One of the first steps taken by the government was to develop functional emergency operations centers and to detect the route of disease spread in Pakistan. The origin of the virus was the first question; hence, detailed history-taking of patients was crucial not only in understanding the outbreak but also in determining the contacts of patients with other people in the community [15]. This helped in cordoning off areas or home-bounding people who came in close contact with a patient with COVID-19. In addition to this, patients with a recent international travel history were monitored closely. This made sense because many cases and massive spread was reported in the countries neighboring Pakistan [15-17].

Once primary and secondary contact-tracing was delineated, the foremost step taken by the government was to control the borders [18]. This was a crucial decision, owing to the consideration of a large number of Pakistani students and pilgrims studying in and travelling from China, Iran, and Europe. The government gained the confidence of the affected individuals and their families. It was almost unfeasible to restrict such individuals outside the country because of the strong public response; nonetheless, it was necessary if the spread of the virus was to be controlled quickly. To tackle this problem, the government took the initiative of designating quarantine houses near borders and airports to isolate people entering Pakistan for a short period to make sure they were not infected before they moved out in the community [19,20].

The WHO reported that the number of new cases increased by the minute, and disease spread was now not only limited to people who had a recent travel history in the regions highly affected by the pandemic. Disease spread within the community was alarming and called for drastic steps to be taken not only by local governments but also by countries and states at large. All necessary services and measures are still being used in maximum capacity till date to ensure the safety of people’s lives in the country. Since all cases initially had a history of recent travel, it was speculated that transmissions were imported from outside of the country. Therefore, travel restrictions were imposed to limit the spread of virus from other countries to Pakistan [21].

After the borders were contained, it was important for the government to provide a solution to all individuals stuck at the borders to enter the country without imposing a threat to the rest of the community [20]. It was crucial to quarantine the people at a specific location and either have them tested or wait for at least 2 weeks to ensure that they were not infected with SARS-CoV-2 before they travelled to their hometowns. People who did not show any symptoms after being quarantined for a certain duration could go to their cities and notify the authorities in case of any signs and symptoms after leaving the quarantine homes [19,20]. The development of these shelters was an economically and strategically massive task for the government. More than 3000 pilgrims arrived from Iran in the first week of March 2020 alone and were housed at quarantine shelters in Taftan and Chaman [22,23].

Toward the end of March 2020, the government decided to relocate the pilgrims to their respective provinces where quarantine centers were set up. Most news outlets and social media users condemned this step taken by the government. Many problems were faced by the pilgrims and other people who were quarantined at these centers, including included small, cramped spaces for people to live in, unhygienic conditions, shortage of food, water, medication, and unavailability of physicians [23].

Many other steps were taken by the government to tackle disease spread and to minimize the damage caused by the pandemic in Pakistan [24,25].

One of the first steps that the government of Pakistan took to limit the spread of the virus within the community was to impose well-planned lockdowns in all major cities [20,26]. Lockdowns were imposed during different hours in different regions, and most of the public spaces were closed off except for grocery stores, pharmacies, and vegetable and fruit shops. All the eateries, parks, wedding halls, schools, and offices were closed until further notice by the federal government [27]. This led to retaliation from the provincial governments and opposition as it posed a great economic threat to the country’s daily-wage workers and to the low-income population; however, this was a necessary measure to curtail disease spread. Another step that the government took, and faced major opposition, was the closure of prayers at mosques, including Friday prayers [26,28,29].

When reports of virus transmission started emerging, especially in the federal capital of Islamabad, the government took the initiative of sealing off areas that reported infections. According to a notification issued by the District Magistrate Islamabad, the city administration decided to cordon off areas to ensure public safety after the number of infections increased [30]. Samples were tested by the National Institute of Health, Islamabad, and analyzed by epidemiologists of the deputy commissioner of the COVID-19 Nerve Centre after which the notification was issued. This helped in not only curbing the spread of the infection but also in contact-tracing and further testing of the public.

The country’s testing capacity was limited during the early months of the pandemic, and while high-income countries were conducting large-scale randomized tests to estimate the actual number of confirmed cases, Pakistan was forced to carry out priority-based testing and rely on the enforcement of strict quarantine and isolation strategies to contain the pandemic [31]. Contact-tracing, however, was an effective strategy that not only helped limit the spread of the virus but also helped predict its route through different regions of the country and across different age groups. Nevertheless, since large-scale testing was crucial to assess the severity of the pandemic, the testing capacity of laboratories and the availability of testing kits was gradually increased by the government, and in June 2020 up to 30,000 tests were conducted daily to ascertain the pace of spread and to formulate future strategies accordingly [32]. Both these strategies provided valuable insights on the differences in the clinical manifestation of COVID-19 in people with different demographic and health backgrounds.

The Training Programs in Epidemiology and Public Health Interventions Network is a network of 75 field epidemiology training programs, which operate in >100 countries including Pakistan. After the WHO declared COVID-19 a public health emergency of international concern, alumni from the Field Epidemiology Training Program implemented standard operating procedures (SOPs) for COVID-19 screening at international airports in Pakistan. They also designed and implemented a real-time data entry system to screen travelers from high-risk countries [33].

