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Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study

Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study

From the extended-cosine models, we extracted measures of 24-hour robustness (pseudo-F statistic, indicating how well the observed data fits the 24-hour curve); activity onset time (up-mesor, the time which the modeled activity level passes the middle modeled rhythm height prior to the peak); and activity offset time (down-mesor or the time which the modeled activity level passes the middle modeled rhythm height prior to the nadir).

Caleb D Jones, Rachel Wasilko, Gehui Zhang, Katie L Stone, Swathi Gujral, Juleen Rodakowski, Stephen F Smagula

JMIR Aging 2025;8:e67294

Digital Health Intervention to Reduce Malnutrition Among Individuals With Gastrointestinal Cancer Receiving Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy: Feasibility, Acceptability, and Usability Trial

Digital Health Intervention to Reduce Malnutrition Among Individuals With Gastrointestinal Cancer Receiving Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy: Feasibility, Acceptability, and Usability Trial

Malnutrition is commonly observed among individuals with gastrointestinal (GI) cancer and can severely affect disease prognosis, quality of life, and survival [1,2]. Individuals with GI cancer are at high risk of developing peritoneal disease (PD), the metastasis of cancer to the abdominal cavity, which occurs in about 40% of patients with GI cancer [3].

Yu Chen Lin, Ryan Hagen, Benjamin D Powers, Sean P Dineen, Jeanine Milano, Emma Hume, Olivia Sprow, Sophia Diaz-Carraway, Jennifer B Permuth, Jeremiah Deneve, Amir Alishahi Tabriz, Kea Turner

JMIR Cancer 2025;11:e67108

Using Social Media Platforms to Raise Health Awareness and Increase Health Education in Pakistan: Structural Equation Modeling Analysis and Questionnaire Study

Using Social Media Platforms to Raise Health Awareness and Increase Health Education in Pakistan: Structural Equation Modeling Analysis and Questionnaire Study

Amid financial crises, health care awareness and education are known to be effective in reducing the disease burden rate [8]. There are several traditional efforts made by the Government of Pakistan Ministry of Health in the past to improve disease awareness and reduce the patient burden [24]. These include the following: Engaging community health workers in disseminating health information, especially in rural areas.

Malik Mamoon Munir, Nabil Ahmed

JMIR Hum Factors 2025;12:e65745

Using Large Language Models to Automate Data Extraction From Surgical Pathology Reports: Retrospective Cohort Study

Using Large Language Models to Automate Data Extraction From Surgical Pathology Reports: Retrospective Cohort Study

Large language models (LLMs) power a new generation of natural language processing (NLP) whereby deep neural networks are trained on a massive corpus of human text that are then deconstructed into vectorized embeddings that depict linguistic relationships in a numerical format appropriate for easy analysis [9].

Denise Lee, Akhil Vaid, Kartikeya M Menon, Robert Freeman, David S Matteson, Michael L Marin, Girish N Nadkarni

JMIR Form Res 2025;9:e64544

Identifying Unmet Needs of Informal Dementia Caregivers in Clinical Practice: User-Centered Development of a Digital Assessment Tool

Identifying Unmet Needs of Informal Dementia Caregivers in Clinical Practice: User-Centered Development of a Digital Assessment Tool

In addition, researchers argue that a focus on the detection of changes in family caregivers’ needs throughout disease progression is important [20,22]. Therefore, the aim of this study was to develop a digital unmet needs assessment tool that can be used in primary care settings. We conducted the study in collaboration with informal and formal caregivers and other stakeholders.

Olga A Biernetzky, Jochen René Thyrian, Melanie Boekholt, Matthias Berndt, Wolfgang Hoffmann, Stefan J Teipel, Ingo Kilimann

JMIR Aging 2025;8:e59942

Efficacy of a Digital Postoperative Rehabilitation Intervention in Patients With Primary Liver Cancer: Randomized Controlled Trial

Efficacy of a Digital Postoperative Rehabilitation Intervention in Patients With Primary Liver Cancer: Randomized Controlled Trial

If subsequent multi-factor analysis is required, multiple linear regression or logistic regression models are selected according to continuous-type or subtype dependent variables. Multiple interpolations were used for the analysis of missing data. P The study used mixed-effects linear regression models to examine the preliminary impact of the intervention while adjusting baseline characteristics.

Kaitao Yu, Baobing Yin, Ying Zhu, Hongdao Meng, Wenwei Zhu, Lu Lu, Junqiao Wang, Shugeng Chen, Jun Ni, Yifang Lin, Jie Jia

JMIR Mhealth Uhealth 2025;13:e59228

Determining the Prioritization of Behavior Change Techniques for Long-Term Stroke Rehabilitation: Delphi Survey Study

Determining the Prioritization of Behavior Change Techniques for Long-Term Stroke Rehabilitation: Delphi Survey Study

It is a serious health problem and one of the most common causes of death and acquired disability among adults [2], having “(...) the greatest disabling impact of any chronic disease” [3]. Further, only a small proportion of patients die in the acute stroke phase, leaving the majority with moderate to severe disability that can be mitigated through early and sustained rehabilitation interventions [4].

Agata Ewa Wróbel, Philip Cash, Anja Maier, John Paulin Hansen

Interact J Med Res 2025;14:e59172

Striking a Balance: Innovation, Equity, and Consistency in AI Health Technologies

Striking a Balance: Innovation, Equity, and Consistency in AI Health Technologies

This paper addresses the ambiguity faced by innovators and proposes models for evidence strategies, particularly focusing on the distinct regulatory challenges faced by the biopharma industry. At the time of this writing, Gartner [4] has placed the increasingly popular generative AI technology at the peak of inflated expectations for emerging technologies in 2024.

Eric Perakslis, Kimberly Nolen, Ethan Fricklas, Tracy Tubb

JMIR AI 2025;4:e57421

Clinical Benefits and Risks of Antiamyloid Antibodies in Sporadic Alzheimer Disease: Systematic Review and Network Meta-Analysis With a Web Application

Clinical Benefits and Risks of Antiamyloid Antibodies in Sporadic Alzheimer Disease: Systematic Review and Network Meta-Analysis With a Web Application

Until lately, the only available therapies for Alzheimer disease (AD) were related to symptomatic presentation, and this situation remains in most countries. Regulatory approvals of aducanumab (2021), lecanemab (2023), and donanemab (2024) in the United States have marked a new era in AD treatment, as these antibodies demonstrated the potential to modify disease progression by targeting amyloid β (Aβ), which involves toxic peptides deemed crucial in the AD pathophysiology [1].

Danko Jeremic, Juan D Navarro-Lopez, Lydia Jimenez-Diaz

J Med Internet Res 2025;27:e68454

Investigating Clinicians’ Intentions and Influencing Factors for Using an Intelligence-Enabled Diagnostic Clinical Decision Support System in Health Care Systems: Cross-Sectional Survey

Investigating Clinicians’ Intentions and Influencing Factors for Using an Intelligence-Enabled Diagnostic Clinical Decision Support System in Health Care Systems: Cross-Sectional Survey

They automatically extract key clinical features, dynamically matching them with disease-symptom associations in knowledge graphs. CDSS also incorporate evidence-based medical rules and updated clinical guidelines to emulate expert reasoning and assess potential causes, complications, and rare disease risks. Through interactive visualization interfaces, they present diagnostic rationales, risk alerts, and recommended diagnostic pathways, ensuring decision logic remains fully traceable [3].

Rui Zheng, Xiao Jiang, Li Shen, Tianrui He, Mengting Ji, Xingyi Li, Guangjun Yu

J Med Internet Res 2025;27:e62732