<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Public Health Surveill</journal-id><journal-id journal-id-type="publisher-id">publichealth</journal-id><journal-id journal-id-type="index">9</journal-id><journal-title>JMIR Public Health and Surveillance</journal-title><abbrev-journal-title>JMIR Public Health Surveill</abbrev-journal-title><issn pub-type="epub">2369-2960</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v11i1e63603</article-id><article-id pub-id-type="doi">10.2196/63603</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Letter</subject></subj-group></article-categories><title-group><article-title>Net Reproduction Number as a Real-Time Metric of Population Reproducibility</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Achangwa</surname><given-names>Chiara</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Han</surname><given-names>Changhee</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Lim</surname><given-names>Jun-Sik</given-names></name><degrees>DVM, MPH</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Cho</surname><given-names>Seonghui</given-names></name><degrees>BBA</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Choi</surname><given-names>Sangbum</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Ryu</surname><given-names>Sukhyun</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><institution>Department of Preventive Medicine, College of Medicine, The Catholic University of Korea</institution><addr-line>R6117, Omibus Park, 222 Banpo-daero</addr-line><addr-line>Seoul</addr-line><country>Republic of Korea</country></aff><aff id="aff2"><institution>Computer Information System, Georgia State University</institution><addr-line>Atlanta</addr-line><addr-line>GA</addr-line><country>United States</country></aff><aff id="aff3"><institution>IHAP, Universit&#x00E9; de Toulouse, INRAE, ENVT</institution><addr-line>Toulouse</addr-line><country>France</country></aff><aff id="aff4"><institution>Department of Statistics, Korea University</institution><addr-line>Seoul</addr-line><country>Republic of Korea</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Mavragani</surname><given-names>Amaryllis</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Aktuna</surname><given-names>Atalay</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Ko</surname><given-names>Youngsuk</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Sukhyun Ryu, MD, PhD, Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, R6117, Omibus Park, 222 Banpo-daero, Seoul, 06591, Republic of Korea, 82 02-3147-8383, 82 02-532-3820; <email>gentryu@catholic.ac.kr</email></corresp></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>12</day><month>2</month><year>2025</year></pub-date><volume>11</volume><elocation-id>e63603</elocation-id><history><date date-type="received"><day>24</day><month>06</month><year>2024</year></date><date date-type="rev-recd"><day>22</day><month>11</month><year>2024</year></date><date date-type="accepted"><day>04</day><month>12</month><year>2024</year></date></history><copyright-statement>&#x00A9; Chiara Achangwa, Changhee Han, Jun-Sik Lim, Seonghui Cho, Sangbum Choi, Sukhyun Ryu. Originally published in JMIR Public Health and Surveillance (<ext-link ext-link-type="uri" xlink:href="https://publichealth.jmir.org">https://publichealth.jmir.org</ext-link>), 12.2.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Public Health and Surveillance, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://publichealth.jmir.org">https://publichealth.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://publichealth.jmir.org/2025/1/e63603"/><abstract><sec><title>Abstract</title><p>The total fertility rate (TFR) is a biased estimate of the population reproductive potential when there is a sex-ratio imbalance at birth, and it does not account for the mortality of women of childbearing age. This study aimed to estimate the reproduction rate (<inline-formula><mml:math id="ieqn1"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>), which adjusts for the sex-ratio imbalance and the mortality of women of childbearing age, and to assess the differences in the timing of when the population reached the replacement level of the TFR and <inline-formula><mml:math id="ieqn2"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>. We first estimated the <inline-formula><mml:math id="ieqn3"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> using the probability of survival in women and the number of female births. Then, using a time-series analysis, we compared the time series of the TFR and <inline-formula><mml:math id="ieqn4"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> in the Korean population between 1975 and 2022. We found the <inline-formula><mml:math id="ieqn5"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> showed a below replacement level of the population a year earlier than the TFR. However, the estimate of the time-series analysis of <inline-formula><mml:math id="ieqn6"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> was not significantly different from the estimates of the TFR. Our finding suggests that the <inline-formula><mml:math id="ieqn7"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> can provide timely information on the adjusted population reproductive potential and is easier for the public to interpret compared to TFR.