@Article{info:doi/10.2196/56546, author="Huang, Yiting and Feng, Shuaixin and Zhao, Yuyan and Wang, Haode and Jiang, Hongbo", title="Preferences for COVID-19 Vaccines: Systematic Literature Review of Discrete Choice Experiments", journal="JMIR Public Health Surveill", year="2024", month="Jul", day="29", volume="10", pages="e56546", keywords="systematic review; discrete choice experiment; preference; COVID-19; vaccine", abstract="Background: Vaccination can be viewed as comprising the most important defensive barriers to protect susceptible groups from infection. However, vaccine hesitancy for COVID-19 is widespread worldwide. Objective: We aimed to systematically review studies eliciting the COVID-19 vaccine preference using discrete choice experiments. Methods: A literature search was conducted in PubMed, Embase, Web of Science, Scopus, and CINAHL Plus platforms in April 2023. Search terms included discrete choice experiments, COVID-19, and vaccines and related synonyms. Descriptive statistics were used to summarize the study characteristics. Subgroup analyses were performed by factors such as high-income countries and low- and middle-income countries and study period (before, during, and after the pandemic wave). Quality appraisal was performed using the 5-item Purpose, Respondents, Explanation, Findings, and Significance checklist. Results: The search yield a total of 623 records, and 47 studies with 53 data points were finally included. Attributes were grouped into 4 categories: outcome, process, cost, and others. The vaccine effectiveness (21/53, 40{\%}) and safety (7/53, 13{\%}) were the most frequently reported and important attributes. Subgroup analyses showed that vaccine effectiveness was the most important attribute, although the preference varied by subgroups. Compared to high-income countries (3/29, 10{\%}), a higher proportion of low- and middle-income countries (4/24, 17{\%}) prioritized safety. As the pandemic progressed, the duration of protection (2/24, 8{\%}) during the pandemic wave and COVID-19 mortality risk (5/25, 20{\%}) after the pandemic wave emerged as 2 of the most important attributes. Conclusions: Our review revealed the critical role of vaccine effectiveness and safety in COVID-19 vaccine preference. However, it should be noticed that preference heterogeneity was observed across subpopulations and may change over time. Trial Registration: PROSPERO CRD42023422720; https://tinyurl.com/2etf7ny7 ", issn="2369-2960", doi="10.2196/56546", url="https://publichealth.jmir.org/2024/1/e56546", url="https://doi.org/10.2196/56546", url="http://www.ncbi.nlm.nih.gov/pubmed/39073875" }