Comparing the Effectiveness, Tolerability, and Acceptability of Heated Tobacco Products and Refillable Electronic Cigarettes for Cigarette Substitution (CEASEFIRE): Randomized Controlled Trial

Pasquale Caponnetto   ^{1, 2} , PhD ;   Davide Campagna   ^{1, 3, 4, 5} , MD ;   Marilena Maglia   ³ , DPhil ;   Francesca Benfatto   ³ , BA ;   Rosalia Emma   ⁴ , PhD ;   Massimo Caruso   ^{1, 6} , PhD ;   Grazia Caci   ⁷ , MD ;   Barbara Busà   ⁸ , MD ;   Alfio Pennisi   ⁹ , MD ;   Maurizio Ceracchi   ¹⁰ , MD ;   Marcello Migliore   ^{11, 12} , MD ;   Maria Signorelli   ¹³ , PhD

¹ Center of Excellence for the Acceleration of Harm Reduction, University of Catania, Catania, Italy

² Department of Educational Sciences, University of Catania, Catania, Italy

³ Eclat Spin off srl, University of Catania, Catania, Italy

⁴ Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy

⁵ Unità Operativa Complessa Medicina Accettazione Urgenza, University Teaching Hospital, University of Catania, Catania, Italy

⁶ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

⁷ Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

⁸ Dipartimento Emergenza-Urgenza, Farmacia presidio ospedaliero centro Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi, Catania, Italy

⁹ Department of Respiratory Medicine, Hospital Clinics "Musumeci-Gecas", Catania, Italy

¹⁰ Fullcro Srl, Roma, Italy

¹¹ Department of Surgery and Medical Specialties, University of Catania, Catania, Italy

¹² Minimally Invasive Thoracic Surgery and New Technology, University Hospital of Catania, Catania, Italy

¹³ Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy