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Clinics that allow study recruitment among staff and patients, establish a DSA for the transfer of patient participant methadone treatment chart data at the conclusion of the 20-month trial, and identify a clinic “champion” to assist with study enrollment and study contact will be eligible for randomization as described below.
Following clinic enrollment, each clinic champion will post recruitment flyers in staff-only areas (for staff participants) and in patient-only areas (for patient participants).
JMIR Res Protoc 2025;14:e69829
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While previous studies have examined the utility of mobile apps, social media, e-consenting tools, blockchain technology, web-based programs, and online messaging to improve clinical trial enrollment, few have specifically addressed the unique barriers faced by the young adult population. Yet, digital modalities have grown in popularity among this population for many indications including disease interventions and browsing emerging health information [13-15].
J Med Internet Res 2025;27:e70852
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After obtaining informed consent, supported by the REDCap e-Consent Framework feature, participants will be automatically directed to baseline questionnaire surveys, for which REDCap auto-calculates the scores. Following completion of the baseline assessment, the participant will be randomized to their respective treatment conduction using the Randomization Module.
JMIR Res Protoc 2025;14:e65770
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Reference 46: Patient-centered design of an e-mental health appDigital Mental Health Interventions, e-Mental Health and Cyberpsychology
JMIR Hum Factors 2025;12:e65889
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