This paper is in the following e-collection/theme issue:

Protocols for Public Health Research and Surveillance (69) JMIR Theme Issue: COVID-19 Special Issue (2461) Big Data (245) eHealth Infrastructures (357) Electronic Health Records (1068) Secondary Use of Clinical Data for Research and Surveillance (375) Infectious Diseases (non-STD/STI) (1592) Outbreak and Pandemic Preparedness and Management (1743) Surveillance Systems (466) Theme Issue: Novel Coronavirus (COVID-19) Outbreak Rapid Reports (1520)

Published on in Vol 6, No 3 (2020): Jul-Sep

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/19773, first published .
The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms

The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms

The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to Develop Extended COVID-19 Surveillance and Trial Platforms

Authors of this article:

Simon de Lusignan1, 2 Author Orcid Image ;   Nicholas Jones1 Author Orcid Image ;   Jienchi Dorward1 Author Orcid Image ;   Rachel Byford1 Author Orcid Image ;   Harshana Liyanage1 Author Orcid Image ;   John Briggs1 Author Orcid Image ;   Filipa Ferreira1 Author Orcid Image ;   Oluwafunmi Akinyemi1 Author Orcid Image ;   Gayatri Amirthalingam3 Author Orcid Image ;   Chris Bates4 Author Orcid Image ;   Jamie Lopez Bernal3 Author Orcid Image ;   Gavin Dabrera3 Author Orcid Image ;   Alex Eavis5 Author Orcid Image ;   Alex J Elliot6 Author Orcid Image ;   Michael Feher1 Author Orcid Image ;   Else Krajenbrink2 Author Orcid Image ;   Uy Hoang1 Author Orcid Image ;   Gary Howsam2 Author Orcid Image ;   Jonathan Leach2 Author Orcid Image ;   Cecilia Okusi1 Author Orcid Image ;   Brian Nicholson1 Author Orcid Image ;   Philip Nieri1 Author Orcid Image ;   Julian Sherlock1 Author Orcid Image ;   Gillian Smith6 Author Orcid Image ;   Mark Thomas2 Author Orcid Image ;   Nicholas Thomas2 Author Orcid Image ;   Manasa Tripathy1 Author Orcid Image ;   William Victor2 Author Orcid Image ;   John Williams1 Author Orcid Image ;   Ian Wood2, 5 Author Orcid Image ;   Maria Zambon3 Author Orcid Image ;   John Parry4 Author Orcid Image ;   Shaun O’Hanlon5 Author Orcid Image ;   Mark Joy1 Author Orcid Image ;   Chris Butler1 Author Orcid Image ;   Martin Marshall2 Author Orcid Image ;   FD Richard Hobbs1 Author Orcid Image
Article Authors Cited by (37) Tweetations (6) Metrics

