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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JPH</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Public Health Surveill</journal-id>
      <journal-title>JMIR Public Health and Surveillance</journal-title>
      <issn pub-type="epub">2369-2960</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v8i1e26868</article-id>
      <article-id pub-id-type="pmid">34479183</article-id>
      <article-id pub-id-type="doi">10.2196/26868</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>COVID-19 Mask Usage and Social Distancing in Social Media Images: Large-scale Deep Learning Analysis</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Sanchez</surname>
            <given-names>Travis</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Rovetta</surname>
            <given-names>Alessandro</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Staffini</surname>
            <given-names>Alessio</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Singh</surname>
            <given-names>Asmit Kumar</given-names>
          </name>
          <degrees>BTech</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-3313-4518</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Mehan</surname>
            <given-names>Paras</given-names>
          </name>
          <degrees>BTech</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8855-3387</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Sharma</surname>
            <given-names>Divyanshu</given-names>
          </name>
          <degrees>BE</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9457-2007</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Pandey</surname>
            <given-names>Rohan</given-names>
          </name>
          <degrees>BTech</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-6811-8054</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Sethi</surname>
            <given-names>Tavpritesh</given-names>
          </name>
          <degrees>MD, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Indraprastha Institute of Information Technology Delhi</institution>
            <addr-line>Okhla Industrial Estate, Phase III</addr-line>
            <addr-line>New Delhi, 110020</addr-line>
            <country>India</country>
            <phone>91 11 26907533</phone>
            <email>tavpriteshsethi@iiitd.ac.in</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-4776-7941</ext-link>
        </contrib>
        <contrib id="contrib6" contrib-type="author">
          <name name-style="western">
            <surname>Kumaraguru</surname>
            <given-names>Ponnurangam</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-5082-2078</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Indraprastha Institute of Information Technology Delhi</institution>
        <addr-line>New Delhi</addr-line>
        <country>India</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Netaji Subhas University of Technology</institution>
        <addr-line>New Delhi</addr-line>
        <country>India</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>Shiv Nadar University</institution>
        <addr-line>Greater Noida</addr-line>
        <country>India</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Tavpritesh Sethi <email>tavpriteshsethi@iiitd.ac.in</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>1</month>
        <year>2022</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>18</day>
        <month>1</month>
        <year>2022</year>
      </pub-date>
      <volume>8</volume>
      <issue>1</issue>
      <elocation-id>e26868</elocation-id>
      <history>
        <date date-type="received">
          <day>4</day>
          <month>1</month>
          <year>2021</year>
        </date>
        <date date-type="rev-request">
          <day>5</day>
          <month>2</month>
          <year>2021</year>
        </date>
        <date date-type="rev-recd">
          <day>6</day>
          <month>3</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>17</day>
          <month>8</month>
          <year>2021</year>
        </date>
      </history>
      <copyright-statement>©Asmit Kumar Singh, Paras Mehan, Divyanshu Sharma, Rohan Pandey, Tavpritesh Sethi, Ponnurangam Kumaraguru. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 18.01.2022.</copyright-statement>
      <copyright-year>2022</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Public Health and Surveillance, is properly cited. The complete bibliographic information, a link to the original publication on https://publichealth.jmir.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://publichealth.jmir.org/2022/1/e26868" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>The adoption of nonpharmaceutical interventions and their surveillance are critical for detecting and stopping possible transmission routes of COVID-19. A study of the effects of these interventions can help shape public health decisions. The efficacy of nonpharmaceutical interventions can be affected by public behaviors in events, such as protests. We examined mask use and mask fit in the United States, from social media images, especially during the Black Lives Matter (BLM) protests, representing the first large-scale public gatherings in the pandemic.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study assessed the use and fit of face masks and social distancing in the United States and events of large physical gatherings through public social media images from 6 cities and BLM protests.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>We collected and analyzed 2.04 million public social media images from New York City, Dallas, Seattle, New Orleans, Boston, and Minneapolis between February 1, 2020, and May 31, 2020. We evaluated correlations between online mask usage trends and COVID-19 cases. We looked for significant changes in mask use patterns and group posting around important policy decisions. For BLM protests, we analyzed 195,452 posts from New York and Minneapolis from May 25, 2020, to July 15, 2020. We looked at differences in adopting the preventive measures in the BLM protests through the mask fit score.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>The average percentage of group pictures dropped from 8.05% to 4.65% after the lockdown week. New York City, Dallas, Seattle, New Orleans, Boston, and Minneapolis observed increases of 5.0%, 7.4%, 7.4%, 6.5%, 5.6%, and 7.1%, respectively, in mask use between February 2020 and May 2020. Boston and Minneapolis observed significant increases of 3.0% and 7.4%, respectively, in mask use after the mask mandates. Differences of 6.2% and 8.3% were found in group pictures between BLM posts and non-BLM posts for New York City and Minneapolis, respectively. In contrast, the differences in the percentage of masked faces in group pictures between BLM and non-BLM posts were 29.0% and 20.1% for New York City and Minneapolis, respectively. Across protests, 35% of individuals wore a mask with a fit score greater than 80%.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>The study found a significant drop in group posting when the stay-at-home laws were applied and a significant increase in mask use for 2 of 3 cities where masks were mandated. Although a positive trend toward mask use and social distancing was observed, a high percentage of posts showed disregard for the guidelines. BLM-related posts captured the lack of seriousness to safety measures, with a high percentage of group pictures and low mask fit scores. Thus, the methodology provides a directional indication of how government policies can be indirectly monitored through social media.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>COVID-19</kwd>
        <kwd>mask detection</kwd>
        <kwd>deep learning</kwd>
        <kwd>classification</kwd>
        <kwd>segmentation</kwd>
        <kwd>social media analysis</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <p>The outbreak of COVID-19 has the world in its grips. The World Health Organization declared it as a global pandemic on March 11, 2020 [<xref ref-type="bibr" rid="ref1">1</xref>], and with exponentially rising cases, there are currently more than 32 million cases and 500,000 deaths in the United States (April 2021) [<xref ref-type="bibr" rid="ref2">2</xref>]. Following World Health Organization health advisories, most countries have declared national emergencies, closed borders, and restricted public movement [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>]. Masks have been found to reduce potential exposure risk from an infected person, proving to be a successful measure to suppress transmission and save lives [<xref ref-type="bibr" rid="ref5">5</xref>-<xref ref-type="bibr" rid="ref8">8</xref>]. Many studies have recognized the importance of community-wide use of masks for controlling the pandemic [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. Social distancing measures have also been applied to prevent sick individuals from coming into contact with healthy individuals. These social distancing and mask use measures have proven successful in many countries like China [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>]. Governments worldwide have adopted social distancing and mask use as primary nonpharmaceutical measures against the virus.</p>
      <p>With over 32 million cases and 500,000 deaths as of April 2021, the United States is one of the largest countries to be hit by the virus. In the United States, many state governments had applied several stay-at-home and mask use measures as early nonpharmaceutical interventions. In the lead up to widespread vaccine deployment, the adoption of nonpharmaceutical interventions and their surveillance are critical for detecting and stopping possible transmission routes. Quantifying the effectiveness of such measures is a challenging task, which currently relies on on-ground surveys [<xref ref-type="bibr" rid="ref13">13</xref>] or self-reported numbers [<xref ref-type="bibr" rid="ref7">7</xref>]. However, these methods are cumbersome, thus leading to lags in data and the day-to-day evolution of a fast-moving pandemic.</p>
      <p>The pervasive nature of social media provides a unique opportunity to create agile frameworks for assessing public health measures such as mask use. With its ease of access and global outreach, social media has a disproportionate influence on the dissemination of information during a pandemic [<xref ref-type="bibr" rid="ref14">14</xref>]. In recent times of the pandemic, social media has become a popular platform for people to express their thoughts and opinions, and broadcast activities. The general public and authorities have been using hashtags like #CoronaOutbreak, #COVID19, and #mask to disseminate important information and health advisories, and this provides us with an opportunity to analyze behaviors and the impact of such advisories worldwide [<xref ref-type="bibr" rid="ref15">15</xref>]. Indeed, social media has been extensively explored and analyzed for patterns that have emerged during the COVID-19 pandemic [<xref ref-type="bibr" rid="ref16">16</xref>-<xref ref-type="bibr" rid="ref19">19</xref>]. Signorini et al [<xref ref-type="bibr" rid="ref20">20</xref>] examined Twitter based-information to track the swiftly evolving public sentiment regarding Swine Flu in 2011 and correlate the H1N1 virus subtype–related activity to track reported disease levels in the United States accurately.</p>
      <p>During the pandemic, the United States also observed the Black Lives Matter (BLM) protests. The killing of George Floyd on May 25, 2020, sparked a series of protests [<xref ref-type="bibr" rid="ref21">21</xref>] and agitations across the country. Protests are designed to stimulate public action for social justice. Such protests involve the physical gathering of people, making it difficult to adhere to social distancing and to wear masks. These protests provide an opportunity to observe how people react to public health–related preventive measures during such gatherings, but collecting the necessary data from the ground is a difficult task. Such protests have also gained high popularity and attraction through online social media [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>].</p>
      <p>Realizing the potential of social media in understanding such events, in this study, we used social media images from Instagram, a popular image-sharing social media platform, which has been used by researchers to study different public health emergencies [<xref ref-type="bibr" rid="ref24">24</xref>]. Computer vision–based classifiers are necessary to check if a person is wearing a mask from an image. There exist 2 data sets previously published for mask classification tasks, namely, MAFA (Masked Faces) [<xref ref-type="bibr" rid="ref25">25</xref>] and RMFD (Real-world Masked Face Dataset) [<xref ref-type="bibr" rid="ref26">26</xref>]. The MAFA data set contains 35,805 masked images. Since the MAFA data set was curated and released in 2017, it could not capture different varieties and types of masks that have been in use during the pandemic period. The MAFA data set is biased toward 1 kind of mask; it majorly consists of medical staff wearing disposable medical-grade masks. The RMFD contains 7959 masked images with a variety of masks used during the COVID-19 period. However, a manual qualitative evaluation of the images revealed that the images were not suitable for analyzing high-quality social media images since most images were less than 50×50 resolution after cropping the face region. In addition to mask detection, analyzing the fit of the mask is a highly useful application. There is no previous work trying to analyze mask fit using semantic segmentation to the best of our knowledge.</p>
      <p>Therefore, this study fills the gap with a pipeline designed to estimate the extent of mask behaviors by assessing mask use and mask fit from 2.04 million social media images obtained from 6 US cities. Along with geographical diversity among the cities, the 6 cities also have high population numbers. These cities were also found to have a high number of location-tagged posts on Instagram and hence were chosen as the locations of interest. We demonstrate the correlation of mask use and mask fit behaviors with COVID-19 burden, policy directives, and large-scale events, such as the nationwide BLM protests, in these 6 cities.</p>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Data Sets</title>
        <p>The study was approved by the institutional review board for adherence to ethical principles of research. The images were anonymized, and aggregated statistics for states were calculated. There was no attempt to recruit subjects, reidentify subjects, or link the images with other personal information in order to maintain confidentiality. Individual-level mask use adherence was not analyzed. Anonymized images were stored on secure servers as the following 3 different data set collections:</p>
