-DRP1-mediated ER‒mitochondria crosstalk to shape breast cancer immunosuppression. Free Radical Biology and Medicine 2026;242:601 View
  75. Huang J, MSocSc S, MSocSc M, Chan S, Yuan J, Zhang L, Chenwen Zhong C, Xu W, Zheng Z, Chen Z, Chan J, Wong M. Incidence, Risk Factors, and Epidemiological Trends of Head and Neck Cancer: A Global Analysis. MedComm 2025;6(11) View
  76. Lin G, Mo Q, Han L, Sun S, Xiao Z, Zhang W. Development of machine learning models for survival prediction in nasopharyngeal carcinoma using population-based data. Discover Oncology 2025;16(1) View
  77. Das A, Sahoo S, Thakur A. Unveiling Occult Nasopharyngeal (Undifferentiated) Carcinoma: A Case Series Highlighting the Worth of Fine-Needle Aspiration Cytology as a Frontline Diagnostic Tool for Hidden Lethal Malignancies. Acta Cytologica 2025:1 View
  78. Yang M, Mao S, Duan J, Xiao P. The antitumor mechanism of polysaccharides through regulating the microbiota-metabolism-immune axis and their clinical application strategies. Carbohydrate Polymers 2026;374:124723 View
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Books/Policy Documents

  1. Al-Ashqar R, Khalil H. Current Rhinology. View

Conference Proceedings

  1. Guo X, Yang X, Wang Y, Li J, Wang H, Gou J, Du X, Li S, Lu Y, Wang Y, Zou C. Sixth International Conference on Optoelectronic Science and Materials (ICOSM 2024). Advances in light-responsive nanoenzymes for tumor therapy View