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This study aims to outline the design, implementation, and deployment of a modular data transformation pipeline that transforms oncological RWD into an HL7 FHIR format and then into a tabular format in preparation for a federated analysis (FA) across the 6 BZKF university hospitals.
J Med Internet Res 2025;27:e65681
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The creation of a trauma-informed codevelopment space was crucial to facilitate safer and more open discussions. To accomplish this, we established a parallel, intervention refinement process using a helical structure developed by this team and based on our prior research with structural indicators for community-based participatory action research [33]. As shown in Figure 2, the “hand off” of work drives an iterative (helical) thinking process.
JMIR Res Protoc 2025;14:e69829
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The index visit was defined as the first order of a culprit medication for a given patient on a given hospitalization (encounter), with only one medication used to define each hospitalization for each patient. As such, a given individual patient could be included more than once, although each encounter (hospitalization) was only used once for each patient under a given culprit medication. The earliest date of enrollment was July 6, 2011, and the latest was April 16, 2024.
J Med Internet Res 2025;27:e68256
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The International Organization for Standardization describes usability as “the extent to which a system, product or service can be used by specified users to achieve specified goals with effectiveness, efficiency and satisfaction in a specified context of use” [1]. Usability testing is a method in which a product is evaluated by users as they perform tasks, and may include formative or summative testing [2].
JMIR Res Protoc 2025;14:e64350
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To enhance recruitment, a home testing option is provided, allowing families to conveniently perform finger-prick testing and data collection at home.
After screening results are available, a research physician reviews the findings. Participants who test positive for islet autoantibodies are invited to a follow-up visit that includes personalized counseling, targeted educational interventions, and additional metabolic staging to determine their T1 D stage.
JMIR Res Protoc 2025;14:e70575
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Conditional inference trees model the nonlinear relationships between a wide range of predictors and an outcome. As a data mining approach, the conditional inference tree is a data-driven analytic strategy that identifies interacting social determinants from many candidate predictors to determine which predictors are most relevant to specific outcomes.
J Med Internet Res 2025;27:e65452
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For example, medical students completing an online module on a basic science topic may be confident in their ability to learn but struggle to see the value in the material beyond their next examination. Conversely, students completing a virtual examination with a standardized patient may see the value in what they are learning but not feel confident in their ability to succeed.
JMIR Med Educ 2025;11:e64179
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The aim of this study is to develop risk calculators that best predict (1) a mother’s risk of having a neonate with abnormal fetal growth (large for gestational age [LGA] or small for gestational age [SGA]); (2) a mother’s risk of having a serious adverse neonatal outcome; and (3) a mother’s risk of developing new metabolic disease after pregnancy (Figure 1).
JMIR Res Protoc 2025;14:e72542
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Furthermore, this simplifies the prediction task to a single time point, making it more feasible to compare multiple models and augmentation strategies. Patients with a chest radiograph within 48 hours before the first elevated e CART score were included in the study. Available anterior-posterior or posterior-anterior views were included in the study cohort.
JMIR AI 2025;4:e67144
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Transcripts were coded by the first author following a template analysis approach [18] with NVivo software (version 14; Lumivero), using a prespecified codebook. The codebook was created according to a hybrid approach, using a deductive approach to generate high-level codes based on the CFIR Codebook Template [15], and an inductive approach to incorporate themes that arose from the data [19].
JMIR Form Res 2025;9:e67624
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