%0 Journal Article %@ 2369-2960 %I JMIR Publications %V 11 %N %P e52928 %T Association Among BMI, Self-Esteem, and Nonsuicidal Self-Injury in Young Adults to Understand the Influence of Socioenvironmental Factors: Longitudinal Study %A Zhang,Yi %A Ying,Ruixue %A Lu,Wan %A Liu,Xuemeng %A Hu,Keyan %A Feng,Qing %A Yu,Zixiang %A Wang,Zhen %A Lu,Fangting %A Miao,Yahu %A Ma,Nanzhen %A Tao,Fangbiao %A Jiang,Tian %A Zhang,Qiu %K nonsuicidal self-injury %K chronotype %K BMI %K self-esteem %K body mass index %K adolescent %K young adult %K teenager %K social environmental factor %K self-injury %K sampling method %K undergraduate %K college student %K linear regression %K regression %K regression model %D 2025 %7 21.2.2025 %9 %J JMIR Public Health Surveill %G English %X Background: Nonsuicidal self-injury (NSSI) is a major public health problem leading to psychological problems in adolescents and young adults, similar to disorders such as depression and anxiety. Objective: The aims of this study were to investigate (1) the interaction between BMI and socioenvironmental factors (including chronotype and mental health) that contribute to NSSI, and (2) whether self-esteem plays a mediating role in this association. Methods: From May to June 2022, the multistage cluster sampling method was used to sample college students in four grades, including freshmen and seniors. The baseline participants were followed up 6 months later, excluding those who did not qualify, and the participants included 1772 college students. Socioenvironmental factors (chronotype/mental health), self-esteem, and NSSI were measured using a questionnaire. Multivariate linear regression models and chi-square analysis were used to evaluate the linear relationship between BMI, socioenvironmental factors, and self-esteem and the NSSI status. We use a process approach (mediation-moderation analysis) to explore the complex relationships between these variables. Results: The mean age of the participants was 20.53 (SD 1.65) years at baseline. A significant association was revealed, suggesting that a high BMI (β=.056, 95% CI 0.008‐0.086, P=.018) was associated with a higher NSSI. There was also an interaction among BMI, socioenvironmental factors, and NSSI. Socioenvironmental factors played both moderating and mediating roles in the relationship between BMI and NSSI, whereas self-esteem only played a mediating role. Conclusions: Paying attention to factors such as overweight and obesity is important for early BMI control to identify other potential risk factors for NSSI and to evaluate how self-esteem can be improved considering multiple perspectives to improve the effect of BMI on NSSI in adolescents. %R 10.2196/52928 %U https://publichealth.jmir.org/2025/1/e52928 %U https://doi.org/10.2196/52928