TY  - JOUR
AU  - Lee, Hyunjun
AU  - Kim, Min Gul
AU  - Yeom, Sang Woo
AU  - Noh, Sang Jae
AU  - Jeong, Cho Yun
AU  - Kim, Min Ji
AU  - Kang, Min Gu
AU  - Ko, Ji Hoon
AU  - Park, Su Cheol
AU  - Kweon, Hyeok Tae
AU  - Sim, Sang Il
AU  - Lee, Hyun
AU  - You, Yeon Seok
AU  - Kim, Jong Seung
PY  - 2024
DA  - 2024/10/7
TI  - Association Between Ursodeoxycholic Acid and Clinical Outcomes in Patients With COVID-19 Infection: Population-Based Cohort Study
JO  - JMIR Public Health Surveill
SP  - e59274
VL  - 10
KW  - Covid 19
KW  - COVID-19
KW  - ursodeoxycholic acid
KW  - population-based cohort study
KW  - SARS-CoV-2
KW  - Coronavirus
KW  - pandemic
KW  - population-based
KW  - retrospective cohort study
KW  - propensity score
KW  - UDCA
KW  - public health
KW  - common data model
KW  - clinical
KW  - severity
AB  - Background: Several studies have investigated the relationship between ursodeoxycholic acid (UDCA) and COVID-19 infection. However, complex and conflicting results have generated confusion in the application of these results. Objective: We aimed to investigate whether the association between UDCA and COVID-19 infection can also be demonstrated through the analysis of a large-scale cohort. Methods: This retrospective study used local and nationwide cohorts, namely, the Jeonbuk National University Hospital into the Observational Medical Outcomes Partnership common data model cohort (JBUH CDM) and the Korean National Health Insurance Service claim–based database (NHIS). We investigated UDCA intake and its relationship with COVID-19 susceptibility and severity using validated propensity score matching. Results: Regarding COVID-19 susceptibility, the adjusted hazard ratio (aHR) value of the UDCA intake was significantly lowered to 0.71 in the case of the JBUH CDM (95% CI 0.52-0.98) and was significantly lowered to 0.93 (95% CI 0.90-0.96) in the case of the NHIS. Regarding COVID-19 severity, the UDCA intake was found to be significantly lowered to 0.21 (95% CI 0.09-0.46) in the case of JBUH CDM. Furthermore, the aHR value was significantly lowered to 0.77 in the case of NHIS (95% CI 0.62-0.95). Conclusions: Using a large-scale local and nationwide cohort, we confirmed that UDCA intake was significantly associated with reductions in COVID-19 susceptibility and severity. These trends remained consistent regardless of the UDCA dosage. This suggests the potential of UDCA as a preventive and therapeutic agent for COVID-19 infection. 
SN  - 2369-2960
UR  - https://publichealth.jmir.org/2024/1/e59274
UR  - https://doi.org/10.2196/59274
UR  - http://www.ncbi.nlm.nih.gov/pubmed/39139026
DO  - 10.2196/59274
ID  - info:doi/10.2196/59274
ER  -