SOPs were devised for the public and were meant to be strictly followed in public areas. These included guidelines on social distancing; that is, avoiding crowded areas, maintaining a physical distance of 3 feet, wearing masks, maintaining hand hygiene, sanitizing frequently touched surfaces and areas, and following general hygiene rules such as avoiding touching the face, nose, or eyes, and coughing, or sneezing in the elbow or a paper napkin instead of the hands. The authorities started taking disciplinary action against those who violated the SOPs at public places in various parts of the country in accordance with the recommendations of the National Command and Control Centre of Pakistan. The focus of the National Command and Control Centre was on SOPs, compliance, strict administrative actions being implemented, and enforcement of various strands of the track, trace, and quarantine strategy [34].

Many campaigns were initiated by both local and federal governments in the interest of the general population to spread awareness about the risks, signs, and symptoms of COVID-19 [35]. Pakistan’s extensive polio vaccination program, consisting of more than 265,000 community health workers and vaccinators, was mobilized with the help of the WHO [36]. This not only helped provide infrastructure to track and trace cases early during the epidemic but also helped spread awareness in the remote, underdeveloped rural regions of Pakistan. Another vital step was taken to spread awareness to the masses, where text messages were sent by the government of Pakistan on all mobile networks [37]. The daily reminders on following SOPs helped tackle those who did not take the necessary precautions and were unaware of the aforementioned information, and the imposition of fines and charges for noncompliance made risk and awareness campaigns a nationwide success [35,37].

Recorded voice messages in various local languages including Urdu, Pashto, and Sindhi, which warned against the risks of COVID-19, its spread, and its complications, and general awareness regarding the SOPs to help control its spread, were used as caller tunes before every phone call. The recorded messages were changed in accordance with the situation and ranged from guidelines on SOPs, warning noncompliers, and even congratulating efforts after successfully controlling disease spread during August 2020 [37].

On the emergence of COVID-19 in Pakistan, the entire system faced various problems owing to the limitations of the health care system, poor infrastructure, uneven access to health care, resistance from various social, political, cultural, and religious groups, political instability, economic fragilities, and mistrust among the public. Data of a web-based survey conducted by the Small and Medium Enterprises Development Authority from April 3-14, 2020, among 920 businesses revealed insufficient revenue generation, losses, and difficulty in survival among businesses [38]. Pakistan launched various schemes to tackle the economic crisis faced by many individuals during the pandemic. On May 2, 2020, Prime Minister Imran Khan launched a relief scheme for people who lost their jobs or whose source of income has been compromised owing to the lockdown. He launched a cash assistance program through the Ehsaas Cash Programme to support unemployed individuals [39].

After lifting the lockdown in some sectors, the government allowed construction and daily-wage workers to resume working while dutifully following the SOPs and taking necessary precautions. This helped ease some of the economic burdens of the government, especially in providing rations and relief packages for the daily-wage workers [40].

Furthermore, the government also requested people who had been diagnosed with mild or asymptomatic COVID-19 to quarantine at home as some of them did not required hospital care; this helped curb the patient influx in hospitals and at diagnostic centers, thus easing the burden on health workers and medical practitioners [41].

One of the largest concerns for the ministry of health and health departments in Pakistan and worldwide is coping with the continuously increasing demand of ventilators as the virus spreads and the number of cases increases. The shortage of ventilators is a major issue faced by Pakistan, especially because all the major medical equipment are imported and not produced locally. To tackle this problem, the National Radio and Telecommunication Corporation produced its first ventilator locally within a few months of the onset of the pandemic [42]. The National Radio and Telecommunications Corporation initially offered cost-free repairs for almost 109 ventilators throughout the country and later designed and produced its own ventilators. Initially, 8 ventilators were produced and handed over to the National Disaster Management Authority after which the prime minister formally inaugurated a facility for large-scale production of ventilators within Pakistan [43].

As a result of all the efforts made by the government of Pakistan, 6 months after reporting its first case, active cases in Pakistan are continuing to steadily decrease, with the number of deaths recorded in a day now often down to single-digit numbers. The country has had 312,263 confirmed cases of as on October 1, 2020, with 6479 COVID-19–related deaths, according to the official data [44]. Save for single-day glitches, active cases have been progressively declining since peaking in June 2020, currently standing at 8903, their lowest level since late April 2020.

Al-Khidmat Foundation Pakistan is one of the leading nonprofit foundations operating in Pakistan for the past 30 years. During the onset of the pandemic, it played a vital role in charity work including awareness campaigns, providing preventive equipment such as soap, sanitizers, masks, and relevant reading material to the general public, providing its services to government institutions including hospitals, Aghosh homes, ambulances, and trained volunteers. Moreover, it carried out food drives, provided COVID-19 test facilities and antibody tests, and arranged for protective equipment to distribute among physicians and medical staff on the frontline [46]. Al-Khidmat Foundation Pakistan also played a vital role in arranging free plasma for patients with COVID-19 [47].