</p></sec></abstract><kwd-group><kwd>fertility rate</kwd><kwd>reproducibility</kwd><kwd>reproduction rate</kwd><kwd>population control</kwd><kwd>Korea</kwd><kwd>sex ratio</kwd><kwd>imbalance</kwd><kwd>mortality</kwd><kwd>woman</kwd><kwd>female</kwd><kwd>childbearing age</kwd><kwd>reproductive age</kwd><kwd>giving birth</kwd><kwd>assessment</kwd><kwd>time series</kwd><kwd>Korean</kwd><kwd>impact analysis</kwd><kwd>birth control</kwd><kwd>reproduction</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Between 1962 and 1993, Korea implemented a successful family planning policy. In 1993, this policy was discontinued; in 2004, childbirth-promoting policies were implemented (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). In 2023, Korea had the lowest fertility rate (0.8) worldwide [<xref ref-type="bibr" rid="ref1">1</xref>]. The total fertility rate (TFR), the average offspring number per childbearing-age females (15&#x2010;49 years), is a common metric to assess population change potential. However, this cohort-based measure is biased when there is male-to-female sex-ratio imbalance at birth [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. The TFR does not account for mortality rates among childbearing-age women, possibly affecting population reproducibility [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. These limitations reduce TFR&#x2019;s ability to accurately reflect a country&#x2019;s population replacement dynamics. Therefore, the net reproduction rate (<inline-formula><mml:math id="ieqn8"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>), the number of daughters a woman of childbearing age would produce under prevailing fertility and mortality conditions, is better. Like other real-time epidemiological metrics (eg, the effective reproduction number in infectious disease modeling) [<xref ref-type="bibr" rid="ref5">5</xref>], the <inline-formula><mml:math id="ieqn9"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> can be calculated and updated regularly with new population data; it can provide timely insights into population sustainability. The <inline-formula><mml:math id="ieqn10"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> is easier for public understanding, as a population is below the replacement level when the <inline-formula><mml:math id="ieqn11"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> &#x003C; 1 [<xref ref-type="bibr" rid="ref6">6</xref>], in contrast to the TFR, with a threshold of 2.1. Despite this, no previous studies have evaluated the population reproducibility using the <inline-formula><mml:math id="ieqn12"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> in Korea.</p><p>This study assessed the differences in the timing of reaching population replacement level of the TFR and <inline-formula><mml:math id="ieqn13"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> and the estimated difference of the time series of the TFR and <inline-formula><mml:math id="ieqn14"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> by two major population control policies.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><p>We collected the annual number of live births, number of women, mortality rate of women, and male-to-female ratio of women of childbearing age between 1975 and 2022 through the Korean National Statistic Agency [<xref ref-type="bibr" rid="ref7">7</xref>] to calculate the TFR and <inline-formula><mml:math id="ieqn15"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> (<xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>). To identify the different estimates of policy impact (1975-1993: family planning policy; 1993-2004: childbirth encouragement policy), we conducted an interrupted time series (ITS) with segmented regression to examine the time trend and its level change in the TFR and <inline-formula><mml:math id="ieqn16"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>. We also conducted a cross-correlation analysis to evaluate the temporal relationship between the TFR and <inline-formula><mml:math id="ieqn17"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>. Then, we compared the estimates of <inline-formula><mml:math id="ieqn18"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> multiplied by 2.1 (TFR threshold level) with the TFR estimates along with 95% CIs. All analyses were conducted using R software (version 4.4.0; R Foundation for Statistical Computing).