        <p>1. Mask-unmask classifier data set: This data set was used for training a model that classifies whether the person in the image is wearing a mask or not. For training, we needed images in which people were wearing masks (masked images) and images in which people were not wearing masks (unmasked images) so that our model could learn to distinguish between the 2 categories. We collected around 30,000 images of people wearing masks from Google Search images using the tags “people wearing masks” and “children wearing masks.” Images from Instagram were also collected with the tag explore feature, using the following 3 tags: “mask,” “masked,” and “covidmask.” Although the tagging algorithms used by Google are expected to capture most of the images, some images may have been missed. There is further scope for expanding our set of tags chosen to capture the entire population of images in which people are wearing masks, which is a limitation of our current approach. However, this will need more research, as capturing other scenarios may also lead to noisier sets. After data collection, images with a width and height of at least 50 pixels were kept to ensure decent image quality. Then, Face Detector was used on these images to extract faces. The images of extracted faces were distributed among 5 annotators, and the annotators were asked to classify the faces as either “masked” or “unmasked.” After the annotations, images of 9055 masked faces were obtained. For the unmasked face images, we created a random sample (without replacement) of 9055 faces from the VGGFace2 data set [<xref ref-type="bibr" rid="ref27">27</xref>], which is a large-scale face recognition data set. The samples from VGGFace2 and the mask-unmask classifier data set were used to train the unmask-mask classifier, whose details are given in the Proposed Framework section.</p>
        <p>2. Fit score data set: Out of 9055 masked faces that we obtained from the previous data set, we selected 504 images with different poses and a wide variety of mask designs. Then, we annotated these images using Label Studio [<xref ref-type="bibr" rid="ref28">28</xref>] for getting pixel-level annotations of the mask region on the face. This data set was then used to train a semantic segmentation model, whose details are in the Proposed Framework section.</p>
        <p>3. USA cities Instagram data set: For the analysis phase, we collected location-tagged public posts from Instagram between February 1, 2020, and May 31, 2020, for the following 6 cities: New York City, Seattle, Dallas, New Orleans, Minneapolis, and Boston. The first COVID case was reported in January 2020 [<xref ref-type="bibr" rid="ref29">29</xref>], and till July 2020, the United States was still in the first wave of the COVID-19 pandemic [<xref ref-type="bibr" rid="ref30">30</xref>]. Hence, the chosen time frame captures the beginning and growth of the COVID-19 pandemic in the United States. This collection was done for 6 major US cities, and these 6 cities were selected to represent different geographical sections of the country. We collected a total of 2.04 million public posts from these 6 cities. These posts were collected via Instagram’s explore location feature. Instagram’s GraphQL application programming interface was employed for the data collection. The tools used have been published as a python PyPI package [<xref ref-type="bibr" rid="ref31">31</xref>]. We also collected 195,452 posts for New York City and Minneapolis from May 25, 2020, to July 15, 2020, which had major protests [<xref ref-type="bibr" rid="ref32">32</xref>]. We curated a list of trending tags and keywords (“blm,” “blacklivesmatter,” “georgefloyd,” “justiceforgeorgefloyd,” “policebrutality,” and “protest”) during this period. We refer to the posts whose captions included these tags as BLM posts and the rest as non-BLM posts.</p>
      </sec>
      <sec>
        <title>Proposed Framework</title>
        <p>This article proposes a mask-unmask classification framework (for classifying masked and unmasked images) and a fit score analysis framework (for evaluating whether the masks are being worn effectively or not in the given image). The mask-unmask classification model is used to analyze the USA cities Instagram data set. The fit score analysis framework is just used for BLM posts to capture the mask use patterns during a huge social gathering.</p>
        <p>Images obtained from sources mentioned in the previous section consisted of various individuals. Thereby, to detect face masks in these images, the first task of both frameworks was face detection. This was done using the pretrained model Retinaface [<xref ref-type="bibr" rid="ref33">33</xref>], which is one of the top performing models on Face Detection on the WIDER Face (Hard) data set [<xref ref-type="bibr" rid="ref34">34</xref>]. Next, facial landmarks were obtained using Dlib’s implementation [<xref ref-type="bibr" rid="ref35">35</xref>] (proposed by Kazemi et al [<xref ref-type="bibr" rid="ref36">36</xref>]), which was used to extract the regions of interest (ROIs), as shown in <xref rid="figure1" ref-type="fig">Figure 1</xref>A. The landmarks 5-13, 31-36, and 49-68 (<xref rid="figure1" ref-type="fig">Figure 1</xref>B) were used to filter the face’s jaw region. This jaw region obtained was then used as input in the classification model for the mask-unmask classification framework. The landmarks 32-36 and 49-68 (<xref rid="figure1" ref-type="fig">Figure 1</xref>B) were used to filter the nose-mouth region from the face. This nose-mouth region obtained was then used for calculating the fit score.</p>
        <p>The jaw region was then classified on the basis of whether it contained a mask over it or not (<xref rid="figure1" ref-type="fig">Figure 1</xref>A) using a classification model. The following architectures were experimented with while training the mask-unmask classification model: MobileNet V2, Nas Net, EffecientNet B0, EffecientNet B1, EffecientNet B2, and DenseNet121. These architectures were selected since they have significantly fewer parameters than most other architectures (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). The input image size for all the models was 224×224. Transfer learning was used, and weight initialization of all models was done using ImageNet. All models were truncated at the last fully connected layer. The following layers were added: (1) average pooling with 5×5 pool size, (2) flatten layer, (3) dense layer with 128 hidden units and reLU activation, (4) dropout layer of 0.5, and (5) dense layer of 2 hidden units and Softmax activation. Adam optimizer with an initial learning rate of 1e-4 was used, and each model was trained for 30 epochs with a batch size of 64, with binary cross-entropy as the loss function. For training the classifier, the total data from the mask-unmask classifier data set consisted of 9055 masked and 9055 unmasked samples, which were split in an 80:20 ratio for training and validation sets. Five-fold cross-validation was used to evaluate the trained models’ performance, and the different model results can be found in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>(A) Face mask detection and mask fit calculation framework. The extracted jaws are passed to the trained mask-unmask classification model. The extracted nose-mouth region is given to the segmentation model to predict the masked region and calculate the fit score. (B) Facial landmarks detected on a face using Dlib. ROI: region of interest.</p>
          </caption>
          <graphic xlink:href="publichealth_v8i1e26868_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>The evaluation indicated that EfficientNet B0 was the best performing model, with an overall accuracy of 0.98 (SD 0.01). EfficientNet [<xref ref-type="bibr" rid="ref37">37</xref>] is a convolutional neural network architecture and scaling method that uniformly scales all depth/width/resolution dimensions. Efficient B0 has 5.3 million parameters with 18 layers. Its architecture consists of an initial 3×3 convolution layer, followed by a series of MBconv layers with different kernel sizes and number of channels. The series of MBconv layers are followed by a convolution layer, a pooling layer, and a fully connected layer. It uses linear activation in the last layer in each block to prevent loss of information from ReLU. Compared with conventional convolutional neural network models, the main building block for EfficientNet is MBConv, an inverted bottleneck conv, known initially as MobileNetV2. Before EfficientNet came along, the most common way to scale up ConvNet was by one of the following 3 dimensions: depth (number of layers), width (number of channels), and image resolution (image size). EfficientNet, on the other hand, performs compound scaling, that is, scaling of all 3 dimensions while maintaining a balance between all dimensions of the network. We used this trained model for further analysis using the mask-unmask classification framework.</p>
        <p>To calculate the fit score of the appropriate region covering the nose and mouth regions of the face, we used a semantic segmentation-based model (<xref rid="figure1" ref-type="fig">Figure 1</xref>A). We defined the fit score as shown in Equation 1. Using the data from the fit score data set, we trained a U-Net–based model [<xref ref-type="bibr" rid="ref38">38</xref>] for segmenting images of faces into the masked and unmasked regions. The model uses ResNet 32 and 50 encoders pretrained on ImageNet data [<xref ref-type="bibr" rid="ref39">39</xref>]. The layers were trained progressively using cyclical learning rates [<xref ref-type="bibr" rid="ref40">40</xref>]. Different model variations were experimented with using different encoders and input image sizes (<xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>). Using the output of this model (true positive [TP] + false positive [FP]) and the nose-mouth region’s facial landmarks, we calculated the fit score of an image of a face. The fit score is the percentage of ROI area covered by the mask on the face (<xref rid="figure1" ref-type="fig">Figure 1</xref>A). We employed the fit score analysis framework on BLM posts to understand how well people wore masks in groups during large events like protests. City-wise analysis was done to observe mask fit differences across major states of protest.</p>
        <p>
          <disp-formula>
            <graphic xlink:href="publichealth_v8i1e26868_fig5.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </disp-formula>
        </p>
      </sec>
      <sec>
        <title>Statistical Tests</title>
        <p>We used the Mann-Kendall trend test to look for monotonic increasing trends in the daily percentage of mask users.</p>
        <p>We also used Pearson correlation, Spearman rank-sum correlation, and the Welch <italic>t</italic> test to perform our analysis. Although Pearson correlation assumes normal distribution for both variables [<xref ref-type="bibr" rid="ref41">41</xref>], it has been shown to reveal hidden correlations even when data are not normally distributed [<xref ref-type="bibr" rid="ref42">42</xref>].</p>
        <p>We performed Pearson and Spearman correlations to decide whether the value of the correlation coefficient <italic>r</italic> between lagged COVID-19 cases and the daily percentage of people wearing masks is significantly different from 0 at a threshold of <italic>P</italic>&#60;.01 [<xref ref-type="bibr" rid="ref43">43</xref>].</p>
        <p>We then conducted the Welch <italic>t</italic> test to assess whether the daily posting is significantly affected by stay-at-home laws. The Welch <italic>t</italic> test requires normal distribution as a prerequisite, but since we were comparing mean values and our underlying series length was large (&#62;30), this assumption could be bypassed [<xref ref-type="bibr" rid="ref44">44</xref>]. We assessed the before and after posting effects of the application of stay-at-home laws in New York, Dallas, Seattle, Boston, Minneapolis, and New Orleans (<xref ref-type="supplementary-material" rid="app3">Multimedia Appendix 3</xref>) [<xref ref-type="bibr" rid="ref45">45</xref>-<xref ref-type="bibr" rid="ref50">50</xref>]. We perform the Welch <italic>t</italic> test to test the following hypotheses for the 6 cities and calculate the <italic>P</italic> values with an alpha of .01: H0, μ0=μ1 (the daily percentage of group posting is not affected by the stay-at-home laws) and H1, μ0≠μ1 (the daily percentage of group posting is affected by the stay-at-home laws), where μ0 and μ1 are the mean percentages of daily group posting.</p>
        <p>In addition, we performed the Welch <italic>t</italic> test to test the effect on the percentage of masked faces from mask mandates for Boston, Minneapolis, and New York City (mask mandate dates for the other 3 cities did not lie in our chosen timeframe) (<xref ref-type="supplementary-material" rid="app4">Multimedia Appendix 4</xref>) [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>]. The hypotheses are as follows: H0, μ0=μ1 (the daily percentage of masked faces is not affected by the mask mandates) and H1, μ0≠μ1 (the daily percentage of masked faces is affected by the mask mandates), where μ0 and μ1 are the daily mean percentages of masked faces. We calculated the associated <italic>P</italic> value for significance testing, with an alpha of .01.</p>
      </sec>
      <sec>
        <title>Interpretability</title>
        <p>To visually inspect what the trained EfficientNet B0 in the mask-unmask classifier had learned, we implemented GradCam [<xref ref-type="bibr" rid="ref53">53</xref>] on the network. GradCam assesses which parts of the input image have the highest activation values, given a target class. In this case, we passed the jaw region (ROI) after facial landmark detection as the input image to the GradCam network for 3 examples (2 masked and 1 unmasked) (<xref rid="figure2" ref-type="fig">Figure 2</xref>A). We also inspected the segmentation model on the corpus of BLM posts collected from social media.</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>(A) GradCam analysis showing the activation of different regions on the jaw in the classification model. (B) Percentage of faces vs fit score for New York and Minneapolis for Black Lives Matter posts between May 25, 2020, and July 15, 2020. A total of 11,214 posts were analyzed. ROI: region of interest.</p>
          </caption>
          <graphic xlink:href="publichealth_v8i1e26868_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <p>The corresponding activation maps, mask predictions, and fit scores from GradCam analysis are shown in <xref rid="figure2" ref-type="fig">Figure 2</xref>A. <xref rid="figure2" ref-type="fig">Figure 2</xref>B shows the distribution of the fit scores for people wearing masks in BLM posts. Approximately 35% of the detected faces had a fit score ≥80% (the corresponding n/N values can be found in <xref ref-type="supplementary-material" rid="app5">Multimedia Appendix 5</xref>). This means that the remaining 65% had some significant part of their nose/mouth region not covered.</p>
      <p>The following paragraph presents the results of experiments conducted to evaluate the patterns of people wearing masks in the 6 cities across the selected time frame (February 1, 2020, and May 31, 2020). A total of 1.66 million faces were detected from all the posts across the 6 cities. Out of which, a total of 232,706 faces had masks. <xref ref-type="table" rid="table1">Table 1</xref> shows the city-wise distribution of the detected faces and masks. We found that 1.16 million posts (around 57% of the total posts collected) had no faces, while 1.89 million (around 93%) of the total posts had no masked faces. One or more faces were detected in 0.87 million (43%) of the posts, of which 0.61 million (30%) had a single face detected and 0.26 million (13%) had multiple faces detected. In 0.14 million (7%) of the total posts, one or more masked faces were detected, out of which 0.12 million (6%) had a single masked face.</p>
