JMIR Public Health and Surveillance

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Noninvasive, Multimodal Inflammatory Biomarker Discovery for Systemic Inflammation (NOVA Study): Protocol for a Cross-Sectional Study

To address this research gap, we propose a proof-of-concept feasibility study (NOVA study) to evaluate the relationship between the levels of serum inflammatory biomarkers and those measured noninvasively in urine, sweat, saliva, exhaled breath, core body temperature, and stool in patients with systemic inflammation.

Jinjoo Shim, Sinziana Muraru, Rucsandra Dobrota, Elgar Fleisch, Oliver Distler, Filipe Barata

JMIR Res Protoc 2024;13:e62877

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Intensive, Real-Time Data Collection of Psychological and Physiological Stress During a 96-Hour Field Training Exercise at a Senior Military College: Feasibility and Acceptability Cohort Study

Feasibility was defined by a retention rate (>80%) and adherence rates (>70%) for the assessment measures [18,19], such as survey responses, saliva collections, sweat collection, and HRV sensor wear. Retention was defined as the percentage of participants who completed the baseline survey and completed the 96-hour FTX. The adherence to saliva sampling was defined as the percentage of the collected saliva sample out of a total of 12 collections (4 per day for 3 days).

Rachele Pojednic, Amy Welch, Margaret Thornton, Meghan Garvey, Tara Grogan, Walter Roberts, Garrett Ash

JMIR Form Res 2024;8:e60925

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Assessment of the Effective Sensitivity of SARS-CoV-2 Sample Pooling Based on a Large-Scale Screening Experience: Retrospective Analysis

Research on the detection of other respiratory viruses in saliva [25,26] and previous work by our group with saliva and SARS-Co V-2 [27] piqued our interest in this approach. Although there was no validated technique for using saliva samples at the beginning of this work and serious doubts about its suitability for diagnosing SARS-Co V-2, various studies had postulated saliva as the preferred alternative sample [24,28-31]. Erratic results were observed when comparing saliva and NPSs [24,32-34].

Jorge J Cabrera Alvargonzalez, Ana Larrañaga, Javier Martinez, Sonia Pérez Castro, Sonia Rey Cao, Carlos Daviña Nuñez, Víctor Del Campo Pérez, Carmen Duran Parrondo, Silvia Suarez Luque, Elena González Alonso, Alfredo José Silva Tojo, Jacobo Porteiro, Benito Regueiro

JMIR Public Health Surveill 2024;10:e54503

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Internet Tool to Support Self-Assessment and Self-Swabbing of Sore Throat: Development and Feasibility Study

At the end of this stage, we had a web-based tool that could be used to help with self-assessment of sore throat (and taking throat swabs and saliva samples).

Mark Lown, Kirsten A Smith, Ingrid Muller, Catherine Woods, Emma Maund, Kirsty Rogers, Taeko Becque, Gail Hayward, Michael Moore, Paul Little, Margaret Glogowska, Alastair Hay, Beth Stuart, Efi Mantzourani, Christopher R Wilcox, Natalie Thompson, Nick A Francis

J Med Internet Res 2023;25:e39791

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An Agreement of Antigen Tests on Oral Pharyngeal Swabs or Less Invasive Testing With Reverse Transcription Polymerase Chain Reaction for Detecting SARS-CoV-2 in Adults: Protocol for a Prospective Nationwide Observational Study

Saliva samples will be collected according to the manufacturer’s instructions. If no specific instruction is provided or for RT-PCR, the sample will be collected by instructing the person being tested to massage the glands on both sides of the jaw and them sampling the saliva produced from the parotid, submandibular, and sublingual glands.

Uffe Vest Schneider, Jenny Dahl Knudsen, Anders Koch, Nikolai Søren Kirkby, Jan Gorm Lisby

JMIR Res Protoc 2022;11(5):e35706

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Prevalence of SARS-CoV-2 Infection in Children by Antibody Detection in Saliva: Protocol for a Prospective Longitudinal Study (Coro-Buddy)

Interestingly, antibodies are also secreted by mucosal tissues, and SARS-Co V-2–specific antibodies can be detected in saliva and other body fluids [13]. Saliva sampling as a noninvasive method (ie, it does not cause disturbance) for SARS-Co V-2 antibody measurements and is an elegant approach to rapidly assess the prevalence of SARS-Co V-2 infection in vulnerable cohorts at numbers appropriate for epidemiologic investigations [14].

Yudi T Pinilla, Evelyn Friessinger, Johanna Marie Griesbaum, Lilith Berner, Constanze Heinzel, Käthe Elsner, Rolf Fendel, Jana Held, Andrea Kreidenweiss

JMIR Res Protoc 2021;10(10):e27739

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Effects of Alternative Offers of Screening Sigmoidoscopy and Colonoscopy on Utilization and Yield of Endoscopic Screening for Colorectal Neoplasms: Protocol of the DARIO Randomized Trial

Part III of the study builds up a liquid biobank from biosamples (blood, urine, stool, saliva) of study part II participants, with samples taken prior to endoscopy. The main objective of study part III is the evaluation of less invasive methods of CRC screening and further characterization of detected neoplasms and defining biomarkers or biomarker panels of different composition (such as proteins, metabolites, DNA, micro RNA, methylation markers) obtained via different -omics platforms. DARIO study design.

Petra Schrotz-King, Michael Hoffmeister, Peter Sauer, Anja Schaible, Hermann Brenner

JMIR Res Protoc 2020;9(8):e17516

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