The Facebook page titled “Corona Recovered Warriors” provided hope during the grim period of disease spread in Pakistan. Created by musician Zoraiz Riaz with the aim to help coordinate convalescent plasma donations for people with COVID-19 in Pakistan, this group quickly gained popularity and had 320,000 members in just 1 month, needing a team of 33 volunteers to manage the posts. People looking for plasma donors, medical supplies, oxygen cylinders, ventilators, injection drugs or other drugs, and leads on hospitals accepting new admittees posted all their queries on this group, and thousands of people came forward and offered help in all capacities to those in need [48]. The group then started organizing donation and food drives, providing personal protective equipment (PPE) to health care workers and delivering medical supplies to desperate families of patients with COVID-19 [49].

In desperate times when everyone is seeking any cure to tackle the virus, many unapproved and untested remedies were used even by health care professionals to treat individuals with COVID-19. The most popular one was the use of plasma of a recovered patient to treat patients with COVID-19. Dr Shahid Junejo, a senior superintendent at a civil hospital, tested plasma therapy on a patient in Hyderabad. According to him, the decision for the trial was taken after consultation with the vice chancellor of the Liaquat University of Medical and Health Sciences Jamshoro, Prof Bikha Ram Devrajani [50]. Passive immunization is an old procedure used in the absence of a vaccine to treat infectious diseases; hence, the treatment was administered to many patients throughout the country without any strong evidence of its ability to neutralize the virus [51]. Even though the Ministry of National Health Services declared that plasma therapy is not a cure for COVID-19 as it is still undergoing a clinical trial on a global scale, there is still a high demand of plasma donors, and as of July 2020 approximately 750 donors were connected with critical patients through the Corona Recovered Warriors Facebook page alone.

Scholars Against COVID-19 is a platform of over 3000 young scholars and researchers nationwide coming together as volunteers to assist the government and people through donations of equipment from laboratories and universities to scale up testing and experimentation related to the diagnosis and treatment of COVID-19 [52]. Their aim is to bridge the disconnect among various sectors in Pakistan, which makes executing such ideas challenging.

Student Taskforce Against COVID-19 is a group of final-year medical students from Aga Khan University Hospital who conceived the idea of creating a helpline for families and patients affected by COVID-19 who have been looking for guidelines and help [53]. The taskforce is not only managing the helpline but also assisting the Aga Khan University Hospital and the Sindh government in contact-tracing and helping the Pakistan Medical Association in identifying and providing volunteers to help at Karachi's Expo Centre isolation ward for patients with COVID-19 [54].

Over 400 medical students have come together through the Combat Corona campaign and are aiming to collect and provide PPE to health care workers. They have targeted hospitals in Karachi needing PPE and have collected hundreds of equipment for distribution through donations in all major hospitals of the city [54].

Pakistan Against COVID-19 Volunteers is a group of physicians and other professionals who have collaborated and aim to enable connections between manufacturers and suppliers of PPE, carry out innovation and experimentation for designing and manufacturing ventilators through 3D printing technology, and develop noncontact thermometers locally [55,56].

Kwickdoctor.com has been developed by 40-year-old information technology expert Salman Khan. He aims to connect the public to consultants, physicians, pharmacies, and laboratories and even delivers prescriptions at the doorstep. With the pandemic spreading, the need to avoid contact has increased and digital care is the need of the hour [57].

COVID-19, after being first reported in December 2019, is still swiftly spreading worldwide. Within 10 months, the mortality and morbidity rates have approached unexpected levels. Scientists, researchers, and clinicians have worked together with engineers to develop treatments, diagnostic kits, and vaccines to prevent this infection from spreading further; however, a third wave of COVID-19 is currently underway worldwide with numerous mutant strains. These mutations have rendered this virus either more virulent or resistant to previously used medications [58]. The second wave has been feared as the situation was reverting to normalcy and businesses, offices, and schools were reopening in late September or early October of 2020. The government of Pakistan started tackling COVID-19 on the basis of the experience of other countries as the disease approached Pakistan after having affected many other countries. Starting from preparing special wards, using all resources including polio and dengue teams and wards, respectively, preparing appropriate SOPs, conveying awareness messages to everyone through the television or mobile phones, updating everyone through special mobile apps and websites, showing hotspots, sharing the economic burden with the weak, and ending with smart lockdowns were some of the most impressive measures to handle the pandemic. The people of Pakistan also supported the government during this time, which is one of the most prominent reasons Pakistan overcame the first 2 waves with minimal morbidities compared to other countries.

Immunization and treatment of COVID-19 may still be questionable, but precautions and SOPs have undoubtedly been set by many. Technology has played its part in spreading awareness, but Pakistan is currently undergoing a third wave of infections. However, if precautions are taken and all SOPs are followed, the entire community can be rescued and the risk of reinfection and further waves would decline immediately. This is a situation where everyone has a responsibility toward the community and must take steps to minimize the risk of further disease spread. Pakistan has shown tremendous potential in public health, and different government and nongovernment organizations can collaborate to address the challenges through the engagement of society and the community along with the introduction of new policies.