      <p>There was a decrease in group posting after the lockdown week. The average percentage of group pictures dropped from 8.05% to 4.65%. A sudden spike in group posting was observed around week 15 (<xref rid="figure3" ref-type="fig">Figure 3</xref>A).</p>
      <p>A general increasing trend in the percentage of people wearing masks for all 6 cities was observed. The Mann-Kendall trend test showed a significant positive trend in the daily percentage of mask users for all 6 cities (corresponding <italic>P</italic> values can be found in <xref ref-type="supplementary-material" rid="app6">Multimedia Appendix 6</xref>). New York City, Dallas, Seattle, New Orleans, Boston, and Minneapolis observed a month-wise increase of 5%, 7.4%, 7.4%, 6.5%, 5.6%, and 7.1%, respectively, between February 2020 and May 2020 (<xref rid="figure3" ref-type="fig">Figure 3</xref>C) (the corresponding n/N values can be found in <xref ref-type="supplementary-material" rid="app7">Multimedia Appendix 7</xref>).</p>
      <p>As shown in <xref rid="figure3" ref-type="fig">Figure 3</xref>B, the differences in group pictures between BLM and non-BLM posts were 6.2% and 8.3% for New York City and Minneapolis, respectively. The differences in the percentage of masked faces in group pictures between BLM and non-BLM posts were 29.0% and 20.1% for New York City and Minneapolis, respectively (<xref rid="figure3" ref-type="fig">Figure 3</xref>F).</p>
      <p><xref rid="figure3" ref-type="fig">Figure 3</xref>D shows the average daily percentage of people wearing masks before and after the state mask mandates were applied for the 3 cities that implemented these mandates within our selected time range. Boston, Minneapolis, and New York City saw increases of 3.0%, 7.4%, and 1.0%, respectively, after applying mask mandates (the corresponding n/N values can be found in <xref ref-type="supplementary-material" rid="app8">Multimedia Appendix 8</xref>). The average daily percentages of people wearing masks before and after the state mask mandates were applied were statistically different from one another for Boston and Minneapolis, with an alpha of .01, while the difference was not significant for New York City (test results can be found in <xref ref-type="supplementary-material" rid="app9">Multimedia Appendix 9</xref>).</p>
      <p>Boston, Minneapolis, New Orleans, Dallas, Seattle, and New York City saw decreases of 2.0%,1.6%, 0.6%, 2.8%, 1.3%, and 1.0%, respectively, in the average daily percentage of group pictures before and after the stay-at-home laws (the corresponding n/N values can be found in <xref ref-type="supplementary-material" rid="app10">Multimedia Appendix 10</xref>) (<xref rid="figure3" ref-type="fig">Figure 3</xref>E). The average daily percentages of group posting before and after the stay-at-home laws were applied were statistically different from one another for all the 6 cities, with the alpha value set at .01 (test results can be found in <xref ref-type="supplementary-material" rid="app11">Multimedia Appendix 11</xref>).</p>
      <table-wrap position="float" id="table1">
        <label>Table 1</label>
        <caption>
          <p>City-wise distribution of the number of detected faces, number of detected masks, and number of masks per face through our framework, collected from Instagram between February 1, 2020, and May 31, 2020.</p>
        </caption>
        <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
          <col width="200"/>
          <col width="200"/>
          <col width="200"/>
          <col width="200"/>
          <col width="200"/>
          <thead>
            <tr valign="top">
              <td>City</td>
              <td>Total collected posts, n</td>
              <td>Faces detected, n</td>
              <td>Masks detected, n</td>
              <td>Percentage of faces with masks</td>
            </tr>
          </thead>
          <tbody>
            <tr valign="top">
              <td>New York City</td>
              <td>245,677</td>
              <td>200,089</td>
              <td>25,413</td>
              <td>12.70</td>
            </tr>
            <tr valign="top">
              <td>Dallas</td>
              <td>540,500</td>
              <td>444,194</td>
              <td>48,119</td>
              <td>10.83</td>
            </tr>
            <tr valign="top">
              <td>Seattle</td>
              <td>437,040</td>
              <td>312,012</td>
              <td>46,019</td>
              <td>14.75</td>
            </tr>
            <tr valign="top">
              <td>Minneapolis</td>
              <td>220,999</td>
              <td>152,822</td>
              <td>30,385</td>
              <td>19.88</td>
            </tr>
            <tr valign="top">
              <td>New Orleans</td>
              <td>315,082</td>
              <td>321,591</td>
              <td>39,420</td>
              <td>12.26</td>
            </tr>
            <tr valign="top">
              <td>Boston</td>
              <td>283,757</td>
              <td>238,770</td>
              <td>43,350</td>
              <td>18.15</td>
            </tr>
            <tr valign="top">
              <td>Total</td>
              <td>2,043,055</td>
              <td>1,669,478</td>
              <td>232,706</td>
              <td>13.94</td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <fig id="figure3" position="float">
        <label>Figure 3</label>
        <caption>
          <p>(A) Weekly percentages of group pictures detected from New York City, Seattle, Dallas, New Orleans, Minneapolis, and Boston between February 1, 2020, and May 31, 2020. A total of 2.04 million posts were analyzed. (B) Percentage of group pictures vs city for Black Lives Matter (BLM) and non-BLM posts between May 25, 2020, and July 15, 2020. A total of 192,854 posts were analyzed. (C) Monthly percentages of people wearing masks for each of the 6 cities, between February 1, 2020, and May 31, 2020. The data set was divided into months for each city, and the percentages of people wearing masks were computed. (D) Average daily percentage of people wearing masks before and after mask use guidelines for New York, Boston, and Minneapolis, between February 1, 2020, and May 31, 2020. A total of 750,433 posts were analyzed. (E) Average daily percentage of group pictures before and after stay-at-home laws for the 6 cities between February 1, 2020, and May 31, 2020. A total of 2.04 million posts were analyzed. (F) Percentage of people wearing masks in groups for BLM and non-BLM posts between May 25, 2020, and July 15, 2020. A total of 27,789 posts were analyzed.</p>
        </caption>
        <graphic xlink:href="publichealth_v8i1e26868_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </fig>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>The COVID-19 pandemic has given the entire research community and governments a chance to reflect on what kind of system needs to be in place to handle such catastrophes. A renewed focus is emerging in infodemiology [<xref ref-type="bibr" rid="ref54">54</xref>], especially leveraging mass surveillance data [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. Location tracking [<xref ref-type="bibr" rid="ref57">57</xref>], periodic self-checks, and image recognition systems have been deployed by many governments [<xref ref-type="bibr" rid="ref58">58</xref>-<xref ref-type="bibr" rid="ref61">61</xref>] to get a handle on the pulse of the pandemic in their states. This study suggests another such approach, which can be applied to specific demographics to achieve similar near–real-time tracking of the pandemic’s spread. Instagram and other social media platforms have been very successful in tracking the number of visits to public places [<xref ref-type="bibr" rid="ref62">62</xref>]. In the context of COVID-19, public places are the focal points for the spread of the virus. It has been well-documented that face masks and social distancing are the 2 most effective nonpharmaceutical interventions to curb the spread of COVID-19 [<xref ref-type="bibr" rid="ref7">7</xref>]. However, the use of masks and effective social distancing are often self-reported [<xref ref-type="bibr" rid="ref63">63</xref>], without any proof to corroborate the claims. Models built on image data with location data [<xref ref-type="bibr" rid="ref64">64</xref>] can be a powerful tool for the authorities to keep track of the pandemic’s pulse.</p>
        <p>An overall decrease in group posting was found as the pandemic grew and lockdowns were put in place. These group pictures posted online can be used as an estimator for the percentage of people spending time in groups. A sudden spike in group posting was found from May 16, 2020, to May 22, 2020 (week 15 of our timeline). This can be linked to the easing lockdown restrictions through weeks 13, 14, and 15 [<xref ref-type="bibr" rid="ref65">65</xref>-<xref ref-type="bibr" rid="ref68">68</xref>]. As the pandemic spread, the percentage of mask users saw a significant increasing trend for all the 6 cities through the months, suggesting that more people started wearing masks as the pandemic spread. Significant positive Spearman and Pearson correlations were found between the daily COVID-19 cases and the percentage of mask users for all the cities, except New York City, with an alpha of .01 (<xref ref-type="supplementary-material" rid="app12">Multimedia Appendices 12</xref> and <xref ref-type="supplementary-material" rid="app13">13</xref>). The maximum correlation was found to be with lag as 1 for all cities, except Minneapolis, as seen in <xref rid="figure4" ref-type="fig">Figure 4</xref>. As seen through social media, the stay-at-home state policies were successful as a significant decrease in group posting was observed on the adoption of stay-at-home laws for all 6 analyzed cities. After the mask use mandates were applied, a significant increase in the percentage of mask users was seen in Boston and Minneapolis, and a slight increase was observed in New York City. These results indicate adherence to nonpharmaceutical interventions in the 6 cities, with varying percentages of changes and effects. The trends of increasing mask use with the pandemic and positive changes with mask mandates corroborate with self-reported number-based survey methods in the United States [<xref ref-type="bibr" rid="ref7">7</xref>]. Although a significant increase was seen in the percentages, the growth could have increased separately from the mandates. With an insignificant increase seen for New York City, supplemental public health interventions can be applied to maximize the adoption of such methods.</p>
        <p>A large difference was observed in the percentage of group pictures between the posts that talked about the BLM protests. This difference can be explained by the huge collection of people in protests, with a lack of social distancing measures causing a high percentage of posts to involve group pictures. On the contrary, mask use was found to be much higher for BLM-related posts as compared to non-BLM posts. The mask fit score distribution of the protestors showed that only 35% of mask users had more than 80% of their nose/mouth region covered. This indicates that, while social distancing measures were not appropriately followed due to the nature of such large gatherings, protestors were more likely to wear a mask than the general public, but only a small percentage covered their faces properly, as seen through social media posts.</p>
        <p>Models built on image data with location data can be powerful tools for authorities to keep track of the pandemic’s pulse. This study provides a new method for governments and organizations to monitor policy decisions indirectly.</p>
        <fig id="figure4" position="float">
          <label>Figure 4</label>
          <caption>
            <p>Pearson correlation between daily lagged cumulative cases and the percentage of masked photos between February 1, 2020 and May 31, 2020. The length of the series was 120. The lag was selected between 0 and 7 based on the highest correlation value.</p>
          </caption>
          <graphic xlink:href="publichealth_v8i1e26868_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>The images present in our data sets have a high definition and are in RGB mode. If the trained models have to be deployed in a new setting (eg, CCTV feed), certain image augmentation techniques like gray scaling and rescaling might be needed to fine-tune the models. For the analysis, we chose the image data from 6 major US cities by population and correlated the data with state-wide COVID-19 cases. Since these cities are some of the most populated cities of their respective states, it is reasonable to assume that they will be the hotbeds of COVID-19 spread in their respective states.</p>
        <p>The analysis was conducted using images obtained from the social media platform Instagram. We understand that these images might not represent the entire city population [<xref ref-type="bibr" rid="ref69">69</xref>]. However, they do represent a wide demographic of internet users [<xref ref-type="bibr" rid="ref70">70</xref>]. With recent studies conducted on geo-tagged text data present in Instagram posts [<xref ref-type="bibr" rid="ref71">71</xref>], our assumption of a fair population representation in the Instagram data might not be too far-fetched. Among the mask users, celebrity posts (posts with likes greater than 10,000) contributed to only 0.2% of the total posts, which contained at least one mask, showing that the collected data mainly involved posts from the general population. However, we do acknowledge that capturing metadata for users while performing similar studies might yield a conclusive answer to the question of fair representation. Capturing and using metadata can be future work, which will build on our results.</p>
      </sec>
      <sec>
        <title>Future Work</title>
        <p>An addition to the modeling pipeline could be an indoor/outdoor environment detector, similar to that in the study by Zhou et al [<xref ref-type="bibr" rid="ref72">72</xref>]. Another addition to the analysis could be selectively looking at the specific activity of users, who are deemed as “influencers” on the network. Their activity on the network can be analyzed in conjunction with the activity of their followers. This can help determine the role of social networks and the power of certain influential nodes in that network over other people’s behavior during critical times such as a pandemic. Dynamic location relationships present in mobility data [<xref ref-type="bibr" rid="ref73">73</xref>] can be further used to understand the pandemic’s spread with higher location precision and even recognize malevolent actors in the system. A natural extension of this work is its replication across different social media platforms like Twitter, Facebook, and Baidu.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>Models built on image data with location data can be powerful tools for authorities to keep track of the pandemic’s pulse. This study examined 2.04 million posts collected from 6 US cities between February 1, 2020, and May 31, 2020, for adherence to mask use and social distancing, as seen through social media.</p>