</p></sec><sec id="s3" sec-type="results"><title>Results</title><p>The number of live birth number decreased from 874,030 in 1975 to 249,186 in 2022. Similarly, the male-to-female sex ratio decreased from 112 in 1975 to 105 in 2022 (<xref ref-type="fig" rid="figure1">Figure 1A</xref>). The TFR remained below 2.1 since 1984 (TFR=2.04) and decreased further to 0.78 in 2022 (<xref ref-type="fig" rid="figure1">Figure 1B</xref>). The <inline-formula><mml:math id="ieqn19"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> remained below 1 since 1983 (<inline-formula><mml:math id="ieqn20"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula>=0.98) and decreased to 0.4 in 2022 (<xref ref-type="fig" rid="figure1">Figure 1C</xref>).</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>The annual number of live births, total fertility rate (TFR), and reproduction rate (R<sub>t</sub>) in South Korea, 1975-2022. (<bold>A</bold>) The bar-colored blue and sky-blue indicate the annual number of male and female births, respectively. The blue solid line indicates the yearly sex ratio of male to female births. (<bold>B</bold>) The interrupted time series model with the TFR. The interruption (dashed vertical line) was set to 1993 (when the family planning policy was discontinued) taking into account for the transition period of the policy and 2004 (when the birth encouragement policy was implemented) to identify the changes in the TFR level and slope. The horizontal dashed line indicates a critical threshold of the TFR at 2.1. The dashed orange line indicates the annual TFR based on a counterfactual scenario without changing the birth control policy, and the orange shaded area indicates 95% confidence intervaIs (CIs) of the TFR. (<bold>C</bold>) The interrupted time series model with the estimated R<sub>t</sub>; the critical threshold of R<sub>t</sub>=1. An R<sub>t</sub> &#x003C; 1 indicates that the population&#x2019;s reproductive performance falls below the replacement level. The dashed orange line indicates the annual R<sub>t</sub> based on a counterfactual scenario without changing the birth control policy, and the orange shaded area indicates 95% CIs of R<sub>t</sub>.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="publichealth_v11i1e63603_fig01.png"/></fig><p>The ITS showed an immediate increase in the mean TFR (55%) and <inline-formula><mml:math id="ieqn21"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> (26%) and an increased slope change of 9% in the TFR and 4% in <inline-formula><mml:math id="ieqn22"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> following the family planning policy discontinuation (<xref ref-type="fig" rid="figure1">Figure 1B and 1C</xref> and <xref ref-type="table" rid="table1">Table 1</xref>). After the birth encouragement policy introduction, the slope of the TFR (3%) and <inline-formula><mml:math id="ieqn23"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> (1%) increased, with no significant level change. When the <inline-formula><mml:math id="ieqn24"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> was multiplied by 2.1, the estimates were within the 95% CI of the TFR estimate (<xref ref-type="table" rid="table1">Table 1</xref>). A high correlation between the TFR and <inline-formula><mml:math id="ieqn25"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> at lag 0 indicated no temporal differences (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>).</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Estimates from the interrupted time-series analysis using the total fertility rate and reproduction rate in South Korea, 1975-2022.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom"/><td align="left" valign="bottom">Mean total fertility rate, % (95% CIs)<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup></td><td align="left" valign="bottom">Mean reproduction rate, % (95% CIs)<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup></td><td align="left" valign="bottom">Mean reproduction rate, (95% CIs) multiplied by 2.1<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td></tr></thead><tbody><tr><td align="left" valign="top">Immediate level change following the discontinuation of family planning</td><td align="left" valign="top">54.9 (33.1 to 67.2)</td><td align="left" valign="top">25.9 (18.3 to 33.8)</td><td align="left" valign="top">54.4 (38.4 to 71.0)</td></tr><tr><td align="left" valign="top">Post-intervention slope change following the discontinuation of family planning</td><td align="left" valign="top">8.9 (7.6 to 10.4)</td><td align="left" valign="top">4.2 (3.3 to 5.5)</td><td align="left" valign="top">8.8 (6.9 to 11.6)</td></tr><tr><td align="left" valign="top">Immediate level change following the birth-encouragement policy implementation</td><td align="left" valign="top">3.2 (1.3 to 4.8)</td><td align="left" valign="top">1.2 (0.1 to 2.0)</td><td align="left" valign="top">2.5 (0.2 to 4.2)</td></tr><tr><td align="left" valign="top">Post-intervention slope change following the birth-encouragement policy implementation</td><td align="left" valign="top">5.8 (-5.5 to 16.4)</td><td align="left" valign="top">3.3 (-4.6 to 11.2)</td><td align="left" valign="top">6.9 (-9.7 to 23.5)</td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>Estimates of the mean and 95% confidence intervals (CIs) from the interrupted time series with a segmented regression model to examine the time trend and its level change.