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Preclinical Cognitive Markers of Alzheimer Disease and Early Diagnosis Using Virtual Reality and Artificial Intelligence: Literature Review

Preclinical Cognitive Markers of Alzheimer Disease and Early Diagnosis Using Virtual Reality and Artificial Intelligence: Literature Review

hippocampus Thickness of the right entorhinal cortex Average thickness of seven cortical regions AD-related atrophy Low CR/dnormal (n=108) High CR/normal (n=126) Low CR/progressed (n=41) High CR/normal (n=25) Aß-positive (n=71) Aß-negative (n=5205) Free and Cued Selective Reminding Test – Free Recall Logical memory Sequencing task High p-tau/amyloid beta 42 Low p-tau/amyloid beta 42 Healthy control (n=20) Mild cognitive impairment (n=18) AD (n=20) Free and Cued Selective Reminding Test Memory Binding Test Rey-Osterreieth

María de la Paz Scribano Parada, Fátima González Palau, Sonia Valladares Rodríguez, Mariano Rincon, Maria José Rico Barroeta, Marta García Rodriguez, Yolanda Bueno Aguado, Ana Herrero Blanco, Estela Díaz-López, Margarita Bachiller Mayoral, Raquel Losada Durán

JMIR Med Inform 2025;13:e62914