        <p>This study found a general increasing trend in mask use and a decreasing trend in group pictures as the pandemic spread. The stay-at-home laws caused a significant drop in group posting for all 6 cities, while the mask mandates caused a significant increase in mask use for 2 of the 3 cities analyzed. Although these results suggest an upward trend in the adoption of preventive methods, a large portion of nonadopters seen online indicates a need for supplemental measures to increase the effectiveness of such methods.</p>
        <p>Posts related to protests were found to capture the lack of attention given to safety measures, with high percentages of detected group pictures and incorrect mask use. The methodology used provides a directional indication of how government policies can be indirectly monitored. The findings can help governments and other organizations as indicators for the successful implementation of nonpharmaceutical interventions for the COVID-19 pandemic.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>Face mask detection model results.</p>
        <media xlink:href="publichealth_v8i1e26868_app1.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Face mask fit analyzer model results.</p>
        <media xlink:href="publichealth_v8i1e26868_app2.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app3">
        <label>Multimedia Appendix 3</label>
        <p>Dates on which stay-at-home guidelines were enacted by the respective state governments.</p>
        <media xlink:href="publichealth_v8i1e26868_app3.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app4">
        <label>Multimedia Appendix 4</label>
        <p>Dates on which mask mandates were enacted by the respective state governments.</p>
        <media xlink:href="publichealth_v8i1e26868_app4.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app5">
        <label>Multimedia Appendix 5</label>
        <p>Underlying n and N values for Figure 2B.</p>
        <media xlink:href="publichealth_v8i1e26868_app5.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app6">
        <label>Multimedia Appendix 6</label>
        <p>Test statistics and <italic>P</italic> values for the Mann-Kendall trend test for the daily percentage of mask wearers in 6 cities.</p>
        <media xlink:href="publichealth_v8i1e26868_app6.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app7">
        <label>Multimedia Appendix 7</label>
        <p>Underlying n and N values for Figure 3C.</p>
        <media xlink:href="publichealth_v8i1e26868_app7.docx" xlink:title="DOCX File , 14 KB"/>
      </supplementary-material>
      <supplementary-material id="app8">
        <label>Multimedia Appendix 8</label>
        <p>Underlying n and N values for Figure 3D.</p>
        <media xlink:href="publichealth_v8i1e26868_app8.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app9">
        <label>Multimedia Appendix 9</label>
        <p>Welch <italic>t</italic> test statistics and <italic>P</italic> values to test for equal means before and after the application of mask mandates.</p>
        <media xlink:href="publichealth_v8i1e26868_app9.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app10">
        <label>Multimedia Appendix 10</label>
        <p>Underlying n and N values for Figure 3E.</p>
        <media xlink:href="publichealth_v8i1e26868_app10.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app11">
        <label>Multimedia Appendix 11</label>
        <p>Welch <italic>t</italic> test statistics and <italic>P</italic> values to test for equal means before and after the application of stay-at-home orders.</p>
        <media xlink:href="publichealth_v8i1e26868_app11.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app12">
        <label>Multimedia Appendix 12</label>
        <p>Pearson correlation coefficients and <italic>P</italic> values between lagged cumulative COVID-19 cases and the daily percentage of people wearing masks.</p>
        <media xlink:href="publichealth_v8i1e26868_app12.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
      <supplementary-material id="app13">
        <label>Multimedia Appendix 13</label>
        <p>Spearman correlation coefficients and <italic>P</italic> values between lagged cumulative COVID-19 cases and the daily percentage of people wearing masks.</p>
        <media xlink:href="publichealth_v8i1e26868_app13.docx" xlink:title="DOCX File , 13 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">BLM</term>
          <def>
            <p>Black Lives Matter</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">MAFA</term>
          <def>
            <p>Masked Face</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">RMFD</term>
          <def>
            <p>Real-world Masked Face Dataset</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">ROI</term>
          <def>
            <p>region of interest</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>This work was supported by the Delhi Cluster-Delhi Research Implementation and Innovation (DRIIV) Project supported by the Principal Scientific Advisor Office, Prn.SA/Delhi/Hub/2018(C) and the Center of Excellence in Healthcare supported by Delhi Knowledge Development Foundation (DKDF) at IIIT-Delhi.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
    <ref-list>
      <ref id="ref1">
        <label>1</label>
        <nlm-citation citation-type="web">
          <article-title>WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020</article-title>
          <source>World Health Organization</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020">https://tinyurl.com/m33paaee</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref2">
        <label>2</label>
        <nlm-citation citation-type="web">
          <source>Johns Hopkins Coronavirus Resource Center</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://coronavirus.jhu.edu/">https://coronavirus.jhu.edu/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref3">
        <label>3</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Nossiter</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Minder</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Povoledo</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Erlanger</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Restrictions on Movement Grow as Governments Try to Slow Coronavirus</article-title>
          <source>The New York Times</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.nytimes.com/2020/03/15/world/coronavirus-world-response.html">https://www.nytimes.com/2020/03/15/world/coronavirus-world-response.html</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref4">
        <label>4</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Petersen</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>McCloskey</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Hui</surname>
              <given-names>DS</given-names>
            </name>
            <name name-style="western">
              <surname>Kock</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Ntoumi</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Memish</surname>
              <given-names>ZA</given-names>
            </name>
            <name name-style="western">
              <surname>Kapata</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Azhar</surname>
              <given-names>EI</given-names>
            </name>
            <name name-style="western">
              <surname>Pollack</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Madoff</surname>
              <given-names>LC</given-names>
            </name>
            <name name-style="western">
              <surname>Hamer</surname>
              <given-names>DH</given-names>
            </name>
            <name name-style="western">
              <surname>Nachega</surname>
              <given-names>JB</given-names>
            </name>
            <name name-style="western">
              <surname>Pshenichnaya</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Zumla</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>COVID-19 travel restrictions and the International Health Regulations - Call for an open debate on easing of travel restrictions</article-title>
          <source>Int J Infect Dis</source>
          <year>2020</year>
          <month>05</month>
          <volume>94</volume>
          <fpage>88</fpage>
          <lpage>90</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(20)30245-9"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.ijid.2020.04.029</pub-id>
          <pub-id pub-id-type="medline">32305518</pub-id>
          <pub-id pub-id-type="pii">S1201-9712(20)30245-9</pub-id>
          <pub-id pub-id-type="pmcid">PMC7162781</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref5">
        <label>5</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chu</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Duda</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Solo</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Yaacoub</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Schunemann</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Physical Distancing, Face Masks, and Eye Protection to Prevent Person-to-Person Transmission of SARS-CoV-2 and COVID-19: A Systematic Review and Meta-Analysis</article-title>
          <source>Journal of Vascular Surgery</source>
          <year>2020</year>
          <month>10</month>
          <volume>72</volume>
          <issue>4</issue>
          <fpage>1500</fpage>
          <pub-id pub-id-type="doi">10.1016/j.jvs.2020.07.040</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref6">
        <label>6</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Howard</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Huang</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Tufekci</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Zdimal</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>van der Westhuizen</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>von Delft</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Price</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Fridman</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Tang</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Tang</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Watson</surname>
              <given-names>GL</given-names>
            </name>
            <name name-style="western">
              <surname>Bax</surname>
              <given-names>CE</given-names>
            </name>
            <name name-style="western">
              <surname>Shaikh</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Questier</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Hernandez</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Chu</surname>
              <given-names>LF</given-names>
            </name>
            <name name-style="western">
              <surname>Ramirez</surname>
              <given-names>CM</given-names>
            </name>
            <name name-style="western">
              <surname>Rimoin</surname>
              <given-names>AW</given-names>
            </name>
          </person-group>
          <article-title>An evidence review of face masks against COVID-19</article-title>
          <source>Proc Natl Acad Sci U S A</source>
          <year>2021</year>
          <month>01</month>
          <day>26</day>
          <volume>118</volume>
          <issue>4</issue>
          <fpage>e2014564118</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://www.pnas.org/cgi/pmidlookup?view=long&#38;pmid=33431650"/>
          </comment>
          <pub-id pub-id-type="doi">10.1073/pnas.2014564118</pub-id>
          <pub-id pub-id-type="medline">33431650</pub-id>
          <pub-id pub-id-type="pii">2014564118</pub-id>
          <pub-id pub-id-type="pmcid">PMC7848583</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref7">
        <label>7</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Rader</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>White</surname>
              <given-names>LF</given-names>
            </name>
            <name name-style="western">
              <surname>Burns</surname>
              <given-names>MR</given-names>
            </name>
            <name name-style="western">
              <surname>Chen</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Brilliant</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Cohen</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Shaman</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Brilliant</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Kraemer</surname>
              <given-names>MUG</given-names>
            </name>
            <name name-style="western">
              <surname>Hawkins</surname>
              <given-names>JB</given-names>
            </name>
            <name name-style="western">
              <surname>Scarpino</surname>
              <given-names>SV</given-names>
            </name>
            <name name-style="western">
              <surname>Astley</surname>
              <given-names>CM</given-names>
            </name>
            <name name-style="western">
              <surname>Brownstein</surname>
              <given-names>JS</given-names>
            </name>
          </person-group>
          <article-title>Mask-wearing and control of SARS-CoV-2 transmission in the USA: a cross-sectional study</article-title>
          <source>The Lancet Digital Health</source>
          <year>2021</year>
          <month>03</month>
          <volume>3</volume>
          <issue>3</issue>
          <fpage>e148</fpage>
          <lpage>e157</lpage>
          <pub-id pub-id-type="doi">10.1016/s2589-7500(20)30293-4</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref8">
        <label>8</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Clapham</surname>
              <given-names>HE</given-names>
            </name>
            <name name-style="western">
              <surname>Cook</surname>
              <given-names>AR</given-names>
            </name>
          </person-group>
          <article-title>Face masks help control transmission of COVID-19</article-title>
          <source>The Lancet Digital Health</source>
          <year>2021</year>
          <month>03</month>
          <volume>3</volume>
          <issue>3</issue>
          <fpage>e136</fpage>
          <lpage>e137</lpage>
          <pub-id pub-id-type="doi">10.1016/s2589-7500(21)00003-0</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref9">
        <label>9</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Cheng</surname>
              <given-names>VC</given-names>
            </name>
            <name name-style="western">
              <surname>Wong</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Chuang</surname>
              <given-names>VW</given-names>
            </name>
            <name name-style="western">
              <surname>So</surname>
              <given-names>SY</given-names>
            </name>
            <name name-style="western">
              <surname>Chen</surname>
              <given-names>JH</given-names>
            </name>
            <name name-style="western">
              <surname>Sridhar</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>To</surname>
              <given-names>KK</given-names>
            </name>
            <name name-style="western">
              <surname>Chan</surname>
              <given-names>JF</given-names>
            </name>
            <name name-style="western">
              <surname>Hung</surname>
              <given-names>IF</given-names>
            </name>
            <name name-style="western">