Journals

  1. de Lusignan S, Lopez Bernal J, Byford R, Amirthalingam G, Ferreira F, Akinyemi O, Andrews N, Campbell H, Dabrera G, Deeks A, Elliot A, Krajenbrink E, Liyanage H, McGagh D, Okusi C, Parimalanathan V, Ramsay M, Smith G, Tripathy M, Williams J, Victor W, Zambon M, Howsam G, Nicholson B, Tzortziou Brown V, Butler C, Joy M, Hobbs F. Influenza and Respiratory Virus Surveillance, Vaccine Uptake, and Effectiveness at a Time of Cocirculating COVID-19: Protocol for the English Primary Care Sentinel System for 2020-2021. JMIR Public Health and Surveillance 2021;7(2):e24341 View
  2. de Lusignan S, Liyanage H, McGagh D, Jani B, Bauwens J, Byford R, Evans D, Fahey T, Greenhalgh T, Jones N, Mair F, Okusi C, Parimalanathan V, Pell J, Sherlock J, Tamburis O, Tripathy M, Ferreira F, Williams J, Hobbs F. COVID-19 Surveillance in a Primary Care Sentinel Network: In-Pandemic Development of an Application Ontology. JMIR Public Health and Surveillance 2020;6(4):e21434 View
  3. Sheppard J, Nicholson B, Lee J, McGagh D, Sherlock J, Koshiaris C, Oke J, Jones N, Hinton W, Armitage L, Van Hecke O, Lay-Flurrie S, Bankhead C, Liyanage H, Williams J, Ferreira F, Feher M, Ashworth A, Joy M, de Lusignan S, Hobbs F. Association Between Blood Pressure Control and Coronavirus Disease 2019 Outcomes in 45 418 Symptomatic Patients With Hypertension. Hypertension 2021;77(3):846 View
  4. Butler C, Dorward J, Yu L, Gbinigie O, Hayward G, Saville B, Van Hecke O, Berry N, Detry M, Saunders C, Fitzgerald M, Harris V, Patel M, de Lusignan S, Ogburn E, Evans P, Thomas N, Hobbs F. Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. The Lancet 2021;397(10279):1063 View
  5. Prado N, Biscarde D, Pinto Junior E, Santos H, Mota S, Menezes E, Oliveira J, Santos A. Ações de vigilância à saúde integradas à Atenção Primária à Saúde diante da pandemia da COVID-19: contribuições para o debate. Ciência & Saúde Coletiva 2021;26(7):2843 View
  6. Feher M, Hinton W, Forbes A, Munro N, Joy M, Wheeler D, de Lusignan S. Sodium-Glucose Cotransporter-2 Inhibitor and Glucagon-Like Peptide-1 Receptor Agonist Combination Therapy in Type 2 Diabetes: Protocol for a Kidney End Points Real-world Study (COMBi-KID Study). JMIR Research Protocols 2022;11(7):e34206 View
  7. Reeves J, Pageler N, Wick E, Melton G, Tan Y, Clay B, Longhurst C. The Clinical Information Systems Response to the COVID-19 Pandemic. Yearbook of Medical Informatics 2021;30(01):105 View
  8. Hoang U, Button E, Armstrong M, Okusi C, Ellis J, Zambon M, Anand S, Delanerolle G, Hobbs F, van Summeren J, Paget J, de Lusignan S. Assessing the Clinical and Socioeconomic Burden of Respiratory Syncytial Virus in Children Aged Under 5 Years in Primary Care: Protocol for a Prospective Cohort Study in England and Report on the Adaptations of the Study to the COVID-19 Pandemic. JMIR Research Protocols 2022;11(8):e38026 View
  9. Smith G, Harcourt S, Hoang U, Lemanska A, Elliot A, Morbey R, Hughes H, Lake I, Edeghere O, Oliver I, Sherlock J, Amlôt R, de Lusignan S. Mental Health Presentations Across Health Care Settings During the First 9 Months of the COVID-19 Pandemic in England: Retrospective Observational Study. JMIR Public Health and Surveillance 2022;8(8):e32347 View
  10. Bagaria J, Jansen T, Marques D, Hooiveld M, McMenamin J, de Lusignan S, Vilcu A, Meijer A, Rodrigues A, Brytting M, Mazagatos C, Cogdale J, van der Werf S, Dijkstra F, Guiomar R, Enkirch T, Valenciano M. Rapidly adapting primary care sentinel surveillance across seven countries in Europe for COVID-19 in the first half of 2020: strengths, challenges, and lessons learned. Eurosurveillance 2022;27(26) View
  11. Whitaker H, Tsang R, Byford R, Andrews N, Sherlock J, Sebastian Pillai P, Williams J, Button E, Campbell H, Sinnathamby M, Victor W, Anand S, Linley E, Hewson J, DArchangelo S, Otter A, Ellis J, Hobbs R, Howsam G, Zambon M, Ramsay M, Brown K, de Lusignan S, Amirthalingam G, Lopez Bernal J. Pfizer-BioNTech and Oxford AstraZeneca COVID-19 vaccine effectiveness and immune response amongst individuals in clinical risk groups. Journal of Infection 2022;84(5):675 View
  12. Mughal F, Atherton H, Reeve J, Mallen C. Academic primary care: challenges and opportunities. British Journal of General Practice 2022;72(716):104 View
