Association of Rest-Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population: Prospective Cohort Study

Shahab Haghayegh   ^{1, 2, 3, 4} , MSc, PhD ;   Chenlu Gao   ^{1, 2, 3, 4} , PhD ;   Elizabeth Sugg   ¹ , BA ;   Xi Zheng   ⁴ , MSc ;   Hui-Wen Yang   ⁴ , PhD ;   Richa Saxena   ^{1, 2, 3} , PhD ;   Martin K Rutter   ^{5, 6} , MD ;   Michael Weedon   ⁷ , PhD ;   Agustin Ibanez   ⁸ , PhD ;   David A Bennett   ⁹ , MD ;   Peng Li   ^{1, 2, 3, 4} , PhD ;   Lei Gao   ^{1, 2 *} , MD ;   Kun Hu   ^{1, 2, 3, 4 *} , PhD

¹ Massachusetts General Hospital, Boston, MA, United States

² Harvard Medical School, Boston, MA, United States

³ Broad Institute, Cambridge, MA, United States

⁴ Brigham and Women's Hospital, Boston, MA, United States

⁵ Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom

⁶ Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom

⁷ University of Exeter, Exeter, United Kingdom

⁸ Adolfo Ibañez University, Santiago, Chile

⁹ RUSH University, Chicago, IL, United States

*these authors contributed equally