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Virtual Patients Using Large Language Models: Scalable, Contextualized Simulation of Clinician-Patient Dialogue With Feedback

Virtual Patients Using Large Language Models: Scalable, Contextualized Simulation of Clinician-Patient Dialogue With Feedback

Response options for all items ranged from 1=strongly disagree to 6=strongly agree. b GPT: generative pretrained transformer. c This contrast was selected for reporting post hoc, after the omnibus test across all human clinician personas revealed statistically significant differences (P≤.03) for all outcomes except feedback.

David A Cook, Joshua Overgaard, V Shane Pankratz, Guilherme Del Fiol, Chris A Aakre

J Med Internet Res 2025;27:e68486

Assessing the Noninferiority of a Rhythm and Language Training Serious Game Combined With Speech Therapy Versus Speech Therapy Care for Children With Dyslexia: Protocol for an Investigator-Blinded Randomized Controlled Trial

Assessing the Noninferiority of a Rhythm and Language Training Serious Game Combined With Speech Therapy Versus Speech Therapy Care for Children With Dyslexia: Protocol for an Investigator-Blinded Randomized Controlled Trial

Other criteria include fluency in French or bilingualism in French at home, at least 3 years of schooling in France, and access to a tablet or smartphone at home. In addition, participants must be affiliated with the French National Insurance system, and both the child and their legal guardians must provide informed consent and agree to follow the study protocol. Only one child per family will be enrolled.

Charline Grossard, Mélanie Descamps, Sara Cadoni, Hugues Pellerin, François Vonthron, Jean Xavier, Bruno Falissard, David Cohen

JMIR Res Protoc 2025;14:e71326

Comparison of Smart Display Versus Laptop Platforms for an eHealth Intervention to Improve Functional Health for Older Adults With Multiple Chronic Conditions: Protocol for a Randomized Clinical Trial

Comparison of Smart Display Versus Laptop Platforms for an eHealth Intervention to Improve Functional Health for Older Adults With Multiple Chronic Conditions: Protocol for a Randomized Clinical Trial

Results indicated that 282 participants after attrition would be needed for 80% power (P With regard to power for moderation analyses, we ran a sensitivity analysis to compute the smallest effect size our study would be powered to find using 280 given 4 groups (eg, 2 study arms × 2 genders). With N=280, G*Power calculations [63] show our study would have a 95% chance (with P Patients will complete surveys at baseline, 6, 12, and 18 months.

David H Gustafson Sr, Marie-Louise Mares, Darcie C Johnston, John J Curtin, Klaren Pe-Romashko, Gina Landucci

JMIR Res Protoc 2025;14:e64449

Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial

Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial

Studies have repeatedly noted that delay and deficiency in diagnosis disproportionately impacts individuals from historically minoritized racial and ethnic groups as well as those from socioeconomically disadvantaged backgrounds [3-12]; for example, a recent nationally representative study found that a higher proportion of non-Hispanic Black and Hispanic individuals had a missed or delayed clinical dementia diagnosis compared to non-Hispanic White individuals (46% and 54% vs 41%; P Experts recommend robust,

Rachel Beth Rosansky Chalmer, Emmeline Ayers, Erica F Weiss, Nicole R Fowler, Andrew Telzak, Diana Summanwar, Jessica Zwerling, Cuiling Wang, Huiping Xu, Richard J Holden, Kevin Fiori, Dustin D French, Celeste Nsubayi, Asif Ansari, Paul Dexter, Anna Higbie, Pratibha Yadav, James M Walker, Harrshavasan Congivaram, Dristi Adhikari, Mairim Melecio-Vazquez, Malaz Boustani, Joe Verghese

JMIR Res Protoc 2025;14:e60471

A Remote Intervention Based on mHealth and Community Health Workers for Antiretroviral Therapy Adherence in People With HIV: Pilot Randomized Controlled Trial

A Remote Intervention Based on mHealth and Community Health Workers for Antiretroviral Therapy Adherence in People With HIV: Pilot Randomized Controlled Trial

No significant differences were observed between the groups at baseline (P=.81) or follow-up (P=.64), and no significant within-group changes were observed over time (control: P=.52 and intervention: P=.07; Figure 5). The overall scale had excellent internal consistency, with Cronbach α=0.95 at baseline and Cronbach α=0.98 at follow-up [52].

