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Currently submitted to: JMIR Public Health and Surveillance

Date Submitted: Nov 7, 2020
(currently open for review)

Warning: This is an author submission that is not peer-reviewed or edited. Preprints - unless they show as "accepted" - should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.

The occurrence of cardiovascular complications associated with SARS-CoV-2 infection: a systematic review

  • Daniele Sardinha; 
  • Karla Valéria Batista Lima; 
  • Thalyta Mariany Rêgo Lopes Ueno; 
  • Yan Corrêa Rodrigues; 
  • Juliana Conceição Dias Garcez; 
  • Anderson Lineu Siqueira Dos Santos; 
  • Ana Lúcia Da Silva Ferreira; 
  • Ricardo José De Paula Souza E Guimarães; 
  • Luana Nepomuceno Gondim Costa Lima


The Cardiovascular Diseases represent the main cause of death in the world, and are associated as risk factors that cause serious complications in cases of infections, such as those of the respiratory tract. In March 2020 the World Health Organization declared a pandemic for SARS-CoV-2, a new coronavirus causing severe pneumonia, which emerged in December 2019 in Wuhan, China. The objective is to investigate the occurrence of cardiovascular complications associated with SARS-CoV-2 infection. It is a systematic review, quantitative, in the databases, PubMed and Science direct, including primary studies with hospitalized patients confirmed for COVID-19 and who presented cardiovascular complications, form used tools for evaluation of quality and evidence, following the PRISMA recommendations.


12 studies were included. The occurrence of cardiovascular complications was: 27.35% of the sample of 3,316 patients. Types: Acute cardiac injury 17.09%; Thromboembolism 4.73%; Heart failure 3.43%; Arrhythmias 1.77%; Brain stroke 0.33%. Mean age 61 years.


This study showed that there are several cardiovascular complications associated with SARS-CoV-2, that the main one is acute cardiac injury, which causes several instabilities in the cardiopulmonary system, and that it is associated with mortality.


Please cite as:

Sardinha D, Lima KVB, Ueno TMRL, Rodrigues YC, Garcez JCD, Santos ALSD, Ferreira ALDS, Guimarães RJDPSE, Lima LNGC

The occurrence of cardiovascular complications associated with SARS-CoV-2 infection: a systematic review

JMIR Preprints. 07/11/2020:25587


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