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Assessing the Noninferiority of a Rhythm and Language Training Serious Game Combined With Speech Therapy Versus Speech Therapy Care for Children With Dyslexia: Protocol for an Investigator-Blinded Randomized Controlled Trial

Assessing the Noninferiority of a Rhythm and Language Training Serious Game Combined With Speech Therapy Versus Speech Therapy Care for Children With Dyslexia: Protocol for an Investigator-Blinded Randomized Controlled Trial

It is crucial to evaluate the impact of a technology compared with its cost [27]. In addition, the impact of a new treatment must also take into account other variables such as treatment adherence or safety. To assess these points, a number of trials use a noninferiority paradigm [28,29]. The objective of these trials is to evaluate if a new treatment can be considered not worse than the gold-standard treatment by an acceptably small amount, with a given degree of confidence [30].

Charline Grossard, Mélanie Descamps, Sara Cadoni, Hugues Pellerin, François Vonthron, Jean Xavier, Bruno Falissard, David Cohen

JMIR Res Protoc 2025;14:e71326

Comparison of Smart Display Versus Laptop Platforms for an eHealth Intervention to Improve Functional Health for Older Adults With Multiple Chronic Conditions: Protocol for a Randomized Clinical Trial

Comparison of Smart Display Versus Laptop Platforms for an eHealth Intervention to Improve Functional Health for Older Adults With Multiple Chronic Conditions: Protocol for a Randomized Clinical Trial

Developed by our Agency for Healthcare Research and Quality Center of Excellence in Active Aging, it was first tested in a randomized controlled trial (RCT) involving a community sample of 390 participants age 65+ years who received a laptop either with or without Elder Tree access for 12 months [28].

David H Gustafson Sr, Marie-Louise Mares, Darcie C Johnston, John J Curtin, Klaren Pe-Romashko, Gina Landucci

JMIR Res Protoc 2025;14:e64449

A Remote Intervention Based on mHealth and Community Health Workers for Antiretroviral Therapy Adherence in People With HIV: Pilot Randomized Controlled Trial

A Remote Intervention Based on mHealth and Community Health Workers for Antiretroviral Therapy Adherence in People With HIV: Pilot Randomized Controlled Trial

Figure 2 A shows the Clever Cap and its packaging, which includes a micro-USB charger. Figure 2 B demonstrates Clever Cap’s built-in reminder system, which provided a visual and auditory alarm when it was time to take a scheduled dose. The bottle flashed green lights for 2 minutes and emitted a loud alarm to ensure that the reminder was noticeable. These cues automatically ceased once the cap was unscrewed, signaling a recorded dose.

Shivesh Shourya, Jianfang Liu, Sophia McInerney, Trinity Casimir, James Kenniff, Trace Kershaw, David Batey, Rebecca Schnall

JMIR Form Res 2025;9:e67997

Identifying Patient-Reported Outcome Measure Documentation in Veterans Health Administration Chiropractic Clinic Notes: Natural Language Processing Analysis

Identifying Patient-Reported Outcome Measure Documentation in Veterans Health Administration Chiropractic Clinic Notes: Natural Language Processing Analysis

Multiple notes can be written to describe the same identified chiropractic visit; for example, a resident chiropractor note and an attending chiropractor note may each contain data relevant to a single visit. We concatenated all notes linked to the same unique visit identifier on the same date of service (regardless of note author) to create a 1-to-1 relationship between visits and clinic notes. A unique character set was used as a delimiter to separate individual notes.

Brian C Coleman, Kelsey L Corcoran, Cynthia A Brandt, Joseph L Goulet, Stephen L Luther, Anthony J Lisi

JMIR Med Inform 2025;13:e66466

Digital Ergonomics of NavegApp, a Novel Serious Game for Spatial Cognition Assessment: Content Validity and Usability Study

Digital Ergonomics of NavegApp, a Novel Serious Game for Spatial Cognition Assessment: Content Validity and Usability Study

SC involves a range of cognitive functions, including the perception, organization, and use of location and object–based information to understand and navigate through physical or mental spaces [12-14]. When integrated, these processes facilitate complex spatial behaviors, such as solving mazes or tracing routes from point A to point B using landmarks or self-positioning as a reference [13].

