TY - JOUR AU - Fearon, Elizabeth AU - Chabata, Sungai T AU - Thompson, Jennifer A AU - Cowan, Frances M AU - Hargreaves, James R PY - 2017 DA - 2017/09/14 TI - Sample Size Calculations for Population Size Estimation Studies Using Multiplier Methods With Respondent-Driven Sampling Surveys JO - JMIR Public Health Surveill SP - e59 VL - 3 IS - 3 KW - population surveillance KW - sample size KW - sampling studies KW - surveys and questionnaires KW - research design KW - data collection KW - sex workers KW - HIV AB - Background: While guidance exists for obtaining population size estimates using multiplier methods with respondent-driven sampling surveys, we lack specific guidance for making sample size decisions. Objective: To guide the design of multiplier method population size estimation studies using respondent-driven sampling surveys to reduce the random error around the estimate obtained. Methods: The population size estimate is obtained by dividing the number of individuals receiving a service or the number of unique objects distributed (M) by the proportion of individuals in a representative survey who report receipt of the service or object (P). We have developed an approach to sample size calculation, interpreting methods to estimate the variance around estimates obtained using multiplier methods in conjunction with research into design effects and respondent-driven sampling. We describe an application to estimate the number of female sex workers in Harare, Zimbabwe. Results: There is high variance in estimates. Random error around the size estimate reflects uncertainty from M and P, particularly when the estimate of P in the respondent-driven sampling survey is low. As expected, sample size requirements are higher when the design effect of the survey is assumed to be greater. Conclusions: We suggest a method for investigating the effects of sample size on the precision of a population size estimate obtained using multipler methods and respondent-driven sampling. Uncertainty in the size estimate is high, particularly when P is small, so balancing against other potential sources of bias, we advise researchers to consider longer service attendance reference periods and to distribute more unique objects, which is likely to result in a higher estimate of P in the respondent-driven sampling survey. SN - 2369-2960 UR - http://publichealth.jmir.org/2017/3/e59/ UR - https://doi.org/10.2196/publichealth.7909 UR - http://www.ncbi.nlm.nih.gov/pubmed/28912117 DO - 10.2196/publichealth.7909 ID - info:doi/10.2196/publichealth.7909 ER -