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Evaluation of the Tu’Washindi Na PrEP Intervention to Reduce Gender-Based Violence and Increase Preexposure Prophylaxis Uptake and Adherence Among Kenyan Adolescent Girls and Young Women: Protocol for a Cluster Randomized Controlled Trial

In western Kenya, a study of adolescent girls and young women attending family planning clinics found that 76% met Pr EP eligibility criteria, but only 4% initiated Pr EP [16], and the proportion of adolescent girls and young women persisting with Pr EP for 3 months postinitiation ranged from 5% to 37% across studies [7,10,11,15,17]. In samples of Pr EP users at an average of 6 months postinitiation, only 4% to 8% had tenofovir diphosphate (TFVdp) levels suggesting high adherence [4-6].

Sarah T Roberts, Alexandra M Minnis, Sue Napierala, Elizabeth T Montgomery, Lina Digolo, Mackenzie L Cottrell, Erica N Browne, Jacqueline Ndirangu, Joyce Boke, Kawango Agot

JMIR Res Protoc 2025;14:e55931

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Dissemination and Implementation Approach to Increasing Access to Local Pre-Exposure Prophylaxis (PrEP) Resources With Black Cisgender Women: Intervention Study With Vlogs Shared on Social Media

Lastly, the feasibility measure will indicate how well vlogs can be used to motivate access to Pr EP.

Mandy J Hill, Laurenia Mangum, Sandra J Coker, Tristen Sutton, Diane M Santa Maria

JMIR Public Health Surveill 2025;11:e67367

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Developing and Implementing Provider-Training and Evidence-Based Tools to Support Pre-exposure Prophylaxis (PrEP) Decision-Making and Increase PrEP Adherence Among Young Men Who Have Sex With Men: Protocol for the PrEP Choice Longitudinal Cohort Study

Clinical trials of sexual event-driven Pr EP regimens or 2-1-1 Pr EP using F/TDF have demonstrated it to be highly effective for HIV prevention among MSM [3,4]. These options provide MSM with choices about their preferred Pr EP regimen; however, little is known about the Pr EP choices men make, their switching between Pr EP options, and the reasons for these decisions. Pr EP coverage continues to increase markedly among men [5].

Crissi Rainer, Rebecca Schnall, Mary R Tanner, Carla A Galindo, Karen W Hoover, Sylvie Naar, Maeve Brin, Andres Martinez, Haomiao Jia, Maria Mendoza, Lisa Hightow-Weidman

JMIR Res Protoc 2025;14:e64186

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A Multicomponent Strategy to Improve HIV Pre-Exposure Prophylaxis in a Southern US Jail: Protocol for a Type 3 Hybrid Implementation-Effectiveness Trial

The Pr EP-to-need ratio, defined as the number of Pr EP users divided by new HIV diagnoses [14], is lower in the South than in any other region, particularly among racial and ethnic minorities, further highlighting inequitable access [15]. To decrease HIV incidence, there is a need to improve Pr EP use in populations most heavily impacted by HIV.

Ank E Nijhawan, Jana Kholy, Julia L Marcus, Timothy P Hogan, Robin T Higashi, Jacqueline Naeem, Laura Hansen, Brynn Torres, Barry-Lewis Harris, Song Zhang, Douglas Krakower

JMIR Res Protoc 2025;14:e64813

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Improving Pre-Exposure Prophylaxis Provision as Part of Routine Gynecologic Care Among Black Cisgender Women (Project PrEP4Her): Protocol for the Implementation of an Intervention

In addition, in 2021, Alabama had a Pr EP-to-Need ratio of 5.55, with the highest unmet need for Pr EP occurring among the Black community (Pr EP-to-need ratio among Black vs White individuals: 2.94:11.30) [9]. When focusing on cisgender women, who account for approximately one-fifth of new HIV diagnoses in the United States, only 8% of the 227,010 women with a Pr EP indication are currently receiving Pr EP prescriptions [10-13].

Maira Sohail, Lynn Matthews, Audra Williams, Mirjam-Colette Kempf, Desiree Phillips, Hannah Goymer, Bernadette Johnson,, Michael Mugavero, Latesha Elopre

JMIR Res Protoc 2025;14:e58976

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The mChoice App, an mHealth Tool for the Monitoring of Preexposure Prophylaxis Adherence and Sexual Behaviors in Young Men Who Have Sex With Men: Usability Evaluation

Preexposure prophylaxis (Pr EP) is a highly effective biomedical prevention strategy to reduce HIV incidence and curb the HIV epidemic [3-10]. When taken as prescribed (daily or at least 4 times per week), Pr EP reduces HIV transmission by up to 99% among MSM [7-9,11-13].

Fabiana Cristina Dos Santos, Maeve Brin, Mary R Tanner, Carla A Galindo, Rebecca Schnall

JMIR Hum Factors 2025;12:e59780

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Adolescent Youth Survey on HIV Prevention and Sexual Health Education in Alabama: Protocol for a Web-Based Survey With Fraud Protection Study

In 2019, pre-exposure prophylaxis (Pr EP) was established as safe and effective in preventing HIV among adolescent-aged men who have sex with men (MSM), and the US Food and Drug Administration approved Pr EP for individuals weighing at least 77 pounds (~34.9 kg), thereby making it available to adolescents [10,11]. Nevertheless, prescribing Pr EP to adolescents remains under ideal levels [12].

Henna Budhwani, Ibrahim Yigit, Josh Bruce, Christyenne Lily Bond, Andrea Johnson

JMIR Res Protoc 2025;14:e63114

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Sexual and Gender Minority Adolescents’ Preferences for HIV Pre-Exposure Prophylaxis Social Marketing Campaigns: Qualitative Preimplementation Study

Despite the US Food and Drug Administration’s approval of oral Pr EP for individuals aged under 18 years in 2018 and long-acting injectable Pr EP in 2021 [7], Pr EP uptake remains subpar in this age group [8,9]. One study that used US pharmacy claims data to estimate adolescent Pr EP use [10] found that of the 6444 youths aged 13 to 19 years who were prescribed Pr EP in 2021, just 12% were aged under 18 years, and most were adolescent girls.

Kathryn Macapagal, Juan Pablo Zapata, Junye Ma, Jacob D Gordon, Christopher Owens, Silvia Valadez-Tapia, Peter Cummings, Nathan Walter, Jim Pickett

JMIR Form Res 2025;9:e60398

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Awareness of Sexual Partner’s HIV Status Among Men Who Have Sex With Men in China: Cross-Sec. tional Survey Study

MSM who were aware of HIV Pr EP and PEP were more likely to obtain their sexual partners’ HIV status. A previous study showed that awareness of and access to Pr EP might reduce the need and motivation to discuss HIV status with partners because they may assume that it is the partner’s responsibility to use Pr EP to protect themselves from HIV infection [13].

Qian Ma, Tingting Jiang, Wanjun Chen, Shaoqiang Jiang, Jinlei Zheng, Hui Wang, Lin He

JMIR Public Health Surveill 2025;11:e66139

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Studying the Digital Intervention Engagement–Mediated Relationship Between Intrapersonal Measures and Pre-Exposure Prophylaxis Adherence in Sexual and Gender Minority Youth: Secondary Analysis of a Randomized Controlled Trial

active Pr EP prescription (prescription confirmed by study staff) or those who were currently on Pr EP who had an active Pr EP prescription (prescription confirmed by study staff).

Michael P Williams, Justin Manjourides, Louisa H Smith, Crissi B Rainer, Lisa B Hightow-Weidman, Danielle F Haley

J Med Internet Res 2025;27:e57619

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Search Results (1 to 10 of 71 Results)