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ABI can impact body functions and lead to impairments that are either visible (eg, reduced motor control) or invisible (eg, impaired memory, fatigue [1], ie, a profound sense of tiredness and a lack of mental and physical energy). Fatigue has been reported as one of the most common and challenging invisible consequences to manage [2].
J Med Internet Res 2025;27:e67658
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Anthracyclines, substances that play a leading role in chemotherapy against breast cancer, have an affinity for the inner membrane of the mitochondria, the place where the body’s energy is produced; therefore, this mechanism explains fatigue, atrophy, and muscle pain [21,22].
Various treatments are currently being studied to alleviate these side effects, including therapeutic exercise. Exercise provides short- and long-term benefits to reduce the symptoms that may appear during treatment in each patient.
JMIR Res Protoc 2025;14:e63891
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Not all CRs are acted upon, and some may justifiably be considered irrelevant or inapplicable [16,17], but increasingly GPs are disregarding pertinent or urgent CRs [18-20], a chronic negligence commonly referred to as “alert fatigue” [21].
J Med Internet Res 2025;27:e62763
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Most prevalent in patients with melanoma undergoing immunotherapy with ICIs are cancer-related fatigue (CRF) and emotional distress, affecting both health-related quality of life (HRQo L) and clinical outcome to immunotherapy [8,14-16]. Efforts to address CRF include exercise recommendation, psychosocial support, mindfulness-based interventions, and yoga, showing positive effects on fatigue, emotional distress, and HRQo L [14,15,17-23].
JMIR Cancer 2025;11:e58938
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We used the Multidimensional Fatigue Inventory (MFI) to assess the different dimensions of fatigue [41-43]. It is a short self-report questionnaire (5-10 minutes) based on 20 questions to determine 5 dimensions of fatigue: general fatigue, physical fatigue, reduced motivation, reduced activity, and mental fatigue. We also reported the total fatigue score as the sum of all subcomponents.
We used the normative data from Schwarz et al [42] and Hinz et al [44] to choose thresholds for each subcomponent.
J Med Internet Res 2024;26:e58572
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Connolly et al [8] found that patients often report fatigue as one of the most debilitating symptoms, significantly impacting daily functioning and quality of life. They report that fatigue occurs across a range of chronic diseases, including multiple sclerosis (MS) and cancer. A recent meta-analysis evaluated the prevalence of severe and chronic fatigue in a cohort of individuals with chronic diseases, finding that 23% experienced severe fatigue and 17% suffered from chronic fatigue [11].
JMIR Serious Games 2024;12:e55034
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Fatigue was the most persistent symptom, with a prevalence among hospitalized, nonhospitalized, and mixed-patient cohorts of 28.4%, 34.8%, and 25.2%, respectively [12]. Fatigue could be due to the excessive respiratory efforts related to the respiratory complications of a SARS-Co V-2 infection [13]. However, the lack of a gold-standard scale for assessing fatigue, as well as the subjective nature of this symptom, makes it a poorly evaluated condition.
JMIR Public Health Surveill 2024;10:e47465
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Supportive care interventions to prevent and manage the adverse psychological and physical effects of cancer across the cancer trajectory effectively improve outcomes such as emotional distress, Qo L, and fatigue [6]. Optimal supportive care is holistic and patient centered, that is, based on the needs of each individual patient [7].
J Med Internet Res 2024;26:e51949
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In addition to dryness, common extraglandular features include persistent fatigue [13], chronic pain [14], sleep disturbances [15], and anxiety and depression [16]. People with SS report experiencing these symptoms as being interconnected, with the exacerbation of one symptom impacting others [17-19].
Similar to many other autoimmune diseases, SS does not have a cure [20].
JMIR Hum Factors 2024;11:e54172
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Fatigue is recognized as one of the most common symptoms in individuals with chronic postviral conditions. It is defined as the early onset of tiredness after starting an activity, a feeling of exhaustion or difficulty in carrying out a physical (physical fatigue) or cognitive (cognitive fatigue) task, which is not recovered after a rest [1]. It is relevant to highlight several issues included in this definition.
JMIR Res Protoc 2024;13:e50157
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