              <surname>Ho</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Yuen</surname>
              <given-names>K</given-names>
            </name>
          </person-group>
          <article-title>The role of community-wide wearing of face mask for control of coronavirus disease 2019 (COVID-19) epidemic due to SARS-CoV-2</article-title>
          <source>J Infect</source>
          <year>2020</year>
          <month>07</month>
          <volume>81</volume>
          <issue>1</issue>
          <fpage>107</fpage>
          <lpage>114</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/32335167"/>
          </comment>
          <pub-id pub-id-type="doi">10.1016/j.jinf.2020.04.024</pub-id>
          <pub-id pub-id-type="medline">32335167</pub-id>
          <pub-id pub-id-type="pii">S0163-4453(20)30235-8</pub-id>
          <pub-id pub-id-type="pmcid">PMC7177146</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref10">
        <label>10</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Worby</surname>
              <given-names>CJ</given-names>
            </name>
            <name name-style="western">
              <surname>Chang</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>Face mask use in the general population and optimal resource allocation during the COVID-19 pandemic</article-title>
          <source>Nat Commun</source>
          <year>2020</year>
          <month>08</month>
          <day>13</day>
          <volume>11</volume>
          <issue>1</issue>
          <fpage>4049</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1038/s41467-020-17922-x"/>
          </comment>
          <pub-id pub-id-type="doi">10.1038/s41467-020-17922-x</pub-id>
          <pub-id pub-id-type="medline">32792562</pub-id>
          <pub-id pub-id-type="pii">10.1038/s41467-020-17922-x</pub-id>
          <pub-id pub-id-type="pmcid">PMC7426871</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref11">
        <label>11</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ainslie</surname>
              <given-names>KEC</given-names>
            </name>
            <name name-style="western">
              <surname>Walters</surname>
              <given-names>CE</given-names>
            </name>
            <name name-style="western">
              <surname>Fu</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Bhatia</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Xi</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Baguelin</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Bhatt</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Boonyasiri</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Boyd</surname>
              <given-names>O</given-names>
            </name>
            <name name-style="western">
              <surname>Cattarino</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Ciavarella</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Cucunuba</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Cuomo-Dannenburg</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Dighe</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Dorigatti</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>van Elsland</surname>
              <given-names>SL</given-names>
            </name>
            <name name-style="western">
              <surname>FitzJohn</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Gaythorpe</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Ghani</surname>
              <given-names>AC</given-names>
            </name>
            <name name-style="western">
              <surname>Green</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Hamlet</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Hinsley</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Imai</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Jorgensen</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Knock</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Laydon</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Nedjati-Gilani</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Okell</surname>
              <given-names>LC</given-names>
            </name>
            <name name-style="western">
              <surname>Siveroni</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Thompson</surname>
              <given-names>HA</given-names>
            </name>
            <name name-style="western">
              <surname>Unwin</surname>
              <given-names>HJT</given-names>
            </name>
            <name name-style="western">
              <surname>Verity</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Vollmer</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Walker</surname>
              <given-names>PGT</given-names>
            </name>
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Watson</surname>
              <given-names>OJ</given-names>
            </name>
            <name name-style="western">
              <surname>Whittaker</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Winskill</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Donnelly</surname>
              <given-names>CA</given-names>
            </name>
            <name name-style="western">
              <surname>Ferguson</surname>
              <given-names>NM</given-names>
            </name>
            <name name-style="western">
              <surname>Riley</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment</article-title>
          <source>Wellcome Open Res</source>
          <year>2020</year>
          <month>4</month>
          <day>28</day>
          <volume>5</volume>
          <fpage>81</fpage>
          <pub-id pub-id-type="doi">10.12688/wellcomeopenres.15843.1</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref12">
        <label>12</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Du</surname>
              <given-names>Z</given-names>
            </name>
            <name name-style="western">
              <surname>Xu</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Wang</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Fox</surname>
              <given-names>SJ</given-names>
            </name>
            <name name-style="western">
              <surname>Cowling</surname>
              <given-names>BJ</given-names>
            </name>
            <name name-style="western">
              <surname>Galvani</surname>
              <given-names>AP</given-names>
            </name>
            <name name-style="western">
              <surname>Meyers</surname>
              <given-names>LA</given-names>
            </name>
          </person-group>
          <article-title>Effects of Proactive Social Distancing on COVID-19 Outbreaks in 58 Cities, China</article-title>
          <source>Emerg Infect Dis</source>
          <year>2020</year>
          <month>09</month>
          <volume>26</volume>
          <issue>9</issue>
          <fpage>2267</fpage>
          <lpage>2269</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.3201/eid2609.201932"/>
          </comment>
          <pub-id pub-id-type="doi">10.3201/eid2609.201932</pub-id>
          <pub-id pub-id-type="medline">32516108</pub-id>
          <pub-id pub-id-type="pmcid">PMC7454087</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref13">
        <label>13</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Haischer</surname>
              <given-names>MH</given-names>
            </name>
            <name name-style="western">
              <surname>Beilfuss</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Hart</surname>
              <given-names>MR</given-names>
            </name>
            <name name-style="western">
              <surname>Opielinski</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Wrucke</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Zirgaitis</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Uhrich</surname>
              <given-names>TD</given-names>
            </name>
            <name name-style="western">
              <surname>Hunter</surname>
              <given-names>SK</given-names>
            </name>
          </person-group>
          <article-title>Who is wearing a mask? Gender-, age-, and location-related differences during the COVID-19 pandemic</article-title>
          <source>PLoS One</source>
          <year>2020</year>
          <volume>15</volume>
          <issue>10</issue>
          <fpage>e0240785</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0240785"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0240785</pub-id>
          <pub-id pub-id-type="medline">33057375</pub-id>
          <pub-id pub-id-type="pii">PONE-D-20-22615</pub-id>
          <pub-id pub-id-type="pmcid">PMC7561164</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref14">
        <label>14</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Depoux</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Martin</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Karafillakis</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Preet</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Wilder-Smith</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Larson</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>The pandemic of social media panic travels faster than the COVID-19 outbreak</article-title>
          <source>J Travel Med</source>
          <year>2020</year>
          <month>05</month>
          <day>18</day>
          <volume>27</volume>
          <issue>3</issue>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/32125413"/>
          </comment>
          <pub-id pub-id-type="doi">10.1093/jtm/taaa031</pub-id>
          <pub-id pub-id-type="medline">32125413</pub-id>
          <pub-id pub-id-type="pii">5775501</pub-id>
          <pub-id pub-id-type="pmcid">PMC7107516</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref15">
        <label>15</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Petersen</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Gerken</surname>
              <given-names>JM</given-names>
            </name>
          </person-group>
          <article-title>#Covid-19: An exploratory investigation of hashtag usage on Twitter</article-title>
          <source>Health Policy</source>
          <year>2021</year>
          <month>04</month>
          <volume>125</volume>
          <issue>4</issue>
          <fpage>541</fpage>
          <lpage>547</lpage>
          <pub-id pub-id-type="doi">10.1016/j.healthpol.2021.01.001</pub-id>
          <pub-id pub-id-type="medline">33487479</pub-id>
          <pub-id pub-id-type="pii">S0168-8510(21)00008-7</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref16">
        <label>16</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ahmad</surname>
              <given-names>AR</given-names>
            </name>
            <name name-style="western">
              <surname>Murad</surname>
              <given-names>HR</given-names>
            </name>
          </person-group>
          <article-title>The Impact of Social Media on Panic During the COVID-19 Pandemic in Iraqi Kurdistan: Online Questionnaire Study</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>05</month>
          <day>19</day>
          <volume>22</volume>
          <issue>5</issue>
          <fpage>e19556</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/5/e19556/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/19556</pub-id>
          <pub-id pub-id-type="medline">32369026</pub-id>
          <pub-id pub-id-type="pii">v22i5e19556</pub-id>
          <pub-id pub-id-type="pmcid">PMC7238863</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref17">
        <label>17</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Cinelli</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Quattrociocchi</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Galeazzi</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Valensise</surname>
              <given-names>CM</given-names>
            </name>
            <name name-style="western">
              <surname>Brugnoli</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Schmidt</surname>
              <given-names>AL</given-names>
            </name>
            <name name-style="western">
              <surname>Zola</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Zollo</surname>
              <given-names>F</given-names>
            </name>
            <name name-style="western">
              <surname>Scala</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>The COVID-19 social media infodemic</article-title>
          <source>Sci Rep</source>
          <year>2020</year>
          <month>10</month>
          <day>06</day>
          <volume>10</volume>
          <issue>1</issue>
          <fpage>16598</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1038/s41598-020-73510-5"/>
          </comment>
          <pub-id pub-id-type="doi">10.1038/s41598-020-73510-5</pub-id>
          <pub-id pub-id-type="medline">33024152</pub-id>
          <pub-id pub-id-type="pii">10.1038/s41598-020-73510-5</pub-id>
          <pub-id pub-id-type="pmcid">PMC7538912</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref18">
        <label>18</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Huang</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Xu</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Cai</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Ge</surname>
              <given-names>Q</given-names>
            </name>
            <name name-style="western">
              <surname>Zeng</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Zhang</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Ji</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Yang</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Mining the Characteristics of COVID-19 Patients in China: Analysis of Social Media Posts</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>05</month>
          <day>17</day>
          <volume>22</volume>
          <issue>5</issue>
          <fpage>e19087</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/5/e19087/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/19087</pub-id>
          <pub-id pub-id-type="medline">32401210</pub-id>
          <pub-id pub-id-type="pii">v22i5e19087</pub-id>
          <pub-id pub-id-type="pmcid">PMC7236610</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref19">
        <label>19</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Islam</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Sarkar</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Khan</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Mostofa Kamal</surname>
              <given-names>AH</given-names>
            </name>
            <name name-style="western">
              <surname>Hasan</surname>
              <given-names>SM</given-names>
            </name>
            <name name-style="western">
              <surname>Kabir</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Yeasmin</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Islam</surname>
              <given-names>MA</given-names>
            </name>
            <name name-style="western">
              <surname>Amin Chowdhury</surname>
              <given-names>KI</given-names>
            </name>
            <name name-style="western">
              <surname>Anwar</surname>
              <given-names>KS</given-names>
            </name>
            <name name-style="western">