Shivesh Shourya, Jianfang Liu, Sophia McInerney, Trinity Casimir, James Kenniff, Trace Kershaw, David Batey, Rebecca Schnall

JMIR Form Res 2025;9:e67997

Innovating Care for Postmenopausal Women Using a Digital Approach for Pelvic Floor Dysfunctions: Prospective Longitudinal Cohort Study

Innovating Care for Postmenopausal Women Using a Digital Approach for Pelvic Floor Dysfunctions: Prospective Longitudinal Cohort Study

Statistical significance was defined as P Of the 3684 participants screened for eligibility, 633 participants were excluded (346 declined participation and 287 did not meet eligibility criteria; Figure 2). The program started with 3051 participants, of which 2367 participants completed it, translating into a completion rate of 77.6%. Study flowchart.

Ana P Pereira, Dora Janela, Anabela C Areias, Maria Molinos, Xin Tong, Virgílio Bento, Vijay Yanamadala, Jennesa Atherton, Fernando Dias Correia, Fabíola Costa

JMIR Mhealth Uhealth 2025;13:e68242

Digital Ergonomics of NavegApp, a Novel Serious Game for Spatial Cognition Assessment: Content Validity and Usability Study

Digital Ergonomics of NavegApp, a Novel Serious Game for Spatial Cognition Assessment: Content Validity and Usability Study

Analysis using Cramér V indicated a moderate association between the perception of agreeableness and difficulty for each task (χ24=16.5; P=.002; V=0.37, 95% CI 0.28-0.54). Further examination of the frequency distribution indicated that as tasks were perceived as more difficult, participants found them less agreeable. Figure 4 displays the difficulty (Figure 4 A) and agreeableness (Figure 4 B) perception by task. Agreeableness and difficulty perception by task.

Juan Pablo Sanchez-Escudero, David Aguillon, Stella Valencia, Mauricio A Garcia-Barrera, Daniel Camilo Aguirre-Acevedo, Natalia Trujillo

JMIR Serious Games 2025;13:e66167

Escape Game to Promote Students’ Mental Health Outcomes in the Aftermaths of COVID-19 Pandemic: Protocol for a Mixed Methods Study Evaluating a Cocreated Intervention

Escape Game to Promote Students’ Mental Health Outcomes in the Aftermaths of COVID-19 Pandemic: Protocol for a Mixed Methods Study Evaluating a Cocreated Intervention

Inclusion criteria are (1) being a student at the University of Bordeaux, (2) being aged ≥18 years, (3) understanding, speaking, and writing French, and (4) having given the electronic consent to be enrolled in the study. We consider that students have a sufficient level of computer literacy for playing the game as only few basic skills are required: knowing how to navigate the web, keyboarding, and typing.

David Labrosse, Clara Vié, Mireille Harb, Ilaria Montagni

JMIR Res Protoc 2025;14:e64068

Assessment of Community Stakeholders’ and Health Educators and Professionals’ Needs for the Continuous Enhancement of Sexual and Reproductive Health and Rights in Mali (Project CLEFS): Protocol for a Convergent Mixed Methods Study

Assessment of Community Stakeholders’ and Health Educators and Professionals’ Needs for the Continuous Enhancement of Sexual and Reproductive Health and Rights in Mali (Project CLEFS): Protocol for a Convergent Mixed Methods Study

To address these concerns, the Canadian consortium—which is composed of Santé Monde, the Cégep de Saint Jérôme and the Centre interdisciplinaire de développement international en santé from University of Sherbrooke and funded by Global Affairs Canada—has implemented the Local Teaching Communities for Healthy Women and Girls (Communautés locales d’enseignement pour les femmes et les filles en santé [CLEFS; French]) project.

Sabina Abou Malham, Doufain Traoré, Fatoumata Dicko, Gabriel Blouin Genest, Jennyfer Boudreau, Drissa Mansa Sidibé, Souleymane Sidibé, Issa Souleymane Goïta, Aminata Sangaré, Mohamed Togo, Delphine Diarra, Michèle Rietmann, Mahamane Mahamoudou Maïga, Suzie Boulanger, Ann Isabelle Grégoire, David-Martin Milot, Djamal Berbiche, Sarah Stecko

JMIR Res Protoc 2025;14:e64796