</p></fn><fn id="table1fn2"><p><sup>b</sup>Estimates of the reproduction rate were multiplied by 2.1 (threshold level of total fertility rate) along with 95% CIs.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><p>The threshold level of the population replacement was captured a year earlier through the <inline-formula><mml:math id="ieqn26"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> compared to the TFR. This is likely due to sex-ratio imbalances in Korea.</p><p>The trend levels and slope changes of the TFR and <inline-formula><mml:math id="ieqn27"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> increased following the birth control policy discontinuation [<xref ref-type="bibr" rid="ref8">8</xref>]. These significant level changes were likely affected by previous birth control policies [<xref ref-type="bibr" rid="ref9">9</xref>]. However, after the child encouragement policy implementation in 2004, the TFR and <inline-formula><mml:math id="ieqn28"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> were far below the population replacement threshold, consistent with a previous study that reported no positive effect of child encouragement policies on the fertility rate [<xref ref-type="bibr" rid="ref10">10</xref>], likely due to sociocultural factors influencing fertility behavior (eg, changing gender roles and economic pressures) [<xref ref-type="bibr" rid="ref10">10</xref>]. Our study could be applied to other countries experiencing similar socioeconomic and cultural dynamics, particularly those with comparable fertility patterns and sex-ratio imbalances [<xref ref-type="bibr" rid="ref4">4</xref>].</p><p>This study had limitations. Sensitivity analyses were not included in the parameter estimation models. The ITS models were interrupted in 1993 to reflect the discontinuation of the family planning policy, accounting for the policy transition period. The ITS may not fully capture the nonlinear trends after 2015. We did not consider the qualitative characteristics of each policy.</p><p>The <inline-formula><mml:math id="ieqn29"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> can be used as a useful and timely metric of population reproducibility, particularly in the presence of sex-ratio imbalance at birth. Furthermore, the  <inline-formula><mml:math id="ieqn30"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> threshold of 1 may be easier for public interpretation compared to the TFR, as the public became familiar with the <inline-formula><mml:math id="ieqn31"><mml:msub><mml:mrow><mml:mi>R</mml:mi></mml:mrow><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:msub></mml:math></inline-formula> parameter during the COVID-19 pandemic.</p></sec></body><back><ack><p>Ethics approval was waived by the institutional review board at the Catholic University of Korea (2024-1205-0001). The authors attest that there was no use of generative artificial intelligence technology in the generation of text, figures, or other informational content in this manuscript. This work was supported by the Gorvernment-wide Research and Development to Advance Infectious Disease Prevention and Control, Republic of Korea (grant number RS-2023-KH140322), and the Basic Science Research Program through the National Research Foundation of Korea by the Ministry of Education (grant numbers NRF-2020R1I1A3066471 and 2022R1A2C1008514).</p></ack><notes><sec><title>Data Availability</title><p>The data that support the findings of this study are available on request from the corresponding author.</p></sec></notes><fn-group><fn fn-type="con"><p>SR conceived the study and designed the statistical methods. CA, CH, LSJ, and SC collected and assimilated the data. CA, CH, LSJ, and SC performed the data analysis. CA and SR wrote the first manuscript draft. CA, SC, and SR critically reviewed and edited the manuscript. All authors helped to interpret the results, critically revised the manuscript, and provided final approval of the version for publication.</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">ITS</term><def><p>interrupted time series</p></def></def-item><def-item><term id="abb2">TFR</term><def><p>total fertility rate</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="web"><article-title>World population dashboard</article-title><source>United Nations Population Fund</source><year>2023</year><publisher-name>New York, United States: UNFPA</publisher-name><comment><ext-link ext-link-type="uri" xlink:href="https://www.unfpa.org/data/world-population-dashboard">https://www.unfpa.org/data/world-population-dashboard</ext-link></comment></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation 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fertility rate and net reproduction number in South Korea (1975&#x2013;2022).</p><media xlink:href="publichealth_v11i1e63603_app3.docx" xlink:title="DOCX File, 108 KB"/></supplementary-material></app-group></back></article>