              <surname>Chughtai</surname>
              <given-names>AA</given-names>
            </name>
            <name name-style="western">
              <surname>Seale</surname>
              <given-names>H</given-names>
            </name>
          </person-group>
          <article-title>COVID-19-Related Infodemic and Its Impact on Public Health: A Global Social Media Analysis</article-title>
          <source>Am J Trop Med Hyg</source>
          <year>2020</year>
          <month>10</month>
          <volume>103</volume>
          <issue>4</issue>
          <fpage>1621</fpage>
          <lpage>1629</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/32783794"/>
          </comment>
          <pub-id pub-id-type="doi">10.4269/ajtmh.20-0812</pub-id>
          <pub-id pub-id-type="medline">32783794</pub-id>
          <pub-id pub-id-type="pmcid">PMC7543839</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref20">
        <label>20</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Signorini</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Segre</surname>
              <given-names>AM</given-names>
            </name>
            <name name-style="western">
              <surname>Polgreen</surname>
              <given-names>PM</given-names>
            </name>
          </person-group>
          <article-title>The Use of Twitter to Track Levels of Disease Activity and Public Concern in the U.S. during the Influenza A H1N1 Pandemic</article-title>
          <source>PLoS ONE</source>
          <year>2011</year>
          <month>5</month>
          <day>4</day>
          <volume>6</volume>
          <issue>5</issue>
          <fpage>e19467</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0019467"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0019467</pub-id>
          <pub-id pub-id-type="medline">21573238</pub-id>
          <pub-id pub-id-type="pii">PONE-D-10-02464</pub-id>
          <pub-id pub-id-type="pmcid">PMC3087759</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref21">
        <label>21</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Taylor</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>George Floyd Protests: A Timeline</article-title>
          <source>The New York Times</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.nytimes.com/article/george-floyd-protests-timeline.html">https://www.nytimes.com/article/george-floyd-protests-timeline.html</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref22">
        <label>22</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mundt</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Ross</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Burnett</surname>
              <given-names>CM</given-names>
            </name>
          </person-group>
          <article-title>Scaling Social Movements Through Social Media: The Case of Black Lives Matter</article-title>
          <source>Social Media + Society</source>
          <year>2018</year>
          <month>11</month>
          <day>01</day>
          <volume>4</volume>
          <issue>4</issue>
          <fpage>205630511880791</fpage>
          <pub-id pub-id-type="doi">10.1177/2056305118807911</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref23">
        <label>23</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Cox</surname>
              <given-names>JM</given-names>
            </name>
          </person-group>
          <article-title>The source of a movement: making the case for social media as an informational source using Black Lives Matter</article-title>
          <source>Ethnic and Racial Studies</source>
          <year>2017</year>
          <month>06</month>
          <day>16</day>
          <volume>40</volume>
          <issue>11</issue>
          <fpage>1847</fpage>
          <lpage>1854</lpage>
          <pub-id pub-id-type="doi">10.1080/01419870.2017.1334935</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref24">
        <label>24</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Walsh-Buhi</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Houghton</surname>
              <given-names>RF</given-names>
            </name>
            <name name-style="western">
              <surname>Lange</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Hockensmith</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Ferrand</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Martinez</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Pre-exposure Prophylaxis (PrEP) Information on Instagram: Content Analysis</article-title>
          <source>JMIR Public Health Surveill</source>
          <year>2021</year>
          <month>07</month>
          <day>27</day>
          <volume>7</volume>
          <issue>7</issue>
          <fpage>e23876</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://publichealth.jmir.org/2021/7/e23876/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/23876</pub-id>
          <pub-id pub-id-type="medline">34061759</pub-id>
          <pub-id pub-id-type="pii">v7i7e23876</pub-id>
          <pub-id pub-id-type="pmcid">PMC8367150</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref25">
        <label>25</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ge</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Ye</surname>
              <given-names>Q</given-names>
            </name>
            <name name-style="western">
              <surname>Luo</surname>
              <given-names>Z</given-names>
            </name>
          </person-group>
          <article-title>Detecting Masked Faces in the Wild with LLE-CNNs</article-title>
          <year>2017</year>
          <conf-name>2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR)</conf-name>
          <conf-date>July 21-26, 2017</conf-date>
          <conf-loc>Honolulu, HI, USA</conf-loc>
          <pub-id pub-id-type="doi">10.1109/cvpr.2017.53</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref26">
        <label>26</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Fan</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Jiang</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>RetinaFaceMask: A Single Stage Face Mask Detector for Assisting Control of the COVID-19 Pandemic</article-title>
          <source>arXiv</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://arxiv.org/abs/2005.03950">http://arxiv.org/abs/2005.03950</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref27">
        <label>27</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Cao</surname>
              <given-names>Q</given-names>
            </name>
            <name name-style="western">
              <surname>Shen</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Xie</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Parkhi</surname>
              <given-names>O</given-names>
            </name>
            <name name-style="western">
              <surname>Zisserman</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>VGGFace2: A Dataset for Recognising Faces across Pose and Age</article-title>
          <year>2018</year>
          <conf-name>13th IEEE International Conference on Automatic Face &#38; Gesture Recognition</conf-name>
          <conf-date>May 15-19, 2018</conf-date>
          <conf-loc>Xi'an, China</conf-loc>
          <pub-id pub-id-type="doi">10.1109/fg.2018.00020</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref28">
        <label>28</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Tkachenko</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Malyuk</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Shevchenko</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Holmanyuk</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Liubimov</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <article-title>Label Studio: Data labeling software</article-title>
          <source>GitHub</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://github.com/heartexlabs/label-studio">https://github.com/heartexlabs/label-studio</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref29">
        <label>29</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Holshue</surname>
              <given-names>ML</given-names>
            </name>
            <name name-style="western">
              <surname>DeBolt</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Lindquist</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Lofy</surname>
              <given-names>KH</given-names>
            </name>
            <name name-style="western">
              <surname>Wiesman</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Bruce</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Spitters</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Ericson</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Wilkerson</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Tural</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Diaz</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Cohn</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Fox</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Patel</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Gerber</surname>
              <given-names>SI</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Tong</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Lu</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Lindstrom</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Pallansch</surname>
              <given-names>MA</given-names>
            </name>
            <name name-style="western">
              <surname>Weldon</surname>
              <given-names>WC</given-names>
            </name>
            <name name-style="western">
              <surname>Biggs</surname>
              <given-names>HM</given-names>
            </name>
            <name name-style="western">
              <surname>Uyeki</surname>
              <given-names>TM</given-names>
            </name>
            <name name-style="western">
              <surname>Pillai</surname>
              <given-names>SK</given-names>
            </name>
          </person-group>
          <article-title>First Case of 2019 Novel Coronavirus in the United States</article-title>
          <source>N Engl J Med</source>
          <year>2020</year>
          <month>03</month>
          <day>05</day>
          <volume>382</volume>
          <issue>10</issue>
          <fpage>929</fpage>
          <lpage>936</lpage>
          <pub-id pub-id-type="doi">10.1056/nejmoa2001191</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref30">
        <label>30</label>
        <nlm-citation citation-type="web">
          <article-title>US is still 'knee-deep' in the first wave of the coronavirus pandemic, Fauci says</article-title>
          <source>CNN</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://edition.cnn.com/2020/07/06/health/us-coronavirus-monday/index.html">https://edition.cnn.com/2020/07/06/health/us-coronavirus-monday/index.html</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref31">
        <label>31</label>
        <nlm-citation citation-type="web">
          <article-title>instagram-scraper</article-title>
          <source>PyPI</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://pypi.org/project/instagram-scraper/">https://pypi.org/project/instagram-scraper/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref32">
        <label>32</label>
        <nlm-citation citation-type="web">
          <article-title>Some N.Y.C. Protests Ended Quietly. Others Ended in Arrests</article-title>
          <source>The New York Times</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.nytimes.com/2020/06/05/nyregion/nyc-protests-george-floyd.html">https://www.nytimes.com/2020/06/05/nyregion/nyc-protests-george-floyd.html</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref33">
        <label>33</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Deng</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Guo</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Zhou</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Yu</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Kotsia</surname>
              <given-names>I</given-names>
            </name>
            <name name-style="western">
              <surname>Zafeiriou</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>RetinaFace: Single-stage Dense Face Localisation in the Wild</article-title>
          <source>arXiv</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://arxiv.org/abs/1905.00641">http://arxiv.org/abs/1905.00641</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref34">
        <label>34</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Yang</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Luo</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Loy</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Tang</surname>
              <given-names>X</given-names>
            </name>
          </person-group>
          <article-title>WIDER FACE: A Face Detection Benchmark</article-title>
          <year>2016</year>
          <conf-name>2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR)</conf-name>
          <conf-date>June 27-30, 2016</conf-date>
          <conf-loc>Las Vegas, NV, USA</conf-loc>
          <pub-id pub-id-type="doi">10.1109/cvpr.2016.596</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref35">
        <label>35</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>King</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Dlib-ml: A Machine Learning Toolkit</article-title>
          <source>Journal of Machine Learning Research</source>
          <year>2009</year>
          <volume>10</volume>
          <fpage>1755</fpage>
          <lpage>1758</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmlr.org/papers/volume10/king09a/king09a.pdf"/>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref36">
        <label>36</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kazemi</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Sullivan</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>One millisecond face alignment with an ensemble of regression trees</article-title>
          <year>2014</year>
          <conf-name>2014 IEEE Conference on Computer Vision and Pattern Recognition</conf-name>
          <conf-date>June 23-28, 2014</conf-date>
          <conf-loc>Columbus, OH, USA</conf-loc>
          <pub-id pub-id-type="doi">10.1109/cvpr.2014.241</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref37">
        <label>37</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Tan</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Le</surname>
              <given-names>Q</given-names>
            </name>
          </person-group>
          <article-title>EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks</article-title>
          <source>Proceedings of Machine Learning Research</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://proceedings.mlr.press/v97/tan19a.html">http://proceedings.mlr.press/v97/tan19a.html</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref38">
        <label>38</label>
        <nlm-citation citation-type="book">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Ronneberger</surname>
              <given-names>O</given-names>
            </name>
            <name name-style="western">
              <surname>Fischer</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Brox</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <person-group person-group-type="editor">
