Identifying Data-Driven Clinical Subgroups for Cervical Cancer Prevention With Machine Learning: Population-Based, External, and Diagnostic Validation Study

Zhen Lu   ¹ , MSc ;   Binhua Dong   ^{2, 3} , MSc ;   Hongning Cai   ⁴ , MSc ;   Tian Tian   ⁵ , PhD ;   Junfeng Wang   ⁶ , PhD ;   Leiwen Fu   ⁷ , PhD ;   Bingyi Wang   ^{8, 9} , PhD ;   Weijie Zhang   ¹ , BD ;   Shaomei Lin   ¹⁰ , BD ;   Xunyuan Tuo   ¹¹ , MSc ;   Juntao Wang   ¹² , MSc ;   Tianjie Yang   ¹³ , MSc ;   Xinxin Huang   ¹⁴ , MSc ;   Zheng Zheng   ¹³ , MSc ;   Huifeng Xue   ¹⁵ , MSc ;   Shuxia Xu   ¹⁶ , BD ;   Siyang Liu   ¹ , PhD ;   Pengming Sun   ^{2, 3, 17} , MD, PhD ;   Huachun Zou   ^{18, 19, 20} , PhD

¹ School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China

² Department of Gynecology, Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

³ Fujian Key Laboratory of Women and Children’s Critical Diseases Research, Fuzhou, China

⁴ Department of Gynecology, Maternal and Child Health Hospital of Hubei Province (Women and Children's Hospital of Hubei Province) Wuhan, Wuhan, China

⁵ School of Public Health, Xinjiang Medical University, Urumqi, China

⁶ Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

⁷ Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China

⁸ Institute for HIV/AIDS Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China

⁹ Department of HIV/AIDS Control and Prevention, Guangdong Provincial Academy of Preventive Medicine, Guangzhou, China

¹⁰ Department of Gynecology, Shunde Women's and Children's Hospital of Guangdong Medical University, Foshan, China

¹¹ Department of Gynecology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China

¹² Department of Gynecology, Guiyang Maternal and Child Health Care Hospital, Guiyang, China

¹³ Department of Gynecology, Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, China

¹⁴ The Ministry of Health, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

¹⁵ Center for Cervical Disease Diagnosis and Treatment, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

¹⁶ Department of Pathology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China

¹⁷ School of Group Medicine and Public Health, Peking Union Medical College, Beijing, China

¹⁸ School of Public Health, Fudan University, Shanghai, China

¹⁹ Shenzhen Campus, Sun Yat-sen University, Shenzhen, China

²⁰ Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China