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Optimizing Initial Vancomycin Dosing in Hospitalized Patients Using Machine Learning Approach for Enhanced Therapeutic Outcomes: Algorithm Development and Validation Study

Optimizing Initial Vancomycin Dosing in Hospitalized Patients Using Machine Learning Approach for Enhanced Therapeutic Outcomes: Algorithm Development and Validation Study

In a study by Yoon et al [12], 69.8% (2051/2570) of cases had initial vancomycin trough concentrations outside the therapeutic range (10-20 mg/L). According to the latest clinical guidelines on TDM for vancomycin, the recommended dosage for serious MRSA infections is 15-20 mg/kg every 8-12 hours [6]. While the vancomycin package insert provides renal function-based dosing guidelines, in real-world clinical practice, initial doses are often determined based on the clinician’s experience [13,14].

Heonyi Lee, Yi-Jun Kim, Jin-Hong Kim, Soo-Kyung Kim, Tae-Dong Jeong

J Med Internet Res 2025;27:e63983

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