            <name name-style="western">
              <surname>Navab</surname>
              <given-names>N</given-names>
            </name>
            <name name-style="western">
              <surname>Hornegger</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Wells</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Frangi</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>U-Net: Convolutional Networks for Biomedical Image Segmentation</article-title>
          <source>Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015. MICCAI 2015. Lecture Notes in Computer Science, vol 9351</source>
          <year>2015</year>
          <publisher-loc>Cham</publisher-loc>
          <publisher-name>Springer</publisher-name>
          <fpage>234</fpage>
          <lpage>241</lpage>
        </nlm-citation>
      </ref>
      <ref id="ref39">
        <label>39</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Deng</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Dong</surname>
              <given-names>W</given-names>
            </name>
            <name name-style="western">
              <surname>Socher</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>LJ</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Fei-Fei</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>ImageNet: A large-scale hierarchical image database</article-title>
          <year>2009</year>
          <conf-name>2009 IEEE Conference on Computer Vision and Pattern Recognition</conf-name>
          <conf-date>June 20-25, 2009</conf-date>
          <conf-loc>Miami, FL, USA</conf-loc>
          <fpage>248</fpage>
          <lpage>255</lpage>
          <pub-id pub-id-type="doi">10.1109/CVPR.2009.5206848</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref40">
        <label>40</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Smith</surname>
              <given-names>LN</given-names>
            </name>
          </person-group>
          <article-title>A disciplined approach to neural network hyper-parameters: Part 1 -- learning rate, batch size, momentum, and weight decay</article-title>
          <source>arXiv</source>
          <access-date>2021-04-20</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://arxiv.org/abs/1803.09820">https://arxiv.org/abs/1803.09820</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref41">
        <label>41</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Mukaka</surname>
              <given-names>MM</given-names>
            </name>
          </person-group>
          <article-title>Statistics corner: A guide to appropriate use of correlation coefficient in medical research</article-title>
          <source>Malawi Med J</source>
          <year>2012</year>
          <month>09</month>
          <volume>24</volume>
          <issue>3</issue>
          <fpage>69</fpage>
          <lpage>71</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/23638278"/>
          </comment>
          <pub-id pub-id-type="medline">23638278</pub-id>
          <pub-id pub-id-type="pmcid">PMC3576830</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref42">
        <label>42</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Rovetta</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Raiders of the Lost Correlation: A Guide on Using Pearson and Spearman Coefficients to Detect Hidden Correlations in Medical Sciences</article-title>
          <source>Cureus</source>
          <year>2020</year>
          <month>11</month>
          <day>30</day>
          <volume>12</volume>
          <issue>11</issue>
          <fpage>e11794</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/33409040"/>
          </comment>
          <pub-id pub-id-type="doi">10.7759/cureus.11794</pub-id>
          <pub-id pub-id-type="medline">33409040</pub-id>
          <pub-id pub-id-type="pmcid">PMC7779167</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref43">
        <label>43</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Greenland</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Senn</surname>
              <given-names>SJ</given-names>
            </name>
            <name name-style="western">
              <surname>Rothman</surname>
              <given-names>KJ</given-names>
            </name>
            <name name-style="western">
              <surname>Carlin</surname>
              <given-names>JB</given-names>
            </name>
            <name name-style="western">
              <surname>Poole</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Goodman</surname>
              <given-names>SN</given-names>
            </name>
            <name name-style="western">
              <surname>Altman</surname>
              <given-names>DG</given-names>
            </name>
          </person-group>
          <article-title>Statistical tests, <italic>P</italic> values, confidence intervals, and power: a guide to misinterpretations</article-title>
          <source>Eur J Epidemiol</source>
          <year>2016</year>
          <month>04</month>
          <day>21</day>
          <volume>31</volume>
          <issue>4</issue>
          <fpage>337</fpage>
          <lpage>50</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/27209009"/>
          </comment>
          <pub-id pub-id-type="doi">10.1007/s10654-016-0149-3</pub-id>
          <pub-id pub-id-type="medline">27209009</pub-id>
          <pub-id pub-id-type="pii">10.1007/s10654-016-0149-3</pub-id>
          <pub-id pub-id-type="pmcid">PMC4877414</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref44">
        <label>44</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kwak</surname>
              <given-names>SG</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>JH</given-names>
            </name>
          </person-group>
          <article-title>Central limit theorem: the cornerstone of modern statistics</article-title>
          <source>Korean J Anesthesiol</source>
          <year>2017</year>
          <month>04</month>
          <volume>70</volume>
          <issue>2</issue>
          <fpage>144</fpage>
          <lpage>156</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://ekja.org/journal/view.php?doi=10.4097/kjae.2017.70.2.144"/>
          </comment>
          <pub-id pub-id-type="doi">10.4097/kjae.2017.70.2.144</pub-id>
          <pub-id pub-id-type="medline">28367284</pub-id>
          <pub-id pub-id-type="pmcid">PMC5370305</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref45">
        <label>45</label>
        <nlm-citation citation-type="web">
          <article-title>Coronavirus Disease (COVID-19) timeline</article-title>
          <source>City of Boston</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.boston.gov/departments/public-health-commission/coronavirus-timeline">https://www.boston.gov/departments/public-health-commission/coronavirus-timeline</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref46">
        <label>46</label>
        <nlm-citation citation-type="web">
          <article-title>Governor Walz Issues Stay at Home Order for Minnesotans</article-title>
          <source>State of Minnesota</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://mn.gov/governor/covid-19/news/?id=1055-424820">https://mn.gov/governor/covid-19/news/?id=1055-424820</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref47">
        <label>47</label>
        <nlm-citation citation-type="web">
          <article-title>Mayor Cantrell issues stay home mandate in response to COVID-19</article-title>
          <source>Mayor's Office</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://nola.gov/mayor/news/march-2020/mayor-cantrell-issues-stay-home-mandate-in-response-to-covid-19/">http://nola.gov/mayor/news/march-2020/mayor-cantrell-issues-stay-home-mandate-in-response-to-covid-19/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref48">
        <label>48</label>
        <nlm-citation citation-type="web">
          <article-title>Inslee orders Washingtonians to stay at home to slow spread of coronavirus</article-title>
          <source>The Seattle Times</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.seattletimes.com/seattle-news/inslee-to-hold-televised-address-monday-evening-to-announce-enhanced-strategies-on-covid-19/">https://www.seattletimes.com/seattle-news/inslee-to-hold-televised-address-monday-evening-to-announce-enhanced-strategies-on-covid-19/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref49">
        <label>49</label>
        <nlm-citation citation-type="web">
          <article-title>Governor Cuomo Signs the 'New York State on PAUSE' Executive Order</article-title>
          <source>New York State</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.governor.ny.gov/news/governor-cuomo-signs-new-york-state-pause-executive-order">https://www.governor.ny.gov/news/governor-cuomo-signs-new-york-state-pause-executive-order</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref50">
        <label>50</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Pugh</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Dallas County judge announces stay-at-home order effective just before midnight March 23 for all residents</article-title>
          <source>Community Impact Newspaper</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://communityimpact.com/dallas-fort-worth/coppell-valley-ranch-las-colinas/coronavirus/2020/03/22/breaking-dallas-county-judge-announces-stay-at-home-order-effective-just-before-midnight-march-23-for-all-residents/">https://tinyurl.com/hx7hnhnp</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref51">
        <label>51</label>
        <nlm-citation citation-type="web">
          <article-title>Emergency Executive Order 20-48</article-title>
          <source>State of Minnesota</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.leg.mn.gov/archive/execorders/20-48.pdf">https://www.leg.mn.gov/archive/execorders/20-48.pdf</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref52">
        <label>52</label>
        <nlm-citation citation-type="web">
          <article-title>Amid Ongoing COVID-19 Pandemic, Governor Cuomo Issues Executive Order Requiring All People in New York to Wear Masks or Face Coverings in Public</article-title>
          <source>New York State</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.governor.ny.gov/news/amid-ongoing-covid-19-pandemic-governor-cuomo-issues-executive-order-requiring-all-people-new">https://www.governor.ny.gov/news/amid-ongoing-covid-19-pandemic-governor-cuomo-issues-executive-order-requiring-all-people-new</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref53">
        <label>53</label>
        <nlm-citation citation-type="confproc">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Selvaraju</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Cogswell</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Das</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Vedantam</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Parikh</surname>
              <given-names>D</given-names>
            </name>
            <name name-style="western">
              <surname>Batra</surname>
              <given-names>D</given-names>
            </name>
          </person-group>
          <article-title>Grad-CAM: Visual Explanations from Deep Networks via Gradient-Based Localization</article-title>
          <year>2017</year>
          <conf-name>2017 IEEE International Conference on Computer Vision (ICCV)</conf-name>
          <conf-date>October 22-29, 2017</conf-date>
          <conf-loc>Venice, Italy</conf-loc>
          <pub-id pub-id-type="doi">10.1109/iccv.2017.74</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref54">
        <label>54</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Eysenbach</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Infodemiology and infoveillance: framework for an emerging set of public health informatics methods to analyze search, communication and publication behavior on the Internet</article-title>
          <source>J Med Internet Res</source>
          <year>2009</year>
          <month>03</month>
          <day>27</day>
          <volume>11</volume>
          <issue>1</issue>
          <fpage>e11</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2009/1/e11/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/jmir.1157</pub-id>
          <pub-id pub-id-type="medline">19329408</pub-id>
          <pub-id pub-id-type="pii">v11i1e11</pub-id>
          <pub-id pub-id-type="pmcid">PMC2762766</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref55">
        <label>55</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Chu</surname>
              <given-names>HY</given-names>
            </name>
            <name name-style="western">
              <surname>Englund</surname>
              <given-names>JA</given-names>
            </name>
            <name name-style="western">
              <surname>Starita</surname>
              <given-names>LM</given-names>
            </name>
            <name name-style="western">
              <surname>Famulare</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Brandstetter</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Nickerson</surname>
              <given-names>DA</given-names>
            </name>
            <name name-style="western">
              <surname>Rieder</surname>
              <given-names>MJ</given-names>
            </name>
            <name name-style="western">
              <surname>Adler</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Lacombe</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Kim</surname>
              <given-names>AE</given-names>
            </name>
            <name name-style="western">
              <surname>Graham</surname>
              <given-names>C</given-names>
            </name>
            <name name-style="western">
              <surname>Logue</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Wolf</surname>
              <given-names>CR</given-names>
            </name>
            <name name-style="western">
              <surname>Heimonen</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>McCulloch</surname>
              <given-names>DJ</given-names>
            </name>
            <name name-style="western">
              <surname>Han</surname>
              <given-names>PD</given-names>
            </name>
            <name name-style="western">
              <surname>Sibley</surname>
              <given-names>TR</given-names>
            </name>
            <name name-style="western">
              <surname>Lee</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Ilcisin</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Fay</surname>
              <given-names>K</given-names>
            </name>
            <name name-style="western">
              <surname>Burstein</surname>
              <given-names>R</given-names>
            </name>
            <name name-style="western">
              <surname>Martin</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Lockwood</surname>
              <given-names>CM</given-names>
            </name>
            <name name-style="western">
              <surname>Thompson</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Lutz</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Jackson</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Hughes</surname>
              <given-names>JP</given-names>