Juan Pablo Sanchez-Escudero, David Aguillon, Stella Valencia, Mauricio A Garcia-Barrera, Daniel Camilo Aguirre-Acevedo, Natalia Trujillo

JMIR Serious Games 2025;13:e66167

Escape Game to Promote Students’ Mental Health Outcomes in the Aftermaths of COVID-19 Pandemic: Protocol for a Mixed Methods Study Evaluating a Cocreated Intervention

Escape Game to Promote Students’ Mental Health Outcomes in the Aftermaths of COVID-19 Pandemic: Protocol for a Mixed Methods Study Evaluating a Cocreated Intervention

Thomas is a university student and we follow him during a typical day in lockdown. To move from one room to another, players must solve all the puzzles by clicking on the objects spread out in Thomas’ room. At the end of each room scenario, a set of cards is shown, with each card containing a mental health-related message. The cards synthesize the messages transmitted through the puzzles in the room.

David Labrosse, Clara Vié, Mireille Harb, Ilaria Montagni

JMIR Res Protoc 2025;14:e64068

Assessment of Community Stakeholders’ and Health Educators and Professionals’ Needs for the Continuous Enhancement of Sexual and Reproductive Health and Rights in Mali (Project CLEFS): Protocol for a Convergent Mixed Methods Study

Assessment of Community Stakeholders’ and Health Educators and Professionals’ Needs for the Continuous Enhancement of Sexual and Reproductive Health and Rights in Mali (Project CLEFS): Protocol for a Convergent Mixed Methods Study

There is a significantly higher fertility rate (6.8 vs 4.9 in urban areas), a lower proportion of prenatal care visits (37% vs 67% in urban areas), a higher proportion of deliveries outside a health facility (39% vs 7% in urban areas), as well as more limited access to FP (contraceptive prevalence rate for sexually active women not in a union is of 27% vs 44% in urban areas) [3].

Sabina Abou Malham, Doufain Traoré, Fatoumata Dicko, Gabriel Blouin Genest, Jennyfer Boudreau, Drissa Mansa Sidibé, Souleymane Sidibé, Issa Souleymane Goïta, Aminata Sangaré, Mohamed Togo, Delphine Diarra, Michèle Rietmann, Mahamane Mahamoudou Maïga, Suzie Boulanger, Ann Isabelle Grégoire, David-Martin Milot, Djamal Berbiche, Sarah Stecko

JMIR Res Protoc 2025;14:e64796

Digital Health Resilience and Well-Being Interventions for Military Members, Veterans, and Public Safety Personnel: Environmental Scan and Quality Review

Digital Health Resilience and Well-Being Interventions for Military Members, Veterans, and Public Safety Personnel: Environmental Scan and Quality Review

Each DMHI was evaluated based on 2 quality rating scales: the A-MARS and the ARIA. A description of each is provided in the subsequent sections. The A-MARS [33] is a rating scale adapted from the MARS [34] and was used to review RBs and WBPs. The A-MARS was developed to evaluate health-related e-tools, with a specific expansion of the engagement subscale.

Rashell R Allen, Myrah A Malik, Carley Aquin, Lucijana Herceg, Suzette Brémault-Phillips, Phillip R Sevigny

JMIR Mhealth Uhealth 2025;13:e64098

Impact of Digital Engagement on Weight Loss Outcomes in Obesity Management Among Individuals Using GLP-1 and Dual GLP-1/GIP Receptor Agonist Therapy: Retrospective Cohort Service Evaluation Study

Impact of Digital Engagement on Weight Loss Outcomes in Obesity Management Among Individuals Using GLP-1 and Dual GLP-1/GIP Receptor Agonist Therapy: Retrospective Cohort Service Evaluation Study

The selection of a 5-month follow-up duration was based on data availability, representing a cross-sectional cohort of individuals who were recently onboarded to the platform for the weight loss service, allowing for a consistent assessment of early treatment outcomes across all participants in the initial 5 months where significant weight loss is typically observed [9].

Hans Johnson, David Huang, Vivian Liu, Mahmoud Al Ammouri, Christopher Jacobs, Austen El-Osta

J Med Internet Res 2025;27:e69466