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Methadone Patient Access to Collaborative Treatment: Protocol for a Pilot and a Randomized Controlled Trial to Establish Feasibility of Adoption and Impact on Methadone Treatment Delivery and Patient Outcomes

Methadone Patient Access to Collaborative Treatment: Protocol for a Pilot and a Randomized Controlled Trial to Establish Feasibility of Adoption and Impact on Methadone Treatment Delivery and Patient Outcomes

The creation of a trauma-informed codevelopment space was crucial to facilitate safer and more open discussions. To accomplish this, we established a parallel, intervention refinement process using a helical structure developed by this team and based on our prior research with structural indicators for community-based participatory action research [33]. As shown in Figure 2, the “hand off” of work drives an iterative (helical) thinking process.

Beth E Meyerson, Alissa Davis, Richard A Crosby, Linnea B Linde-Krieger, Benjamin R Brady, Gregory A Carter, Arlene N Mahoney, David Frank, Janet Rothers, Zhanette Coffee, Elana Deuble, Jonathon Ebert, Mary F Jablonsky, Marlena Juarez, Barbara Lee, Heather M Lorenz, Michael D Pava, Kristen Tinsely, Sana Yousaf

JMIR Res Protoc 2025;14:e69829

Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study

Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study

The index visit was defined as the first order of a culprit medication for a given patient on a given hospitalization (encounter), with only one medication used to define each hospitalization for each patient. As such, a given individual patient could be included more than once, although each encounter (hospitalization) was only used once for each patient under a given culprit medication. The earliest date of enrollment was July 6, 2011, and the latest was April 16, 2024.

Katy E Trinkley, Steven T Simon, Michael A Rosenberg

J Med Internet Res 2025;27:e68256

Effectiveness of The Umbrella Collaboration Versus Traditional Umbrella Reviews for Evidence Synthesis in Health Care: Protocol for a Validation Study

Effectiveness of The Umbrella Collaboration Versus Traditional Umbrella Reviews for Evidence Synthesis in Health Care: Protocol for a Validation Study

The first part of this study focuses on a quantitative comparison between the 2 tertiary synthesis methodologies. To facilitate this comparison, a targeted search in Pub Med will identify relevant TURs in geriatrics, focusing on representative reviews rather than an exhaustive search. Our approach will involve a focused search in Pub Med, using specific terms relevant to geriatrics, to find suitable TURs that serve as a benchmark for this comparative analysis.

Beltran Carrillo, Marta Rubinos-Cuadrado, Jazmin Parellada-Martin, Alejandra Palacios-López, Beltran Carrillo-Rubinos, Fernando Canillas-Del Rey, Juan Jose Baztán-Cortes, Javier Gómez-Pavon

JMIR Res Protoc 2025;14:e67248

Designing eHealth Interventions for Pediatric Emergency Departments: Protocol for a Usability Testing Study With Youth, Parent, and Clinician Participants

Designing eHealth Interventions for Pediatric Emergency Departments: Protocol for a Usability Testing Study With Youth, Parent, and Clinician Participants

The International Organization for Standardization describes usability as “the extent to which a system, product or service can be used by specified users to achieve specified goals with effectiveness, efficiency and satisfaction in a specified context of use” [1]. Usability testing is a method in which a product is evaluated by users as they perform tasks, and may include formative or summative testing [2].

Mari Somerville, Lori Wozney, Allyson Gallant, Janet A Curran

JMIR Res Protoc 2025;14:e64350

Early Detection of Type 1 Diabetes in First-Degree Relatives in Saudi Arabia (VISION-T1D): Protocol for a Pilot Implementation Study

Early Detection of Type 1 Diabetes in First-Degree Relatives in Saudi Arabia (VISION-T1D): Protocol for a Pilot Implementation Study

To enhance recruitment, a home testing option is provided, allowing families to conveniently perform finger-prick testing and data collection at home. After screening results are available, a research physician reviews the findings. Participants who test positive for islet autoantibodies are invited to a follow-up visit that includes personalized counseling, targeted educational interventions, and additional metabolic staging to determine their T1 D stage.

Iman S Algadi, Yazed AlRuthia, Muhammad H Mujammami, Khaled Hani Aburisheh, Metib Alotaibi, Sharifah Al Issa, Amal A Al-Saif, David Seftel, Cheng-Ting Tsai, Reem A Al Khalifah

JMIR Res Protoc 2025;14:e70575

Identifying Intersecting Factors Associated With Suicidal Thoughts and Behaviors Among Transgender and Gender Diverse Adults: Preliminary Conditional Inference Tree Analysis

Identifying Intersecting Factors Associated With Suicidal Thoughts and Behaviors Among Transgender and Gender Diverse Adults: Preliminary Conditional Inference Tree Analysis

Conditional inference trees model the nonlinear relationships between a wide range of predictors and an outcome. As a data mining approach, the conditional inference tree is a data-driven analytic strategy that identifies interacting social determinants from many candidate predictors to determine which predictors are most relevant to specific outcomes.

Amelia M Stanton, Lauren A Trichtinger, Norik Kirakosian, Simon M Li, Katherine E Kabel, Kiyan Irani, Alexandra H Bettis, Conall O’Cleirigh, Richard T Liu, Qimin Liu

J Med Internet Res 2025;27:e65452

Motivation Theories and Constructs in Experimental Studies of Online Instruction: Systematic Review and Directed Content Analysis

Motivation Theories and Constructs in Experimental Studies of Online Instruction: Systematic Review and Directed Content Analysis

For example, medical students completing an online module on a basic science topic may be confident in their ability to learn but struggle to see the value in the material beyond their next examination. Conversely, students completing a virtual examination with a standardized patient may see the value in what they are learning but not feel confident in their ability to succeed.

Adam Gavarkovs, Erin Miller, Jaimie Coleman, Tharsiga Gunasegaran, Rashmi A Kusurkar, Kulamakan Kulasegaram, Melanie Anderson, Ryan Brydges

JMIR Med Educ 2025;11:e64179

Impact of Disclosing to Patients the Use of Antiretroviral Resistance Testing Results for Molecular HIV Surveillance: A Randomized Experiment in 2 National Surveys

Impact of Disclosing to Patients the Use of Antiretroviral Resistance Testing Results for Molecular HIV Surveillance: A Randomized Experiment in 2 National Surveys

To this end, our multidisciplinary team is conducting a mixed-methods, multiphase research project titled, “Study of Ethics and Stakeholder Attitudes towards Molecular Epidemiology (SESAME)” to collect data from a wide range of stakeholders to inform developing policies and practices.

Jeremy Sugarman, Juli Bollinger, Jose Agostini, Kevin Weinfurt, Gail Geller, Sheethal Jose, Marissa Hannah, O. Winslow Edwards, Leslie Meltzer Henry, Travis Sanchez

JMIR Public Health Surveill 2025;11:e64663

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

The aim of this study is to develop risk calculators that best predict (1) a mother’s risk of having a neonate with abnormal fetal growth (large for gestational age [LGA] or small for gestational age [SGA]); (2) a mother’s risk of having a serious adverse neonatal outcome; and (3) a mother’s risk of developing new metabolic disease after pregnancy (Figure 1).

Sarah A L Price, Digsu N Koye, Alice Lewin, Alison Nankervis, Stefan C Kane

JMIR Res Protoc 2025;14:e72542