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Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial

Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial

It also did not perform prospective assessment of several factors important to evaluate the proposed conceptual framework. In this research project, 3 Clinical and Translational Science Awards (CTSA) programs (Mayo Clinic, University of Michigan, and Yale University) leveraged the conceptual framework for UPOU to investigate how the patient characteristics, practice environment characteristics, and opioid prescriber characteristics facilitate or impede UPOU.

W Michael Hooten, Darin J Erickson, Marek Chawarski, Natalie A Scholz, Jennifer F Waljee, Chad M Brummett, Molly M Jeffery

JMIR Res Protoc 2025;14:e72032

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

We thus performed an exploratory, prospective, open-label, parallel, single-center, randomized controlled trial (RCT) to investigate the effectiveness of CGM on short-term, in-hospital mortality among frail and critically ill patients with COVID-19. This is an exploratory, prospective, open-label, parallel, single-center RCT.

Jiawei Shang, Ziming Yuan, Zuoyan Zhang, Quanhong Zhou, Yan Zou, Wei Wang

J Med Internet Res 2025;27:e67012

Detection of Urinary Misfolded Proteins for Imminent Prediction of Preeclampsia in Pregnant Women With Suspected Cases: Protocol for a Prospective Noninterventional Study

Detection of Urinary Misfolded Proteins for Imminent Prediction of Preeclampsia in Pregnant Women With Suspected Cases: Protocol for a Prospective Noninterventional Study

This is a prospective noninterventional clinical trial planned in accordance with the principles of evidence-based medicine using the PICO (patient, problem, or population; investigated condition; comparison; and outcome) criteria. The study procedure is outlined in Figure 1. Flowchart of participants with suspected preeclampsia (PE) in the trial. Eligible pregnant women will be enrolled, and consecutive urine samples will be collected at each visit.

Haiyang Tang, Yijia Tian, Jing Fang, Xiaoying Yuan, Minli Yao, Yujia Wang, Yan Feng, Jia Shu, Yan Ni, Ying Yu, Yuanhe Wang, Ping Liang, Xingmin Li, Xiaoxia Bai

JMIR Res Protoc 2024;13:e54026

Feasibility of a Smartphone-Based Hearing Aid App for Mild-to-Moderate Hearing Loss: Prospective Multicenter Randomized Controlled Trial

Feasibility of a Smartphone-Based Hearing Aid App for Mild-to-Moderate Hearing Loss: Prospective Multicenter Randomized Controlled Trial

A prospective randomized controlled trial was conducted at 2 tertiary hospitals in South Korea (the Department of Otolaryngology, Seoul National University Hospital and the Department of Otolaryngology, The Catholic University of Korea, Seoul St. Mary’s Hospital) from August 2020 to November 2022. The inclusion criteria were (1) acquired symmetrical, sensorineural, and mild-to-moderate hearing loss; (2) current use of a smartphone; and (3) no previous experience with hearing amplification.

Sungmin Jo, Moo Kyun Park, Jae-Hyun Seo, Ki-eun Lee, Jae Sang Han, Ji Hyung Lim, Jun Ho Lee, Seung-Ha Oh

JMIR Mhealth Uhealth 2023;11:e46911

Using Presurgical Biopsychosocial Features to Develop an Advanced Clinical Decision-Making Support Tool for Predicting Recovery Trajectories in Patients Undergoing Total Knee Arthroplasty: Protocol for a Prospective Observational Study

Using Presurgical Biopsychosocial Features to Develop an Advanced Clinical Decision-Making Support Tool for Predicting Recovery Trajectories in Patients Undergoing Total Knee Arthroplasty: Protocol for a Prospective Observational Study

This study had a prospective observational design. Participants were involved in the study for a duration of 4 months, with data collection taking place at 2 time points during this period: within the month preceding their scheduled TKA and 3 months (12 weeks) following the TKA procedure. Figure 1 outlines the participants’ timeline for this study and the number of participants recruited and excluded at each stage. Participant timeline. TKA: total knee arthroplasty.

Karen Ribbons, Sarah Johnson, Elizabeth Ditton, Adrian Wills, Gillian Mason, Traci Flynn, Jodie Cochrane, Michael Pollack, Frederick Rohan Walker, Michael Nilsson

JMIR Res Protoc 2023;12:e48801

Real-time Symptom Assessment in Patients With Endometriosis: Psychometric Evaluation of an Electronic Patient-Reported Outcome Measure, Based on the Experience Sampling Method

Real-time Symptom Assessment in Patients With Endometriosis: Psychometric Evaluation of an Electronic Patient-Reported Outcome Measure, Based on the Experience Sampling Method

This prospective study was approved by the medical ethics committee of MUMC+ (Ref. No. 2019-1261). Patients with premenopausal endometriosis aged ≥18 years, diagnosed by physical examination, imaging techniques, or laparoscopy, were recruited at the outpatient gynecology department at MUMC+, a tertiary referral center, between December 2019 and November 2020. Furthermore, patients were recruited by advertisement on the website of the Dutch Endometriosis Foundation.

Esther van Barneveld, Arianne Lim, Nehalennia van Hanegem, Frits van Osch, Lisa Vork, Joanna Kruimel, Marlies Bongers, Carsten Leue

JMIR Form Res 2023;7:e29480

Matched Endoscopic Sleeve Gastroplasty and Laparoscopic Sleeve Gastrectomy Cases: Formative Cohort Study

Matched Endoscopic Sleeve Gastroplasty and Laparoscopic Sleeve Gastrectomy Cases: Formative Cohort Study

This is a substudy of a larger prospective cohort study (Universal Trial Number U1111-1216-8678) undertaken and reported according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist [22] and registered prospectively on March 6, 2018, at the Australia New Zealand Clinical Trials Registry (ACTRN12618000337279). The results of the larger study have been published elsewhere [21].

Skye Marshall, Graeme G Rich, Felicity Cohen, Asha Soni, Elizabeth Isenring

JMIR Form Res 2022;6(11):e29713

An Agreement of Antigen Tests on Oral Pharyngeal Swabs or Less Invasive Testing With Reverse Transcription Polymerase Chain Reaction for Detecting SARS-CoV-2 in Adults: Protocol for a Prospective Nationwide Observational Study

An Agreement of Antigen Tests on Oral Pharyngeal Swabs or Less Invasive Testing With Reverse Transcription Polymerase Chain Reaction for Detecting SARS-CoV-2 in Adults: Protocol for a Prospective Nationwide Observational Study

This research combines a retrospective study of analytical sensitivity and specificity with a prospective accuracy observational study. In the prospective part of the study, approximately 200 individuals testing positive for SARS-Co V-2 and 200 individuals testing negative for SARS-Co V-2 by routine SARS-Co V-2 testing will be subsequently retested with each RAT, with RT-PCR on deep oropharyngeal cavity swabs as the reference method.

Uffe Vest Schneider, Jenny Dahl Knudsen, Anders Koch, Nikolai Søren Kirkby, Jan Gorm Lisby

JMIR Res Protoc 2022;11(5):e35706