  13. Nicholson B, Ordóñez-Mena J, Lay-Flurrie S, Sheppard J, Liyanage H, McGagh D, Sherlock J, Williams J, Smith M, Drakesmith C, Thomas N, Morris E, Perera R, de Lusignan S, Hobbs F, Bankhead C. Consultations for clinical features of possible cancer and associated urgent referrals before and during the COVID-19 pandemic: an observational cohort study from English primary care. British Journal of Cancer 2022;126(6):948 View
  14. Delanerolle G, Williams R, Stipancic A, Byford R, Forbes A, Tsang R, Anand S, Bradley D, Murphy S, Akbari A, Bedston S, Lyons R, Owen R, Torabi F, Beggs J, Chuter A, Balharry D, Joy M, Sheikh A, Hobbs F, de Lusignan S. Methodological Issues in Using a Common Data Model of COVID-19 Vaccine Uptake and Important Adverse Events of Interest: Feasibility Study of Data and Connectivity COVID-19 Vaccines Pharmacovigilance in the United Kingdom. JMIR Formative Research 2022;6(8):e37821 View
  15. Brown J, Bhatnagar M, Gordon H, Goodner J, Cobb J, Lutrick K. An Electronic Data Capture Tool for Data Collection During Public Health Emergencies: Development and Usability Study. JMIR Human Factors 2022;9(2):e35032 View
  16. Lemanska A, Price C, Jeffreys N, Byford R, Dambha-Miller H, Fan X, Hinton W, Otter S, Rice R, Stunt A, Whyte M, Faithfull S, de Lusignan S, Siddiqi T. BMI and HbA1c are metabolic markers for pancreatic cancer: Matched case-control study using a UK primary care database. PLOS ONE 2022;17(10):e0275369 View
  17. Tsang R, Joy M, Byford R, Robertson C, Anand S, Hinton W, Mayor N, Kar D, Williams J, Victor W, Akbari A, Bradley D, Murphy S, O’Reilly D, Owen R, Chuter A, Beggs J, Howsam G, Sheikh A, Hobbs F, de Lusignan S. Adverse events following first and second dose COVID-19 vaccination in England, October 2020 to September 2021: a national vaccine surveillance platform self-controlled case series study. Eurosurveillance 2023;28(3) View
  18. Leston M, Elson W, Watson C, Lakhani A, Aspden C, Bankhead C, Borrow R, Button E, Byford R, Elliot A, Fan X, Hoang U, Linley E, Macartney J, Nicholson B, Okusi C, Ramsay M, Smith G, Smith S, Thomas M, Todkill D, Tsang R, Victor W, Williams A, Williams J, Zambon M, Howsam G, Amirthalingam G, Lopez-Bernal J, Hobbs F, de Lusignan S. Representativeness, Vaccination Uptake, and COVID-19 Clinical Outcomes 2020-2021 in the UK Oxford-Royal College of General Practitioners Research and Surveillance Network: Cohort Profile Summary. JMIR Public Health and Surveillance 2022;8(12):e39141 View
  19. Vasileiou E, Shi T, Kerr S, Robertson C, Joy M, Tsang R, McGagh D, Williams J, Hobbs R, de Lusignan S, Bradley D, OReilly D, Murphy S, Chuter A, Beggs J, Ford D, Orton C, Akbari A, Bedston S, Davies G, Griffiths L, Griffiths R, Lowthian E, Lyons J, Lyons R, North L, Perry M, Torabi F, Pickett J, McMenamin J, McCowan C, Agrawal U, Wood R, Stock S, Moore E, Henery P, Simpson C, Sheikh A. Investigating the uptake, effectiveness and safety of COVID-19 vaccines: protocol for an observational study using linked UK national data. BMJ Open 2022;12(2):e050062 View
  20. Sivan M, Greenhalgh T, Darbyshire J, Mir G, O'Connor R, Dawes H, Greenwood D, O’Connor D, Horton M, Petrou S, de Lusignan S, Curcin V, Mayer E, Casson A, Milne R, Rayner C, Smith N, Parkin A, Preston N, Delaney B. LOng COvid Multidisciplinary consortium Optimising Treatments and servIces acrOss the NHS (LOCOMOTION): protocol for a mixed-methods study in the UK. BMJ Open 2022;12(5):e063505 View
  21. de Lusignan S, Tsang R, Akinyemi O, Lopez Bernal J, Amirthalingam G, Sherlock J, Smith G, Zambon M, Howsam G, Joy M. Adverse Events of Interest Following Influenza Vaccination in the First Season of Adjuvanted Trivalent Immunization: Retrospective Cohort Study. JMIR Public Health and Surveillance 2022;8(3):e25803 View
  22. Ndayishimiye C, Lopes H, Middleton J. A systematic scoping review of digital health technologies during COVID-19: a new normal in primary health care delivery. Health and Technology 2023;13(2):273 View
  23. Tsang R, Agrawal U, Joy M, Byford R, Robertson C, Anand S, Hinton W, Mayor N, Kar D, Williams J, Victor W, Akbari A, Bradley D, Murphy S, O’Reilly D, Owen R, Chuter A, Beggs J, Howsam G, Sheikh A, Richard Hobbs F, Lusignan S. Adverse events after first and second doses of COVID-19 vaccination in England: a national vaccine surveillance platform self-controlled case series study. Journal of the Royal Society of Medicine 2024;117(4):134 View
  24. Whitaker H, Tsang R, Byford R, Aspden C, Button E, Sebastian Pillai P, Jamie G, Kar D, Williams J, Sinnathamby M, Marsden G, Elson W, Leston M, Anand S, Okusi C, Fan X, Linley E, Rowe C, DArcangelo S, Otter A, Ellis J, Hobbs F, Tzortziou-Brown V, Zambon M, Ramsay M, Brown K, Amirthalingam G, Andrews N, de Lusignan S, Lopez Bernal J. COVID-19 vaccine effectiveness against hospitalisation and death of people in clinical risk groups during the Delta variant period: English primary care network cohort study. Journal of Infection 2023;87(4):315 View
  25. Taramasco C, Rimassa C. Architecture Assessment of the Chilean Epidemiological Surveillance System for Notifiable Diseases (EPIVIGILA): Qualitative Study. JMIR Formative Research 2023;7:e34387 View
  26. Meza-Torres B, Forbes A, Elson W, Kar D, Jamie G, Hinton W, Fan X, Byford R, Feher M, Whyte M, Joy M, de Lusignan S. Hepatitis A Vaccination Coverage Among People With Chronic Liver Disease in England (HEALD): Protocol for a Retrospective Cohort Study. JMIR Research Protocols 2023;12:e51861 View
  27. Hoang U, Delanerolle G, Fan X, Aspden C, Byford R, Ashraf M, Haag M, Elson W, Leston M, Anand S, Ferreira F, Joy M, Hobbs R, de Lusignan S. A Profile of Influenza Vaccine Coverage for 2019-2020: Database Study of the English Primary Care Sentinel Cohort. JMIR Public Health and Surveillance 2024;10:e39297 View
  28. Meeraus W, Joy M, Ouwens M, Taylor K, Venkatesan S, Dennis J, Tran T, Dashtban A, Fan X, Williams R, Morris T, Carty L, Kar D, Hoang U, Feher M, Forbes A, Jamie G, Hinton W, Sanecka K, Byford R, Anand S, Hobbs F, Clifton D, Pollard A, Taylor S, de Lusignan S. AZD1222 effectiveness against severe COVID-19 in individuals with comorbidity or frailty: The RAVEN cohort study. Journal of Infection 2024;88(4):106129 View
  29. Heath L, Ordóñez-Mena J, Aveyard P, Wherton J, Nicholson B, Stevens R. How has the COVID-19 pandemic affected the delivery of preventive healthcare? An interrupted time series analysis of adults in English primary care from 2018 to 2022. Preventive Medicine 2024;181:107923 View
  30. Jamie G, Elson W, Kar D, Wimalaratna R, Hoang U, Meza-Torres B, Forbes A, Hinton W, Anand S, Ferreira F, Byford R, Ordonez-Mena J, Agrawal U, de Lusignan S. Phenotype execution and modeling architecture to support disease surveillance and real-world evidence studies: English sentinel network evaluation. JAMIA Open 2024;7(2) View
  31. Kar D, Taylor K, Joy M, Venkatesan S, Meeraus W, Taylor S, Anand S, Ferreira F, Jamie G, Fan X, de Lusignan S. Creating a Modified Version of the Cambridge Multimorbidity Score to Predict Mortality in People Older Than 16 Years: Model Development and Validation. Journal of Medical Internet Research 2024;26:e56042 View
  32. Sheppard J, Temple E, Wang A, Smith A, Pollock S, Ford G, Hobbs F, Kenealy N, Little P, Lown M, de Lusignan S, Mant J, McCartney D, Payne R, Williams M, Yu L, McManus R. Effect of antihypertensive deprescribing on hospitalisation and mortality: long-term follow-up of the OPTiMISE randomised controlled trial. The Lancet Healthy Longevity 2024;5(8):e563 View
  33. Mughal F, Khunti K, Mallen C. The impact of COVID-19 on primary care. Journal of Family Medicine and Primary Care 2021;10(12):4345 View
  34. Hayward G, Butler C, Yu L, Saville B, Berry N, Dorward J, Gbinigie O, van Hecke O, Ogburn E, Swayze H, Bongard E, Allen J, Tonner S, Rutter H, Tonkin-Crine S, Borek A, Judge D, Grabey J, de Lusignan S, Thomas N, Evans P, Andersson M, Llewelyn M, Patel M, Hopkins S, Hobbs F. Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk. BMJ Open 2021;11(6):e046799 View
  35. Leston M, Kar D, Forbes A, Jamie G, Wimalaratna R, Jiwani G, Ordóñez-Mena J, Stewart D, Whitaker H, Joy M, Lee L, Hobbs F, de Lusignan S. Developing a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network. Frontiers in Immunology 2024;15 View
  36. Smith A, Tucker K, Barnes R, Drakesmith C, Agwunobi A, Bateman P, Forbes A, de Lusignan S, Ford G, Fujiwara T, Hobbs F, Koshiaris C, Mant J, McKinstry B, Pollock S, Rice C, Yang Y, McManus R. A service evaluation of the implementation of a novel digital intervention for hypertension self-monitoring and management system in primary care (SHIP): protocol for a mixed methods study. BMC Cardiovascular Disorders 2024;24(1) View

Books/Policy Documents

  1. Gupta M, Kalra R. System Design for Epidemics Using Machine Learning and Deep Learning. View