            </name>
            <name name-style="western">
              <surname>Boeckh</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Shendure</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Bedford</surname>
              <given-names>T</given-names>
            </name>
            <collab>Seattle Flu Study Investigators</collab>
          </person-group>
          <article-title>Early Detection of Covid-19 through a Citywide Pandemic Surveillance Platform</article-title>
          <source>N Engl J Med</source>
          <year>2020</year>
          <month>07</month>
          <day>09</day>
          <volume>383</volume>
          <issue>2</issue>
          <fpage>185</fpage>
          <lpage>187</lpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="http://europepmc.org/abstract/MED/32356944"/>
          </comment>
          <pub-id pub-id-type="doi">10.1056/NEJMc2008646</pub-id>
          <pub-id pub-id-type="medline">32356944</pub-id>
          <pub-id pub-id-type="pmcid">PMC7206929</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref56">
        <label>56</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Sharma</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Bashir</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Use of apps in the COVID-19 response and the loss of privacy protection</article-title>
          <source>Nat Med</source>
          <year>2020</year>
          <month>08</month>
          <day>26</day>
          <volume>26</volume>
          <issue>8</issue>
          <fpage>1165</fpage>
          <lpage>1167</lpage>
          <pub-id pub-id-type="doi">10.1038/s41591-020-0928-y</pub-id>
          <pub-id pub-id-type="medline">32457443</pub-id>
          <pub-id pub-id-type="pii">10.1038/s41591-020-0928-y</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref57">
        <label>57</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Saran</surname>
              <given-names>S</given-names>
            </name>
            <name name-style="western">
              <surname>Singh</surname>
              <given-names>P</given-names>
            </name>
            <name name-style="western">
              <surname>Kumar</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Chauhan</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>Review of Geospatial Technology for Infectious Disease Surveillance: Use Case on COVID-19</article-title>
          <source>J Indian Soc Remote Sens</source>
          <year>2020</year>
          <month>08</month>
          <day>18</day>
          <volume>48</volume>
          <issue>8</issue>
          <fpage>1121</fpage>
          <lpage>1138</lpage>
          <pub-id pub-id-type="doi">10.1007/s12524-020-01140-5</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref58">
        <label>58</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Amit</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Kimhi</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Bader</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Chen</surname>
              <given-names>J</given-names>
            </name>
            <name name-style="western">
              <surname>Glassberg</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Benov</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Mass-surveillance technologies to fight coronavirus spread: the case of Israel</article-title>
          <source>Nat Med</source>
          <year>2020</year>
          <month>08</month>
          <day>26</day>
          <volume>26</volume>
          <issue>8</issue>
          <fpage>1167</fpage>
          <lpage>1169</lpage>
          <pub-id pub-id-type="doi">10.1038/s41591-020-0927-z</pub-id>
          <pub-id pub-id-type="medline">32457444</pub-id>
          <pub-id pub-id-type="pii">10.1038/s41591-020-0927-z</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref59">
        <label>59</label>
        <nlm-citation citation-type="web">
          <article-title>Coronavirus brings China's surveillance state out of the shadows</article-title>
          <source>Reuters</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.reuters.com/article/us-china-health-surveillance-idUSKBN2011HO">https://www.reuters.com/article/us-china-health-surveillance-idUSKBN2011HO</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref60">
        <label>60</label>
        <nlm-citation citation-type="web">
          <article-title>Coronavirus could be a ‘catalyst’ for China to boost its mass surveillance machine, experts say</article-title>
          <source>CNBC</source>
          <access-date>2021-04-29</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.cnbc.com/2020/02/25/coronavirus-china-to-boost-mass-surveillance-machine-experts-say.html">https://www.cnbc.com/2020/02/25/coronavirus-china-to-boost-mass-surveillance-machine-experts-say.html</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref61">
        <label>61</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Kharpal</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Use of surveillance to fight coronavirus raises concerns about government power after pandemic ends</article-title>
          <source>CNBC</source>
          <access-date>2021-04-29</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.cnbc.com/2020/03/27/coronavirus-surveillance-used-by-governments-to-fight-pandemic-privacy-concerns.html">https://www.cnbc.com/2020/03/27/coronavirus-surveillance-used-by-governments-to-fight-pandemic-privacy-concerns.html</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref62">
        <label>62</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Tenkanen</surname>
              <given-names>H</given-names>
            </name>
            <name name-style="western">
              <surname>Di Minin</surname>
              <given-names>E</given-names>
            </name>
            <name name-style="western">
              <surname>Heikinheimo</surname>
              <given-names>V</given-names>
            </name>
            <name name-style="western">
              <surname>Hausmann</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Herbst</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Kajala</surname>
              <given-names>L</given-names>
            </name>
            <name name-style="western">
              <surname>Toivonen</surname>
              <given-names>T</given-names>
            </name>
          </person-group>
          <article-title>Instagram, Flickr, or Twitter: Assessing the usability of social media data for visitor monitoring in protected areas</article-title>
          <source>Sci Rep</source>
          <year>2017</year>
          <month>12</month>
          <day>14</day>
          <volume>7</volume>
          <issue>1</issue>
          <fpage>17615</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://doi.org/10.1038/s41598-017-18007-4"/>
          </comment>
          <pub-id pub-id-type="doi">10.1038/s41598-017-18007-4</pub-id>
          <pub-id pub-id-type="medline">29242619</pub-id>
          <pub-id pub-id-type="pii">10.1038/s41598-017-18007-4</pub-id>
          <pub-id pub-id-type="pmcid">PMC5730565</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref63">
        <label>63</label>
        <nlm-citation citation-type="web">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Maloney</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>The effect of face mask mandates during the COVID-19 pandemic on the rate of mask use in the United States</article-title>
          <source>medRxiv</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.medrxiv.org/content/10.1101/2020.10.03.20206326v2">https://www.medrxiv.org/content/10.1101/2020.10.03.20206326v2</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref64">
        <label>64</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Li</surname>
              <given-names>T</given-names>
            </name>
            <name name-style="western">
              <surname>Liu</surname>
              <given-names>Y</given-names>
            </name>
            <name name-style="western">
              <surname>Li</surname>
              <given-names>M</given-names>
            </name>
            <name name-style="western">
              <surname>Qian</surname>
              <given-names>X</given-names>
            </name>
            <name name-style="western">
              <surname>Dai</surname>
              <given-names>SY</given-names>
            </name>
          </person-group>
          <article-title>Mask or no mask for COVID-19: A public health and market study</article-title>
          <source>PLoS One</source>
          <year>2020</year>
          <month>8</month>
          <day>14</day>
          <volume>15</volume>
          <issue>8</issue>
          <fpage>e0237691</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0237691"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0237691</pub-id>
          <pub-id pub-id-type="medline">32797067</pub-id>
          <pub-id pub-id-type="pii">PONE-D-20-11539</pub-id>
          <pub-id pub-id-type="pmcid">PMC7428176</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref65">
        <label>65</label>
        <nlm-citation citation-type="web">
          <article-title>Texas Stay at Home Order Expires April 30; Restaurants, Malls, Movie Theaters Can Open May 1</article-title>
          <source>Texarkana Today</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://txktoday.com/featured-2/texas-stay-at-home-order-expires-april-30/">https://txktoday.com/featured-2/texas-stay-at-home-order-expires-april-30/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref66">
        <label>66</label>
        <nlm-citation citation-type="web">
          <article-title>Malls, movies and more: A look at reopenings by state in US</article-title>
          <source>ABC News</source>
          <access-date>2021-12-25</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://abcnews.go.com/Health/wireStory/malls-movies-reopenings-state-us-70497170">https://abcnews.go.com/Health/wireStory/malls-movies-reopenings-state-us-70497170</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref67">
        <label>67</label>
        <nlm-citation citation-type="web">
          <article-title>Inslee signs new COVID-19 order for phased re-opening of Washington’s economy</article-title>
          <source>Medium</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://medium.com/wagovernor/inslee-signs-new-covid-19-order-for-phased-re-opening-of-washingtons-economy-ad5ea919ab56">https://medium.com/wagovernor/inslee-signs-new-covid-19-order-for-phased-re-opening-of-washingtons-economy-ad5ea919ab56</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref68">
        <label>68</label>
        <nlm-citation citation-type="web">
          <article-title>Gov. Edwards Signs Order Moving Louisiana to Phase One on May 15</article-title>
          <source>Office of the Governor</source>
          <access-date>2021-04-28</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://gov.louisiana.gov/news/PhaseOne">https://gov.louisiana.gov/news/PhaseOne</ext-link>
          </comment>
        </nlm-citation>
      </ref>
      <ref id="ref69">
        <label>69</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Blank</surname>
              <given-names>G</given-names>
            </name>
            <name name-style="western">
              <surname>Lutz</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Representativeness of Social Media in Great Britain: Investigating Facebook, LinkedIn, Twitter, Pinterest, Google+, and Instagram</article-title>
          <source>American Behavioral Scientist</source>
          <year>2017</year>
          <month>06</month>
          <day>29</day>
          <volume>61</volume>
          <issue>7</issue>
          <fpage>741</fpage>
          <lpage>756</lpage>
          <pub-id pub-id-type="doi">10.1177/0002764217717559</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref70">
        <label>70</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Boy</surname>
              <given-names>JD</given-names>
            </name>
            <name name-style="western">
              <surname>Uitermark</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>How to Study the City on Instagram</article-title>
          <source>PLoS One</source>
          <year>2016</year>
          <month>6</month>
          <day>23</day>
          <volume>11</volume>
          <issue>6</issue>
          <fpage>e0158161</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://dx.plos.org/10.1371/journal.pone.0158161"/>
          </comment>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0158161</pub-id>
          <pub-id pub-id-type="medline">27336728</pub-id>
          <pub-id pub-id-type="pii">PONE-D-16-04047</pub-id>
          <pub-id pub-id-type="pmcid">PMC4919013</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref71">
        <label>71</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Rovetta</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Bhagavathula</surname>
              <given-names>AS</given-names>
            </name>
          </person-group>
          <article-title>Global Infodemiology of COVID-19: Analysis of Google Web Searches and Instagram Hashtags</article-title>
          <source>J Med Internet Res</source>
          <year>2020</year>
          <month>08</month>
          <day>25</day>
          <volume>22</volume>
          <issue>8</issue>
          <fpage>e20673</fpage>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.jmir.org/2020/8/e20673/"/>
          </comment>
          <pub-id pub-id-type="doi">10.2196/20673</pub-id>
          <pub-id pub-id-type="medline">32748790</pub-id>
          <pub-id pub-id-type="pii">v22i8e20673</pub-id>
          <pub-id pub-id-type="pmcid">PMC7458585</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref72">
        <label>72</label>
        <nlm-citation citation-type="journal">
          <person-group person-group-type="author">
            <name name-style="western">
              <surname>Zhou</surname>
              <given-names>B</given-names>
            </name>
            <name name-style="western">
              <surname>Lapedriza</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Khosla</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Oliva</surname>
              <given-names>A</given-names>
            </name>
            <name name-style="western">
              <surname>Torralba</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Places: A 10 Million Image Database for Scene Recognition</article-title>
          <source>IEEE Trans. Pattern Anal. Mach. Intell</source>
          <year>2018</year>
          <month>6</month>
          <day>1</day>
          <volume>40</volume>
          <issue>6</issue>
          <fpage>1452</fpage>
          <lpage>1464</lpage>
          <pub-id pub-id-type="doi">10.1109/tpami.2017.2723009</pub-id>
        </nlm-citation>
      </ref>
      <ref id="ref73">
        <label>73</label>
        <nlm-citation citation-type="web">
          <article-title>COVID-19 Community Mobility Report</article-title>
          <source>Google</source>
          <access-date>2021-04-29</access-date>
          <comment>
            <ext-link ext-link-type="uri" xlink:type="simple" xlink:href="https://www.google.com/covid19/mobility/">https://www.google.com/covid19/mobility/</ext-link>
          </comment>
        </nlm-citation>
      </ref>
    </ref-list>
  </back>
</article>
